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Chemical Kininogen, High-Molecular-Weight

Name Kininogen, High-Molecular-Weight
Equivalent Terms Fitzgerald Factor | High Molecular Weight Kininogen | High-Molecular-Weight Kininogen | High Molecular Weight Kininogens | High-Molecular-Weight Kininogens | HMWK | Kininogen, High Molecular Weight | Kininogens, High Molecular Weight | Kininogens, High-Molecular-Weight
Definition A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed)
Curation Status No associations have been curated for this chemical yet.
MeSH® ID D019679
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1. ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Blood Coagulation Factors Has associated genes Has associated diseases Has associated exposure references Kininogens Kininogen, High-Molecular-Weight
2. ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Inflammation Mediators Has associated genes Has associated diseases Has associated exposure references Autacoids Has associated genes Has associated diseases Has associated exposure references Kinins Has associated genes Has associated diseases Kininogens Kininogen, High-Molecular-Weight
3. ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Intercellular Signaling Peptides and Proteins Has associated genes Has associated diseases Kinins Has associated genes Has associated diseases Kininogens Kininogen, High-Molecular-Weight

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Kininogen, High-Molecular-Weight
  HKa protein, human