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Chemical Neural Cell Adhesion Molecule L1

Name Neural Cell Adhesion Molecule L1
Equivalent Terms CALL Protein | CamL1 Gene Product | Cell Adhesion Molecule L1 | Cell Surface Glycoprotein L1 | F11 Glycoprotein | Glycoprotein, NGF-Inducible | Glycoprotein, NILE | L1CAM | L1 Cell Adhesion Molecule | Nerve Growth Factor Inducible Large External Glycoprotein | Nerve Growth Factor-Inducible Large External Glycoprotein | Neural Adhesion Molecule L1 | NGF Inducible Glycoprotein | NGF-Inducible Glycoprotein | NILE Glycoprotein | NILE Protein
Definition A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.
Curation Status No associations have been curated for this chemical yet.
MeSH® ID D039842
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Top ↑ Ancestors

ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Antigens Has associated genes Has associated diseases Has associated exposure references Antigens, Surface Has associated genes Has associated diseases Cell Adhesion Molecules Has associated diseases Cell Adhesion Molecules, Neuronal Neural Cell Adhesion Molecules Neural Cell Adhesion Molecule L1

Top ↑ Descendants

Neural Cell Adhesion Molecule L1
  avian glycoprotein 50-kDa
  LAD-2 protein, C elegans
  NCAM2 protein, human
  polysialyl neural cell adhesion molecule