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Chemical Agouti Signaling Protein

Name Agouti Signaling Protein
Equivalent Terms Agouti Protein | Agouti Switch Protein | ASIP Protein
Definition A secreted protein of approximately 131 amino acids (depending on species) that regulates the synthesis of eumelanin (brown/black) pigments in MELANOCYTES. Agouti protein antagonizes the signaling of MELANOCORTIN RECEPTORS and has wide distribution including ADIPOSE TISSUE; GONADS; and HEART. Its overexpression in agouti mice results in uniform yellow coat color, OBESITY, and metabolic defects similar to type II diabetes in humans.
Curation Status No associations have been curated for this chemical yet.
MeSH® ID D054366
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Top ↑ Ancestors

ChemicalsBiological Factors Has associated genes Has associated diseases Has associated exposure references Intercellular Signaling Peptides and Proteins Has associated genes Has associated diseases Agouti Signaling Protein

Top ↑ Descendants

Agouti Signaling Protein
  ASIP protein, human
  Asip protein, rat
  nonagouti protein, mouse