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Chemical GABA Modulators

Name GABA Modulators
Equivalent Terms Acid Modulators, gamma-Aminobutyric | GABAergic Modulators | gamma Aminobutyric Acid Modulators | gamma-Aminobutyric Acid Modulators | Modulators, GABA | Modulators, GABAergic | Modulators, gamma-Aminobutyric Acid
Definition Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. GABA-A receptors (RECEPTORS, GABA-A) appear to have at least three allosteric sites at which modulators act: a site at which BENZODIAZEPINES act by increasing the opening frequency of GAMMA-AMINOBUTYRIC ACID-activated chloride channels; a site at which BARBITURATES act to prolong the duration of channel opening; and a site at which some steroids may act. GENERAL ANESTHETICS probably act at least partly by potentiating GABAergic responses, but they are not included here.
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Genes
MeSH® ID D018757
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1. ChemicalsChemical Actions and Uses Has associated genes Has associated diseases Has associated exposure references Pharmacologic Actions Has associated genes Has associated diseases Has associated exposure references Molecular Mechanisms of Pharmacological Action Has associated genes Has associated diseases Has associated exposure references Neurotransmitter Agents Has associated genes Has associated diseases Has associated exposure references GABA Agents Has associated genes Has associated diseases GABA Modulators Has associated genes Has associated diseases
2. ChemicalsChemical Actions and Uses Has associated genes Has associated diseases Has associated exposure references Pharmacologic Actions Has associated genes Has associated diseases Has associated exposure references Physiological Effects of Drugs Has associated genes Has associated diseases Has associated exposure references Neurotransmitter Agents Has associated genes Has associated diseases Has associated exposure references GABA Agents Has associated genes Has associated diseases GABA Modulators Has associated genes Has associated diseases

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