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Chemical CLOCK Proteins

Name CLOCK Proteins
Equivalent Terms Circadian Locomotor Output Cycles Kaput Proteins | CLOCK Protein
Definition Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.
Curation Status No associations have been curated for this chemical yet.
MeSH® ID D056926
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Top ↑ Ancestors

ChemicalsAmino Acids, Peptides, and Proteins Has associated genes Has associated diseases Has associated exposure references Peptides Has associated genes Has associated diseases Has associated exposure references Circadian Rhythm Signaling Peptides and Proteins CLOCK Proteins

Top ↑ Descendants

CLOCK Proteins
  Clk protein, Drosophila
  CLOCK protein, human
  Clock protein, mouse
  Clock protein, rat