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Chemical Buthionine Sulfoximine

Name Buthionine Sulfoximine
CAS Type 1 Name Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-
Equivalent Term Sulfoximine, Buthionine
CAS Registry Number 5072-26-4
Definition A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)
Structure Buthionine Sulfoximine
Top Interacting
Genes
MeSH® ID D019328
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Top ↑ Ancestors

ChemicalsOrganic Chemicals Has associated genes Has associated diseases Has associated exposure references Sulfur Compounds Has associated genes Has associated diseases Has associated exposure references Amino Acids, Sulfur Has associated genes Has associated diseases Has associated exposure references Methionine Has associated genes Has associated diseases Methionine Sulfoximine Has associated genes Has associated diseases Buthionine Sulfoximine Has associated genes Has associated diseases

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None.