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Chemical Growth Differentiation Factor 1

Name Growth Differentiation Factor 1
Equivalent Term GDF-1
Definition A growth differentiation factor that plays a role in the genesis of left-right asymmetry during vertebrate development. Evidence for this role is seen in MICE where loss of growth differentiation factor 1 function results in right-left isomerism of visceral organs. In HUMANS heterozygous loss of growth differentiation factor 1 function has been associated with CONGENITAL HEART DEFECTS and TRANSPOSITION OF GREAT VESSELS.
Curation Status No associations have been curated for this chemical yet.
MeSH® ID D055452
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Top ↑ Ancestors

1. ChemicalsBiological Factors Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references Intercellular Signaling Peptides and Proteins Has associated genes Has associated diseases Has associated phenotype references TGF-beta Superfamily Proteins Growth Differentiation Factors Growth Differentiation Factor 1
2. ChemicalsBiological Factors Has associated genes Has associated diseases Has associated phenotype references Has associated exposure references Intercellular Signaling Peptides and Proteins Has associated genes Has associated diseases Has associated phenotype references TGF-beta Superfamily Proteins Nodal Signaling Ligands Growth Differentiation Factor 1

Top ↑ Descendants

Growth Differentiation Factor 1
  GDF1 protein, human
  Gdf1 protein, mouse
  Gdf1 protein, rat