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Chemical Sirolimus

Name Sirolimus
Equivalent Terms AY 22989 | AY 22 989 | AY 22-989 | I2190A | I 2190A | I-2190A | Rapamune | Rapamycin
CAS Registry Number 53123-88-9
Definition A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.
Structure Sirolimus
Top Interacting
Genes
MeSH® ID D020123
External Links

Top ↑ Ancestors

ChemicalsOrganic Chemicals Has associated genes Has associated diseases Has associated exposure references Lactones Has associated genes Has associated diseases Has associated exposure references Macrolides Has associated genes Has associated diseases Has associated exposure references Sirolimus Has associated genes Has associated diseases

Top ↑ Descendants

Sirolimus Has associated genes Has associated diseases
  15-deoxo-7,32-O-didesmethylrapamycin
  AP 21967
  demethoxyrapamycin
View node Everolimus Has associated genes Has associated diseases
  homotemsirolimuse A
  homotemsirolimuse B
  homotemsirolimuse C
  pre-rapamycin
  rapamycin-28-N,N-dimethylglycinate
  rapamycin tris-epoxide metabolite
  ridaforolimus
  SAR943
  SDZ RAD 223-756
  temsirolimus Has associated genes Has associated diseases
  triolimus
  umirolimus
  WAY 124466
  zotarolimus Has associated genes Has associated diseases