Okadaic Acid - Phenotypes

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	Chemical	Phenotype	Co-Mentioned Terms	Interaction	Organisms	Anatomy	Inference Network	References
1.	Okadaic Acid	positive regulation of apoptotic process		Okadaic Acid affects positive regulation of apoptotic process	1: Mus musculus	Brain \| Neurons \| Cells, Cultured	46 genes: ABL1 \| AKT1 \| ALDH1A1 \| ANXA5 \| ARHGEF17 \| BAX \| BBC3 \| BCL2L11 \| CASP3 \| CASP8 \| CASP9 \| CLU \| CREB1 \| CTNNB1 \| CYP1B1 \| DDIT3 \| DNM1L \| EGLN1 \| FOSL1 \| FOXO3 \| GRIN1 \| GSK3B \| HIF1A \| HTRA2 \| IL1B \| JAK2 \| JUN \| MAP3K10 \| MAPK8 \| MLLT11 \| MMP2 \| NGF \| PDIA3 \| PLA2G4A \| PPP2CA \| PTGS2 \| PTN \| RELA \| RXRA \| SOD1 \| TNF \| TNFSF10 \| TOP2A \| TP53 \| TRP53 \| UBC	1
2.	Okadaic Acid	calcium import into the mitochondrion		Okadaic Acid affects calcium import into the mitochondrion	1: Rattus norvegicus	Brain \| Endothelial Cells \| Cell Line	1 gene: OPA1	1
3.	Okadaic Acid	apoptotic process		Okadaic Acid results in increased apoptotic process	1: Chlorocebus aethiops	COS Cells	53 genes: ABL1 \| AKT1 \| APP \| BAX \| BBC3 \| BCL2 \| BCL2L11 \| BCL2L14 \| CASP10 \| CASP3 \| CASP7 \| CASP8 \| CASP9 \| CDK1 \| DAB2 \| DDIT3 \| EGLN3 \| EP300 \| ERN1 \| FIS1 \| FOXO3 \| GAPDH \| GJA1 \| HTRA2 \| IER3 \| IL1B \| ITPR1 \| JAK2 \| MAP3K10 \| MAPK1 \| MAPK3 \| MAPT \| MFN2 \| NFKB1 \| NFKBIA \| NR3C1 \| OPA1 \| PARP1 \| PPP2CA \| PPP2R1A \| PRDX5 \| RAD21 \| RAF1 \| RB1 \| RPS6KB1 \| TAX1BP1 \| TF \| TNF \| TNFSF10 \| TP53 \| TRP53 \| UBE2D3 \| XBP1	1
4.	Okadaic Acid	calcium-mediated signaling	Ouabain	Okadaic Acid inhibits the reaction [Ouabain results in increased calcium-mediated signaling]	1: Rattus norvegicus	Mast Cells \| Cells, Cultured	4 genes: CALM1 \| CALM2 \| GRIN1 \| TNF	1
5.	Okadaic Acid	positive regulation of cell death	NADP	NADP inhibits the reaction [Okadaic Acid results in increased positive regulation of cell death]	1: Homo sapiens	Hep G2 Cells	10 genes: ACOX2 \| BCL2L11 \| EGR1 \| EP300 \| GRIN1 \| HTRA2 \| IL1B \| PDX1 \| PTGS2 \| UCP2	1
6.	Okadaic Acid	positive regulation of apoptotic process	BBC3	BBC3 protein affects the reaction [Okadaic Acid affects positive regulation of apoptotic process]	1: Mus musculus	Brain \| Neurons \| Cells, Cultured	46 genes: ABL1 \| AKT1 \| ALDH1A1 \| ANXA5 \| ARHGEF17 \| BAX \| BBC3 \| BCL2L11 \| CASP3 \| CASP8 \| CASP9 \| CLU \| CREB1 \| CTNNB1 \| CYP1B1 \| DDIT3 \| DNM1L \| EGLN1 \| FOSL1 \| FOXO3 \| GRIN1 \| GSK3B \| HIF1A \| HTRA2 \| IL1B \| JAK2 \| JUN \| MAP3K10 \| MAPK8 \| MLLT11 \| MMP2 \| NGF \| PDIA3 \| PLA2G4A \| PPP2CA \| PTGS2 \| PTN \| RELA \| RXRA \| SOD1 \| TNF \| TNFSF10 \| TOP2A \| TP53 \| TRP53 \| UBC	1
7.	Okadaic Acid	apoptotic DNA fragmentation		Okadaic Acid results in increased apoptotic DNA fragmentation	1: Rattus norvegicus	Myocytes, Cardiac \| Cells, Cultured	1 gene: CASP3	1
8.	Okadaic Acid	apoptotic process	Benzo(a)pyrene \| Estradiol	Okadaic Acid inhibits the reaction [Estradiol inhibits the reaction [Benzo(a)pyrene results in increased apoptotic process]]	1: Homo sapiens	Hep G2 Cells	53 genes: ABL1 \| AKT1 \| APP \| BAX \| BBC3 \| BCL2 \| BCL2L11 \| BCL2L14 \| CASP10 \| CASP3 \| CASP7 \| CASP8 \| CASP9 \| CDK1 \| DAB2 \| DDIT3 \| EGLN3 \| EP300 \| ERN1 \| FIS1 \| FOXO3 \| GAPDH \| GJA1 \| HTRA2 \| IER3 \| IL1B \| ITPR1 \| JAK2 \| MAP3K10 \| MAPK1 \| MAPK3 \| MAPT \| MFN2 \| NFKB1 \| NFKBIA \| NR3C1 \| OPA1 \| PARP1 \| PPP2CA \| PPP2R1A \| PRDX5 \| RAD21 \| RAF1 \| RB1 \| RPS6KB1 \| TAX1BP1 \| TF \| TNF \| TNFSF10 \| TP53 \| TRP53 \| UBE2D3 \| XBP1	1
9.	Okadaic Acid	apoptotic process		Okadaic Acid results in increased apoptotic process	1: Rattus norvegicus	Hepatocytes \| Cells, Cultured	53 genes: ABL1 \| AKT1 \| APP \| BAX \| BBC3 \| BCL2 \| BCL2L11 \| BCL2L14 \| CASP10 \| CASP3 \| CASP7 \| CASP8 \| CASP9 \| CDK1 \| DAB2 \| DDIT3 \| EGLN3 \| EP300 \| ERN1 \| FIS1 \| FOXO3 \| GAPDH \| GJA1 \| HTRA2 \| IER3 \| IL1B \| ITPR1 \| JAK2 \| MAP3K10 \| MAPK1 \| MAPK3 \| MAPT \| MFN2 \| NFKB1 \| NFKBIA \| NR3C1 \| OPA1 \| PARP1 \| PPP2CA \| PPP2R1A \| PRDX5 \| RAD21 \| RAF1 \| RB1 \| RPS6KB1 \| TAX1BP1 \| TF \| TNF \| TNFSF10 \| TP53 \| TRP53 \| UBE2D3 \| XBP1	1
10.	Okadaic Acid	positive regulation of ion transmembrane transporter activity		Okadaic Acid results in increased positive regulation of ion transmembrane transporter activity	1: Anas platyrhynchos	Erythrocytes		1
11.	Okadaic Acid	alpha-tubulin acetylation		Okadaic Acid results in decreased alpha-tubulin acetylation	1: Rattus norvegicus	Brain \| Endothelial Cells \| Cell Line		1
12.	Okadaic Acid	regulation of mitochondrial membrane potential		Okadaic Acid results in decreased regulation of mitochondrial membrane potential	1: Rattus norvegicus	Hepatocytes \| Cells, Cultured	5 genes: BAX \| BCL2 \| SOD1 \| SOD2 \| UCP2	1
13.	Okadaic Acid	reactive oxygen species biosynthetic process	Quercetin	Quercetin inhibits the reaction [Okadaic Acid results in increased reactive oxygen species biosynthetic process]	1: Mus musculus	Hippocampus \| Cell Line		1
14.	Okadaic Acid	positive regulation of ion transmembrane transporter activity	Norepinephrine \| Rubidium	Okadaic Acid promotes the reaction [[Norepinephrine results in increased positive regulation of ion transmembrane transporter activity] which results in increased uptake of Rubidium]	1: Anas platyrhynchos	Erythrocytes		1
15.	Okadaic Acid	lipid catabolic process	Quercetin	Quercetin inhibits the reaction [Okadaic Acid results in increased lipid catabolic process]	1: Mus musculus	Hippocampus \| Cell Line	4 genes: CES1D \| LPL \| PLA2G4A \| PRDX6	1
16.	Okadaic Acid	apoptotic DNA fragmentation	Ursodeoxycholic Acid	Ursodeoxycholic Acid inhibits the reaction [Okadaic Acid results in increased apoptotic DNA fragmentation]	1: Rattus norvegicus	Hepatocytes \| Cells, Cultured	1 gene: CASP3	1
17.	Okadaic Acid	filopodium assembly	PPP1R9A	Okadaic Acid inhibits the reaction [PPP1R9A protein modified form results in increased filopodium assembly]	1: Rattus norvegicus	HEK293 Cells		1
18.	Okadaic Acid	apoptotic process	Benzo(a)pyrene \| Tetrachlorodibenzodioxin	Okadaic Acid inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Benzo(a)pyrene results in increased apoptotic process]]	1: Homo sapiens	Hep G2 Cells	53 genes: ABL1 \| AKT1 \| APP \| BAX \| BBC3 \| BCL2 \| BCL2L11 \| BCL2L14 \| CASP10 \| CASP3 \| CASP7 \| CASP8 \| CASP9 \| CDK1 \| DAB2 \| DDIT3 \| EGLN3 \| EP300 \| ERN1 \| FIS1 \| FOXO3 \| GAPDH \| GJA1 \| HTRA2 \| IER3 \| IL1B \| ITPR1 \| JAK2 \| MAP3K10 \| MAPK1 \| MAPK3 \| MAPT \| MFN2 \| NFKB1 \| NFKBIA \| NR3C1 \| OPA1 \| PARP1 \| PPP2CA \| PPP2R1A \| PRDX5 \| RAD21 \| RAF1 \| RB1 \| RPS6KB1 \| TAX1BP1 \| TF \| TNF \| TNFSF10 \| TP53 \| TRP53 \| UBE2D3 \| XBP1	1
19.	Okadaic Acid	apoptotic process	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide	N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Okadaic Acid results in increased apoptotic process]	1: Rattus norvegicus	Myocytes, Cardiac \| Cells, Cultured	53 genes: ABL1 \| AKT1 \| APP \| BAX \| BBC3 \| BCL2 \| BCL2L11 \| BCL2L14 \| CASP10 \| CASP3 \| CASP7 \| CASP8 \| CASP9 \| CDK1 \| DAB2 \| DDIT3 \| EGLN3 \| EP300 \| ERN1 \| FIS1 \| FOXO3 \| GAPDH \| GJA1 \| HTRA2 \| IER3 \| IL1B \| ITPR1 \| JAK2 \| MAP3K10 \| MAPK1 \| MAPK3 \| MAPT \| MFN2 \| NFKB1 \| NFKBIA \| NR3C1 \| OPA1 \| PARP1 \| PPP2CA \| PPP2R1A \| PRDX5 \| RAD21 \| RAF1 \| RB1 \| RPS6KB1 \| TAX1BP1 \| TF \| TNF \| TNFSF10 \| TP53 \| TRP53 \| UBE2D3 \| XBP1	1
20.	Okadaic Acid	cell death		Okadaic Acid results in increased cell death	1: Rattus norvegicus	Brain \| Endothelial Cells \| Cell Line	1 gene: MAP3K10	1
21.	Okadaic Acid	positive regulation of cell death		Okadaic Acid results in increased positive regulation of cell death	1: Homo sapiens	MCF-7 Cells	10 genes: ACOX2 \| BCL2L11 \| EGR1 \| EP300 \| GRIN1 \| HTRA2 \| IL1B \| PDX1 \| PTGS2 \| UCP2	1
22.	Okadaic Acid	apoptotic process	Norepinephrine \| Propranolol	[Propranolol co-treated with Norepinephrine] inhibits the reaction [Okadaic Acid results in increased apoptotic process]	1: Rattus norvegicus	Myocytes, Cardiac \| Cells, Cultured	53 genes: ABL1 \| AKT1 \| APP \| BAX \| BBC3 \| BCL2 \| BCL2L11 \| BCL2L14 \| CASP10 \| CASP3 \| CASP7 \| CASP8 \| CASP9 \| CDK1 \| DAB2 \| DDIT3 \| EGLN3 \| EP300 \| ERN1 \| FIS1 \| FOXO3 \| GAPDH \| GJA1 \| HTRA2 \| IER3 \| IL1B \| ITPR1 \| JAK2 \| MAP3K10 \| MAPK1 \| MAPK3 \| MAPT \| MFN2 \| NFKB1 \| NFKBIA \| NR3C1 \| OPA1 \| PARP1 \| PPP2CA \| PPP2R1A \| PRDX5 \| RAD21 \| RAF1 \| RB1 \| RPS6KB1 \| TAX1BP1 \| TF \| TNF \| TNFSF10 \| TP53 \| TRP53 \| UBE2D3 \| XBP1	1
23.	Okadaic Acid	positive regulation of apoptotic process	TRP53	TRP53 protein affects the reaction [Okadaic Acid affects positive regulation of apoptotic process]	1: Mus musculus	Brain \| Neurons \| Cells, Cultured	46 genes: ABL1 \| AKT1 \| ALDH1A1 \| ANXA5 \| ARHGEF17 \| BAX \| BBC3 \| BCL2L11 \| CASP3 \| CASP8 \| CASP9 \| CLU \| CREB1 \| CTNNB1 \| CYP1B1 \| DDIT3 \| DNM1L \| EGLN1 \| FOSL1 \| FOXO3 \| GRIN1 \| GSK3B \| HIF1A \| HTRA2 \| IL1B \| JAK2 \| JUN \| MAP3K10 \| MAPK8 \| MLLT11 \| MMP2 \| NGF \| PDIA3 \| PLA2G4A \| PPP2CA \| PTGS2 \| PTN \| RELA \| RXRA \| SOD1 \| TNF \| TNFSF10 \| TOP2A \| TP53 \| TRP53 \| UBC	1
24.	Okadaic Acid	cell proliferation	Clofibrate	Okadaic Acid inhibits the reaction [Clofibrate results in decreased cell proliferation]	1: Rattus norvegicus	Hepatocytes \| Cell Line, Tumor	21 genes: ADRA1B \| AKT1 \| BAX \| BCL2 \| CDK1 \| CREBBP \| CTNNB1 \| DAB2 \| DLG1 \| ELN \| GSK3B \| IGF1 \| MAPRE2 \| PCNA \| RAF1 \| SDCBP2 \| TNF \| TOP2A \| TP53 \| TXN \| VEGFA	1
25.	Okadaic Acid	positive regulation of ion transmembrane transporter activity	staurosporine aglycone	staurosporine aglycone inhibits the reaction [Okadaic Acid results in increased positive regulation of ion transmembrane transporter activity]	1: Anas platyrhynchos	Erythrocytes		1
26.	Okadaic Acid	response to oxidative stress		Okadaic Acid inhibits the reaction [Okadaic Acid results in increased response to oxidative stress]	1: Homo sapiens	Bone and Bones \| Cell Line, Tumor	21 genes: ABL1 \| AKT1 \| ALDH1A1 \| APP \| BCL2 \| COX2 \| DDIT3 \| EPAS1 \| JAK2 \| MMP2 \| NFKB1 \| PCNA \| PRDX5 \| PRDX6 \| PTGS2 \| SELENOP \| SOD1 \| SOD2 \| TOR1A \| TP53 \| TRP53	1
27.	Okadaic Acid	apoptotic process	BCL2	[Okadaic Acid results in increased apoptotic process] which results in increased phosphorylation of BCL2 protein		Lymphocytes \| Cell Line	53 genes: ABL1 \| AKT1 \| APP \| BAX \| BBC3 \| BCL2 \| BCL2L11 \| BCL2L14 \| CASP10 \| CASP3 \| CASP7 \| CASP8 \| CASP9 \| CDK1 \| DAB2 \| DDIT3 \| EGLN3 \| EP300 \| ERN1 \| FIS1 \| FOXO3 \| GAPDH \| GJA1 \| HTRA2 \| IER3 \| IL1B \| ITPR1 \| JAK2 \| MAP3K10 \| MAPK1 \| MAPK3 \| MAPT \| MFN2 \| NFKB1 \| NFKBIA \| NR3C1 \| OPA1 \| PARP1 \| PPP2CA \| PPP2R1A \| PRDX5 \| RAD21 \| RAF1 \| RB1 \| RPS6KB1 \| TAX1BP1 \| TF \| TNF \| TNFSF10 \| TP53 \| TRP53 \| UBE2D3 \| XBP1	1
28.	Okadaic Acid	protein serine/threonine phosphatase activity	SLCO1B1	[SLCO1B1 protein results in increased susceptibility to Okadaic Acid] which results in decreased protein serine/threonine phosphatase activity	1: Homo sapiens	HEK293 Cells	5 genes: PPP1CA \| PPP2CA \| PPP2R1A \| PPP4C \| PPP5C	1
29.	Okadaic Acid	toxin catabolic process	NADP	[NADP results in increased toxin catabolic process] which results in increased metabolism of Okadaic Acid	2: Homo sapiens \| Rattus norvegicus	Liver \| Subcellular Fractions		1
30.	Okadaic Acid	protein serine/threonine phosphatase activity	SLCO1B3	[SLCO1B3 protein results in increased susceptibility to Okadaic Acid] which results in decreased protein serine/threonine phosphatase activity	1: Homo sapiens	HEK293 Cells	5 genes: PPP1CA \| PPP2CA \| PPP2R1A \| PPP4C \| PPP5C	1
31.	Okadaic Acid	apoptotic process		Okadaic Acid results in increased apoptotic process	1: Homo sapiens	U937 Cells	53 genes: ABL1 \| AKT1 \| APP \| BAX \| BBC3 \| BCL2 \| BCL2L11 \| BCL2L14 \| CASP10 \| CASP3 \| CASP7 \| CASP8 \| CASP9 \| CDK1 \| DAB2 \| DDIT3 \| EGLN3 \| EP300 \| ERN1 \| FIS1 \| FOXO3 \| GAPDH \| GJA1 \| HTRA2 \| IER3 \| IL1B \| ITPR1 \| JAK2 \| MAP3K10 \| MAPK1 \| MAPK3 \| MAPT \| MFN2 \| NFKB1 \| NFKBIA \| NR3C1 \| OPA1 \| PARP1 \| PPP2CA \| PPP2R1A \| PRDX5 \| RAD21 \| RAF1 \| RB1 \| RPS6KB1 \| TAX1BP1 \| TF \| TNF \| TNFSF10 \| TP53 \| TRP53 \| UBE2D3 \| XBP1	1
32.	Okadaic Acid	regulation of vascular permeability	mustard oil \| sodium arsenite	Okadaic Acid inhibits the reaction [sodium arsenite promotes the reaction [mustard oil affects regulation of vascular permeability]]	1: Mus musculus	Microvessels		1
33.	Okadaic Acid	intracellular distribution of mitochondria		Okadaic Acid affects intracellular distribution of mitochondria	1: Rattus norvegicus	Brain \| Endothelial Cells \| Cell Line	6 genes: CLU \| DNM1L \| MAPT \| MFN1 \| MFN2 \| OPA1	1
34.	Okadaic Acid	glutathione biosynthetic process	Quercetin	Quercetin inhibits the reaction [Okadaic Acid results in decreased glutathione biosynthetic process]	1: Mus musculus	Hippocampus \| Cell Line		1
35.	Okadaic Acid	positive regulation of NF-kappaB transcription factor activity	SOD2	SOD2 protein inhibits the reaction [Okadaic Acid results in increased positive regulation of NF-kappaB transcription factor activity]	1: Homo sapiens	MCF-7 Cells	9 genes: AGT \| APP \| CLU \| IL1B \| IRAK1 \| NFKB1 \| RELA \| TNF \| UBC	1
36.	Okadaic Acid	cell death		Okadaic Acid results in increased cell death	1: Mus musculus	Hippocampus \| Cell Line	1 gene: MAP3K10	1
37.	Okadaic Acid	positive regulation of NF-kappaB transcription factor activity		Okadaic Acid results in increased positive regulation of NF-kappaB transcription factor activity	1: Homo sapiens	MCF-7 Cells	9 genes: AGT \| APP \| CLU \| IL1B \| IRAK1 \| NFKB1 \| RELA \| TNF \| UBC	1
38.	Okadaic Acid	activation of protein kinase B activity		Okadaic Acid results in increased activation of protein kinase B activity	1: Homo sapiens	Prostate \| Cell Line, Tumor	3 genes: AKT1 \| IGF1 \| TXN	1
39.	Okadaic Acid	positive regulation of cell death	CYP3A23/3A1	CYP3A23/3A1 protein inhibits the reaction [Okadaic Acid results in increased positive regulation of cell death]	1: Rattus norvegicus	Hep G2 Cells	10 genes: ACOX2 \| BCL2L11 \| EGR1 \| EP300 \| GRIN1 \| HTRA2 \| IL1B \| PDX1 \| PTGS2 \| UCP2	1
40.	Okadaic Acid	positive regulation of ion transmembrane transporter activity	Rubidium \| staurosporine aglycone	staurosporine aglycone inhibits the reaction [[Okadaic Acid results in increased positive regulation of ion transmembrane transporter activity] which results in increased uptake of Rubidium]	1: Anas platyrhynchos	Erythrocytes		1
41.	Okadaic Acid	lipid catabolic process		Okadaic Acid results in increased lipid catabolic process	1: Mus musculus	Hippocampus \| Cell Line	4 genes: CES1D \| LPL \| PLA2G4A \| PRDX6	1
42.	Okadaic Acid	positive regulation of cell death		Okadaic Acid results in increased positive regulation of cell death	1: Homo sapiens	Hep G2 Cells	10 genes: ACOX2 \| BCL2L11 \| EGR1 \| EP300 \| GRIN1 \| HTRA2 \| IL1B \| PDX1 \| PTGS2 \| UCP2	2
43.	Okadaic Acid	positive regulation of ion transmembrane transporter activity	Norepinephrine \| Propranolol	Okadaic Acid inhibits the reaction [Propranolol inhibits the reaction [Norepinephrine results in increased positive regulation of ion transmembrane transporter activity]]	1: Anas platyrhynchos	Erythrocytes		1
44.	Okadaic Acid	cellular response to xenobiotic stimulus		Okadaic Acid results in increased cellular response to xenobiotic stimulus	2: Homo sapiens \| Scrobicularia plana	COS Cells	3 genes: GSTP1 \| PCNA \| RB1	1
45.	Okadaic Acid	positive regulation of ion transmembrane transporter activity	Bumetanide	Bumetanide inhibits the reaction [Okadaic Acid results in increased positive regulation of ion transmembrane transporter activity]	1: Anas platyrhynchos	Erythrocytes		1
46.	Okadaic Acid	protein serine/threonine phosphatase activity	SLCO1B1 \| Sulfobromophthalein	Sulfobromophthalein inhibits the reaction [[SLCO1B1 protein results in increased susceptibility to Okadaic Acid] which results in decreased protein serine/threonine phosphatase activity]	1: Homo sapiens	HEK293 Cells	5 genes: PPP1CA \| PPP2CA \| PPP2R1A \| PPP4C \| PPP5C	1
47.	Okadaic Acid	cell migration		Okadaic Acid results in decreased cell migration	1: Homo sapiens	Cell Line, Tumor	11 genes: CD44 \| CDK1 \| CXCL12 \| FGFR4 \| GSK3B \| MMP2 \| PDGFRA \| PODXL \| RPS6KB1 \| THBS1 \| VEGFA	1
48.	Okadaic Acid	glutathione biosynthetic process		Okadaic Acid results in decreased glutathione biosynthetic process	1: Mus musculus	Hippocampus \| Cell Line		1
49.	Okadaic Acid	positive regulation of ion transmembrane transporter activity	Rubidium	[Okadaic Acid results in increased positive regulation of ion transmembrane transporter activity] which results in increased uptake of Rubidium	1: Anas platyrhynchos	Erythrocytes		1
50.	Okadaic Acid	positive regulation of cell death	CYP3A2	CYP3A2 protein promotes the reaction [Okadaic Acid results in increased positive regulation of cell death]	1: Rattus norvegicus	Hep G2 Cells	10 genes: ACOX2 \| BCL2L11 \| EGR1 \| EP300 \| GRIN1 \| HTRA2 \| IL1B \| PDX1 \| PTGS2 \| UCP2	1

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