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Chemical Antineoplastic Agents, Alkylating

Name Antineoplastic Agents, Alkylating
Equivalent Terms Alkylating Agents, Antineoplastic | Alkylating Antineoplastic Agents | Alkylating Antineoplastic Drugs | Alkylating Antineoplastics | Alkylating Drugs, Antineoplastic | Antineoplastic Alkylating Agents | Antineoplastic Alkylating Drugs | Antineoplastic Drugs, Alkylating | Antineoplastics, Alkylating | Drugs, Antineoplastic Alkylating
Definition A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
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Genes
MeSH® ID D018906
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1. ChemicalsChemical Actions and Uses Has associated genes Has associated diseases Has associated exposure references Pharmacologic Actions Has associated genes Has associated diseases Has associated exposure references Molecular Mechanisms of Pharmacological Action Has associated genes Has associated diseases Has associated exposure references Alkylating Agents Has associated genes Has associated diseases Antineoplastic Agents, Alkylating Has associated genes Has associated diseases
2. ChemicalsChemical Actions and Uses Has associated genes Has associated diseases Has associated exposure references Pharmacologic Actions Has associated genes Has associated diseases Has associated exposure references Therapeutic Uses Has associated genes Has associated diseases Has associated exposure references Antineoplastic Agents Has associated genes Has associated diseases Antineoplastic Agents, Alkylating Has associated genes Has associated diseases
3. ChemicalsChemical Actions and Uses Has associated genes Has associated diseases Has associated exposure references Toxic Actions Has associated genes Has associated diseases Has associated exposure references Noxae Has associated genes Has associated diseases Has associated exposure references Alkylating Agents Has associated genes Has associated diseases Antineoplastic Agents, Alkylating Has associated genes Has associated diseases

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