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Chemical 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid

Name 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
Equivalent Terms 12-HETE | 12-R-HETE | 12-S-HETE | 12 S Hydroxyeicosatetraenoic Acid | 12-S-Hydroxyeicosatetraenoic Acid | Acid, 12-S-Hydroxyeicosatetraenoic
CAS Registry Number 59985-28-3
Definition A lipoxygenase metabolite of ARACHIDONIC ACID. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (J Pharmacol Exp Ther 1995; 274(3):1545-51; J Natl Cancer Inst 1994; 86(15):1145-51)
Structure 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
Top Interacting
Genes
MeSH® ID D019377
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Top ↑ Ancestors

1. ChemicalsLipids Has associated genes Has associated diseases Has associated exposure references Fatty Acids Has associated genes Has associated diseases Has associated exposure references Fatty Acids, Unsaturated Has associated genes Has associated diseases Has associated exposure references Eicosanoids Has associated genes Has associated diseases Has associated exposure references Arachidonic Acids Has associated genes Has associated diseases Has associated exposure references Hydroxyeicosatetraenoic Acids Has associated genes Has associated diseases Has associated exposure references 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid Has associated genes Has associated diseases Has associated exposure references
2. ChemicalsLipids Has associated genes Has associated diseases Has associated exposure references Fatty Acids Has associated genes Has associated diseases Has associated exposure references Fatty Acids, Unsaturated Has associated genes Has associated diseases Has associated exposure references Fatty Acids, Essential Has associated genes Has associated diseases Has associated exposure references Arachidonic Acids Has associated genes Has associated diseases Has associated exposure references Hydroxyeicosatetraenoic Acids Has associated genes Has associated diseases Has associated exposure references 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid Has associated genes Has associated diseases Has associated exposure references

Top ↑ Descendants

12-Hydroxy-5,8,10,14-eicosatetraenoic Acid Has associated genes Has associated diseases Has associated exposure references
  12,13-dihydroxy-5,8,10,14-eicosatetraenoic acid
  12,20-dihydroxy-5,8,10,14-eicosatetraenoic acid Has associated diseases