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Chemical Ectodysplasins

Name Ectodysplasins
Equivalent Terms Ectodysplasin | Ectodysplasin A | Ectodysplasin-A | Ectodysplasin A1 | Ectodysplasin A2 | Ectodysplasin A, Isoform 1 | Ectodysplasin A, Isoform 2
Definition Transmembrane proteins belonging to the tumor necrosis factor superfamily that play an essential role in the normal development of several ectodermally derived organs. Several isoforms of the ectodysplasins exist due to multiple ALTERNATIVE SPLICING of the MRNA for the protein. The isoforms ectodysplasin A1 and ectodysplasin A2 are considered biologically active and each bind distinct ECTODYSPLASIN RECEPTORS. Genetic mutations that result in loss of function of ectodysplasin result in ECTODERMAL DYSPLASIA 1, ANHIDROTIC.
Curation Status No associations have been curated for this chemical yet.
MeSH® ID D053331
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Top ↑ Ancestors

ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Intercellular Signaling Peptides and Proteins Has associated genes Has associated diseases Cytokines Has associated genes Has associated diseases Tumor Necrosis Factors Ectodysplasins

Top ↑ Descendants

  EDA protein, human
  Eda protein, mouse