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Chemical Simvastatin

Name Simvastatin
Equivalent Terms MK733 | MK 733 | MK-733 | Synvinolin | Zocor
CAS Registry Number 79902-63-9
Definition A derivative of LOVASTATIN and potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL RECEPTORS, it increases breakdown of LDL CHOLESTEROL.
Structure Simvastatin
Top Interacting
Genes
MeSH® ID D019821
External Links

Top ↑ Ancestors

1. ChemicalsOrganic Chemicals Has associated genes Has associated diseases Has associated exposure references Hydrocarbons Has associated genes Has associated diseases Has associated exposure references Hydrocarbons, Cyclic Has associated genes Has associated diseases Has associated exposure references Hydrocarbons, Aromatic Has associated genes Has associated diseases Has associated exposure references Polycyclic Hydrocarbons, Aromatic Has associated genes Has associated diseases Has associated exposure references Naphthalenes Has associated genes Has associated diseases Has associated exposure references Lovastatin Has associated genes Has associated diseases Simvastatin Has associated genes Has associated diseases
2. ChemicalsPolycyclic Compounds Has associated genes Has associated diseases Has associated exposure references Polycyclic Hydrocarbons, Aromatic Has associated genes Has associated diseases Has associated exposure references Naphthalenes Has associated genes Has associated diseases Has associated exposure references Lovastatin Has associated genes Has associated diseases Simvastatin Has associated genes Has associated diseases

Top ↑ Descendants

Simvastatin Has associated genes Has associated diseases
  6-(2-(8-(2,2-dimethylbutyryl)oxy)-2,6-dimethyl-5-hydroxy-1,2,3,4,4a,5,6,7,8,8a-decahydronaphthyl-1-ethyl)-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one
  beta-hydroxy simvastatin acid Has associated genes Has associated diseases
  Ezetimibe, Simvastatin Drug Combination Has associated diseases
  Simcor
  simvaglyzin
  simvastatin acid Has associated genes Has associated diseases
  simvastatin hydroxyacid Has associated genes Has associated diseases