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Chemical Bridged Bicyclo Compounds, Heterocyclic

1–50 of 557 results.
  Chemical Phenotype Co-Mentioned Terms Interaction Organisms Anatomy Inference Network References
1. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane autophagy Sodium Selenite [Sodium Selenite co-treated with (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] results in increased autophagy 1: Homo sapiens A549 Cells
2 genes: MAP1LC3B | SQSTM1
1
2. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane apoptotic process Sodium Selenite Sodium Selenite promotes the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in increased apoptotic process] 1: Homo sapiens A549 Cells
5 genes: BAX | BCL2 | CASP3 | CDK1 | SQSTM1
1
3. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in decreased cell proliferation 1: Homo sapiens Lung | Cell Line, Tumor
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
4. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane mitotic cell cycle arrest Sodium Selenite Sodium Selenite promotes the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in increased mitotic cell cycle arrest] 1: Homo sapiens A549 Cells 1 gene: CDKN1A 1
5. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation Sodium Selenite (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane promotes the reaction [Sodium Selenite results in decreased cell proliferation] 1: Homo sapiens A549 Cells
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
6. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation Sodium Selenite | TXNRD1 Sodium Selenite promotes the reaction [[TXNRD1 protein results in increased susceptibility to (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] which results in decreased cell proliferation] 1: Homo sapiens HEK293 Cells
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
7. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane necrotic cell death Sodium Selenite Sodium Selenite promotes the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in increased necrotic cell death] 1: Homo sapiens A549 Cells   1
8. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane apoptotic process (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in increased apoptotic process 1: Homo sapiens A549 Cells
5 genes: BAX | BCL2 | CASP3 | CDK1 | SQSTM1
1
9. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in decreased cell proliferation 1: Homo sapiens A549 Cells
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
10. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell death Sodium Selenite [Sodium Selenite results in increased susceptibility to (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] which results in increased cell death 1: Homo sapiens A549 Cells   1
11. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation Sodium Selenite Sodium Selenite promotes the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in decreased cell proliferation] 1: Homo sapiens Lung | Cell Line, Tumor
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
12. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation Sodium Selenite Sodium Selenite promotes the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in decreased cell proliferation] 1: Homo sapiens A549 Cells
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
13. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation TXNRD1 [TXNRD1 protein results in increased susceptibility to (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane] which results in decreased cell proliferation 1: Homo sapiens HEK293 Cells
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
14. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane mitotic cell cycle arrest (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in increased mitotic cell cycle arrest 1: Homo sapiens A549 Cells 1 gene: CDKN1A 1
15. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane necrotic cell death (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in increased necrotic cell death 1: Homo sapiens A549 Cells   1
16. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation Sodium Selenite (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane promotes the reaction [Sodium Selenite results in decreased cell proliferation] 1: Homo sapiens Lung | Cell Line, Tumor
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
17. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation Chloroquine | Sodium Selenite Chloroquine inhibits the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane promotes the reaction [Sodium Selenite results in decreased cell proliferation]] 1: Homo sapiens A549 Cells
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
18. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation Chloroquine | Sodium Selenite Chloroquine inhibits the reaction [Sodium Selenite promotes the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in decreased cell proliferation]] 1: Homo sapiens A549 Cells
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
19. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation 3-methyladenine | Sodium Selenite 3-methyladenine inhibits the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane promotes the reaction [Sodium Selenite results in decreased cell proliferation]] 1: Homo sapiens A549 Cells
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
20. (1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane cell proliferation 3-methyladenine | Sodium Selenite 3-methyladenine inhibits the reaction [Sodium Selenite promotes the reaction [(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane results in decreased cell proliferation]] 1: Homo sapiens A549 Cells
6 genes: BAX | BCL2 | CDK1 | CDK4 | TXN | TXNRD1
1
21. 1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo(3,4-b)pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea monocyte chemotaxis CCL2 1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo(3,4-b)pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea inhibits the reaction [CCL2 protein results in increased monocyte chemotaxis] 1: Homo sapiens Monocytes | Cell Line, Tumor   1
22. 1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo(3,4-b)pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea chemotaxis CCL4 1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo(3,4-b)pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea affects the reaction [CCL4 protein results in increased chemotaxis] 1: Homo sapiens Blood | Leukocytes, Mononuclear   1
23. 2-(6-((3,4-dihydro-2H-chromen-2-ylmethyl)amino)hexyl)tetrahydro-1H-pyrrolo(1,2-c)imidazole-1,3(2H)-dione cell death Glucose | Oxygen 2-(6-((3,4-dihydro-2H-chromen-2-ylmethyl)amino)hexyl)tetrahydro-1H-pyrrolo(1,2-c)imidazole-1,3(2H)-dione inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased cell death] 1: Rattus norvegicus Hippocampus | Cells, Cultured   1
24. 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide lipid oxidation 4-hydroxy-2-nonenal | Diethylnitrosamine 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide inhibits the reaction [[Diethylnitrosamine results in increased lipid oxidation] which results in increased abundance of 4-hydroxy-2-nonenal] 1: Mus musculus Liver   1
25. 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide positive regulation of neutrophil chemotaxis Diethylnitrosamine 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide inhibits the reaction [Diethylnitrosamine results in increased positive regulation of neutrophil chemotaxis] 1: Mus musculus Liver
2 genes: IL1B | IL23A
1
26. 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide positive regulation of apoptotic process Diethylnitrosamine 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide promotes the reaction [Diethylnitrosamine results in increased positive regulation of apoptotic process] 1: Mus musculus Liver
3 genes: IFNG | IL1B | TNF
1
27. 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide positive regulation of monocyte chemotaxis Diethylnitrosamine 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide inhibits the reaction [Diethylnitrosamine results in increased positive regulation of monocyte chemotaxis] 1: Mus musculus Liver   1
28. 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide lipid oxidation Diethylnitrosamine | Malondialdehyde 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide inhibits the reaction [[Diethylnitrosamine results in increased lipid oxidation] which results in increased abundance of Malondialdehyde] 1: Mus musculus Liver   1
29. 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide lipid oxidation Diethylnitrosamine 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide inhibits the reaction [Diethylnitrosamine results in increased lipid oxidation] 1: Mus musculus Liver   1
30. 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide positive regulation of cell proliferation 2-fluoro-N-methyl-4-(7-(quinolin-6-yl-methyl)imidazo(1,2-b)(1,2,4)triazin-2-yl)benzamide results in increased positive regulation of cell proliferation 1: Mus musculus Liver
3 genes: IFNG | IL1B | TNF
1
31. 3-(3-bromothiophen-2-yl)-8-methyl-8-azabicyclo(3.2.1)oct-2-ene intestinal motility Morphine 3-(3-bromothiophen-2-yl)-8-methyl-8-azabicyclo(3.2.1)oct-2-ene inhibits the reaction [Morphine results in decreased intestinal motility] 1: Mus musculus Feces   1
32. 3-(3-bromothiophen-2-yl)-8-methyl-8-azabicyclo(3.2.1)oct-2-ene intestinal motility 3-(3-bromothiophen-2-yl)-8-methyl-8-azabicyclo(3.2.1)oct-2-ene results in decreased intestinal motility 1: Mus musculus Feces   1
33. 3,4-dehydrobrevicomin obsolete positive regulation of cAMP catabolic process 3,4-dehydrobrevicomin results in increased obsolete positive regulation of cAMP catabolic process 1: Mus musculus Vomeronasal Organ   1
34. 3,4-dehydrobrevicomin obsolete positive regulation of cAMP biosynthetic process 3,4-dehydrobrevicomin results in increased obsolete positive regulation of cAMP biosynthetic process 1: Mus musculus Olfactory Receptor Neurons   1
35. 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid positive regulation of protein import into nucleus HIF1A [4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid results in decreased positive regulation of protein import into nucleus] which affects the localization of HIF1A protein 1: Homo sapiens Pancreas | Cell Line, Tumor   1
36. 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid activation of protein kinase B activity AM 251 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid inhibits the reaction [AM 251 results in increased activation of protein kinase B activity] 1: Homo sapiens Pancreas | Cell Line, Tumor   1
37. 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid positive regulation of protein import into nucleus PKM [4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid results in decreased positive regulation of protein import into nucleus] which affects the localization of PKM protein modified form 1: Homo sapiens Pancreas | Cell Line, Tumor   1
38. 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid positive regulation of protein import into nucleus CTNNB1 [4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid results in decreased positive regulation of protein import into nucleus] which affects the localization of CTNNB1 protein modified form 1: Homo sapiens Pancreas | Cell Line, Tumor   1
39. 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid positive regulation of protein import into nucleus AM 251 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid inhibits the reaction [AM 251 results in increased positive regulation of protein import into nucleus] 1: Homo sapiens Pancreas | Cell Line, Tumor   1
40. 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid positive regulation of protein import into nucleus ABCB1 [4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid results in decreased positive regulation of protein import into nucleus] which affects the localization of ABCB1 protein 1: Homo sapiens Pancreas | Cell Line, Tumor   1
41. 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid positive regulation of protein import into nucleus AM 251 | PKM 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid inhibits the reaction [[AM 251 results in increased positive regulation of protein import into nucleus] which affects the localization of PKM protein modified form] 1: Homo sapiens Pancreas | Cell Line, Tumor   1
42. 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid positive regulation of protein import into nucleus AM 251 | CTNNB1 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid inhibits the reaction [[AM 251 results in increased positive regulation of protein import into nucleus] which affects the localization of CTNNB1 protein modified form] 1: Homo sapiens Pancreas | Cell Line, Tumor   1
43. 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid activation of protein kinase B activity 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid results in decreased activation of protein kinase B activity 1: Homo sapiens Pancreas | Cell Line, Tumor   1
44. 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid positive regulation of protein import into nucleus ABCG2 [4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid results in decreased positive regulation of protein import into nucleus] which affects the localization of ABCG2 protein 1: Homo sapiens Pancreas | Cell Line, Tumor   1
45. 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid positive regulation of protein import into nucleus AM 251 | HIF1A 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid inhibits the reaction [[AM 251 results in increased positive regulation of protein import into nucleus] which affects the localization of HIF1A protein] 1: Homo sapiens Pancreas | Cell Line, Tumor   1
46. 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid positive regulation of protein import into nucleus 4-(4-(3-hydroxyphenyl)-3-(4-methylphenyl)-6-oxo-1H,4H,5H,6H-pyrrolo(3,4-c)pyrazol-5-yl)benzoic acid results in decreased positive regulation of protein import into nucleus 1: Homo sapiens Pancreas | Cell Line, Tumor   1
47. 6-diphenylmethyl-5-(5-isopropyl-2-methoxybenzylamino)-1-azabicyclo(2.2.2)octane-3-carboxylic acid fibroblast migration Trinitrobenzenesulfonic Acid 6-diphenylmethyl-5-(5-isopropyl-2-methoxybenzylamino)-1-azabicyclo(2.2.2)octane-3-carboxylic acid inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased fibroblast migration] 1: Mus musculus Colon   1
48. 6-diphenylmethyl-5-(5-isopropyl-2-methoxybenzylamino)-1-azabicyclo(2.2.2)octane-3-carboxylic acid collagen fibril organization Trinitrobenzenesulfonic Acid 6-diphenylmethyl-5-(5-isopropyl-2-methoxybenzylamino)-1-azabicyclo(2.2.2)octane-3-carboxylic acid inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased collagen fibril organization] 1: Mus musculus Colon 1 gene: COL1A2 1
49. 6-diphenylmethyl-5-(5-isopropyl-2-methoxybenzylamino)-1-azabicyclo(2.2.2)octane-3-carboxylic acid fibroblast migration TACR1 | Trinitrobenzenesulfonic Acid 6-diphenylmethyl-5-(5-isopropyl-2-methoxybenzylamino)-1-azabicyclo(2.2.2)octane-3-carboxylic acid affects the reaction [TACR1 gene mutant form inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased fibroblast migration]] 1: Mus musculus Colon   1
50. 6-diphenylmethyl-5-(5-isopropyl-2-methoxybenzylamino)-1-azabicyclo(2.2.2)octane-3-carboxylic acid collagen fibril organization TACR1 | Trinitrobenzenesulfonic Acid 6-diphenylmethyl-5-(5-isopropyl-2-methoxybenzylamino)-1-azabicyclo(2.2.2)octane-3-carboxylic acid affects the reaction [TACR1 gene mutant form inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased collagen fibril organization]] 1: Mus musculus Colon 1 gene: COL1A2 1
1–50 of 557 results.