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Chemical Disintegrins

Name Disintegrins
Definition A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to integrin receptors and thus competitively inhibits normal integrin-ligand interactions. Disintegrins thus block adhesive functions and act as platelet aggregation inhibitors.
Curation Status No associations have been curated for this chemical yet.
MeSH® ID D019483
External Links

Top ↑ Ancestors

ChemicalsAmino Acids, Peptides, and Proteins Has associated genes Has associated diseases Has associated exposure references Peptides Has associated genes Has associated diseases Has associated exposure references Disintegrins

Top ↑ Descendants

Disintegrins
  accutin
  acostatin
  acurhagin-C protein, Agkistrodon acutus
  adinbitor protein, Agkistrodon halys brevicaudus stejneger
  alternagin-C
  bitisgabonin-1
  bitisgabonin-2
  bothrostatin, Bothrops jararaca
  contortrostatin
  cumanastatin 1, Crotalus durissus cumanensis
  DisBa-01, Bothrops alternatus
  EC3 protein, Echis carinatus
  EC6 protein, Echis carinatus sochureki
  EMF10 protein, Eristocophis macmahoni
  flavorodin
  flavostatin
  insularin, Bothrops insularis
  jarastatin
  jerdonin
  jerdostatin, Protobothrops jerdonii
  kuzbanian protein, Drosophila
  lebestatin protein, Macrovipera lebetina
  MIG-17 protein, C elegans
  mojastin protein, Crotalus scutulatus
  ocellatusin
  piscivostatin
  saxatilin
  stejnin protein, Trimeresurus stejnegeri
  trimestatin protein, Trimeresurus flavoviridis
  ussuristatin 1 protein, Gloydius ussuriensis
  ussuristatin 2 protein, Gloydius ussuriensis
  vicrostatin