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Chemical Superantigens

Name Superantigens
Definition Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.
Top Interacting
Genes
MeSH® ID D018089
External Links

Top ↑ Ancestors

ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Antigens Has associated genes Has associated diseases Has associated exposure references Superantigens Has associated genes Has associated diseases

Top ↑ Descendants

Superantigens Has associated genes Has associated diseases
  enterotoxin F, Staphylococcal Has associated genes Has associated diseases
  enterotoxin G, staphylococcal
  enterotoxin I, staphylococcal
  GR protein, mouse mammary tumor virus
  IDDMK1,2 22 superantigen, human
  Minor Lymphocyte Stimulatory Antigens
  Mycoplasma arthritidis mitogen Has associated genes Has associated diseases
  PfiT protein, Pseudomonas fluorescens
  SEIP protein, Staphylococcus aureus
  SEQ protein, Staphylococcus aureus
  SpeJ protein, Streptococcus pyogenes
  speL protein, Streptococcus pyogenes
  SpeM protein, Streptococcus pyogenes
  toxic shock syndrome toxin 2, Staphylococcus aureus