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Disease Congenital Abnormalities

These are exposure studies associated with the disease and all of its children.

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1–25 of 25 results.
  Reference Associated Study Title Author's Summary Study Factors Stressor Receptors Country Medium Exposure Marker Measurements Outcome
1. Rull RP, et al. (2006). Data on two case-control study populations of infants with neural tube defects (NTDs) and nonmalformed controls delivered in California between 1987 and 1991 were pooled to investigate whether maternal residential proximity to applications of specific pesticides or physicochemical groups of pesticides during early gestation increases the risk of these malformations. 1,3-dichloro-1-propene | Amides | Benomyl | Benzimidazoles | Captan | Chlorpyrifos | devrinol | Dimethoate | Disulfoton | Methomyl | methyl carbamate | methyl demeton | Naled | Organophosphorus Compounds | vendex Infants or newborns United States 1,3-dichloro-1-propene | Amides | Benomyl | Benzimidazoles | Captan | Chlorpyrifos | devrinol | Dimethoate | Disulfoton | Methomyl | methyl carbamate | methyl demeton | Naled | Organophosphorus Compounds | vendex Details Anencephaly | Neural Tube Defects | Spinal Dysraphism
2. Main KM, et al. (2007). Two different proxies were used for prenatal polybrominated diphenyl ethers exposure, and levels in breast milk, but not in placenta, showed an association with congenital cryptorchidism. 2,2',3,4,4',5',6-heptabromodiphenyl ether | 2,2',4,4',5,5'-hexabrominated diphenyl ether | 2,2',4,4'-tetrabromodiphenyl ether | Halogenated Diphenyl Ethers | hexabromodiphenyl ether 154 | pentabromodiphenyl ether | tribromodiphenyl ether 28 Infants or newborns | Mothers Denmark|Finland milk, human | placenta 2,2',3,4,4',5',6-heptabromodiphenyl ether | 2,2',4,4',5,5'-hexabrominated diphenyl ether | 2,2',4,4'-tetrabromodiphenyl ether | Halogenated Diphenyl Ethers | hexabromodiphenyl ether 154 | pentabromodiphenyl ether | tribromodiphenyl ether 28 Details Cryptorchidism
3. Cordier S, et al. (2004). Several groups of congenital anomalies, in particular obstructive uropathies, appear to occur more often than expected in populations living around municipal solid waste incinerators. Air Pollutants Study subjects France Details Abnormalities, Drug-Induced | Congenital Abnormalities | Skin Abnormalities
4. Li Z, et al. (2011). Compared with women with no indoor air pollution from coal combustion exposure, women with any exposure at all had a 60% increased risk of having a child with an neural tube defects. An increased risk was linked to both residential heating and cooking. This is the first known study to link indoor air pollution from coal combustion to neural tube defects. Air Pollutants | Coal | Smoke Study subjects China Details Neural Tube Defects
5. Liu CB, et al. (2016). Our findings suggest some positive associations between maternal exposure to ambient particulate matter (PM10) during the first two months of pregnancy and fetal cardiovascular malformations. Air Pollutants | Particulate Matter Infants or newborns | Pregnant females China air, ambient Particulate Matter Details Cardiovascular Abnormalities | Ductus Arteriosus, Patent | Heart Septal Defects, Atrial | Heart Septal Defects, Ventricular | Tetralogy of Fallot
6. Al-Sabbak M, et al. (2012). Our data suggested that birth defects in the Iraqi cities of Al Basrah and Fallujah are mainly folate-dependent. This knowledge offers possible treatment options and remediation plans for at-risk Iraqi populations. Aluminum | Arsenic | Cadmium | Chromium | Cobalt | Copper | Iron | Lead | Manganese | Mercury | Molybdenum | Nickel | Selenium | Thorium | Uranium | Vanadium | Zinc Children | Controls for disease:Congenital Abnormalities | Subjects with disease:Congenital Abnormalities | Study subjects Brazil|Canada|
Ethiopia|India|
Iraq|Mexico|
Norway|Pakistan|
Poland|Spain|
Turkey|United States
hair | nail | tooth Aluminum | Arsenic | Cadmium | Chromium | Cobalt | Copper | Iron | Lead | Manganese | Mercury | Molybdenum | Nickel | Selenium | Thorium | Uranium | Vanadium | Zinc Details
7. Fénichel P, et al. (2012). The presence of unconjugated bisphenol A in all cord blood samples suggests placental transfer and fetal exposure. Androstenedione | bisphenol A | Estradiol | Estriol | Estrone | Testosterone Controls for disease:Cryptorchidism | Subjects with disease:Cryptorchidism | Infants or newborns France blood, cord Androstenedione | bisphenol A | Estradiol | Estriol | Estrone | Testosterone Details
8. Cui N, et al. (2016). Long-term exposure to arsenic is associated with upregulated mRNA expression for genes AHR and CYP1A1 in the blood, and blood CYP1A1 mRNA (but not AHR mRNA) is associated with prolonged corrected QT interval. diet Arsenic Study subjects China blood | water, drinking AHR | Arsenic | CYP1A1 Details Long QT Syndrome | regulation of heart rate
9. Mumford JL, et al. (2007). We found significant association between chronic arsenic exposure and QT interval prolongation in a human population. sex Arsenic Study subjects China nail Arsenic Details Cardiovascular Abnormalities | regulation of heart contraction
10. Zhang A, et al. (2007). The results showed that long-term Arsenic exposure may be associated with damage of chromosomes and DNA, gene mutations, gene deletions, and alterations of DNA synthesis and repair ability. Arsenic Subjects with disease:Carcinoma | Subjects with disease:Ichthyosis | Subjects with disease:Precancerous Conditions | Study subjects China hair | urine Arsenic Details Arsenic Poisoning | DNA biosynthetic process | DNA repair | gene expression
11. Sanders AP, et al. (2014). In the present study we examined private well water levels of arsenic, cadmium, manganese, and lead across North Carolina, and used a semi-ecologic study design to estimate the association between metal levels and specific birth defect phenotypes. Arsenic | Cadmium | Lead | Manganese Infants or newborns United States Arsenic | Cadmium | Lead | Manganese Details Cleft Lip | Congenital Microtia | Conotruncal cardiac defects | Hypoplastic Left Heart Syndrome | Pyloric Stenosis
12. Pierik FH, et al. (2007). Collaborative Perinatal Project (CPP) These results provide little support for an association of cryptorchidism with exposure to low levels of heptachlor epoxide or hexachlorobenzene. For beta-hexachlorocyclohexane the findings were somewhat suggestive of an association but were inconclusive. beta-hexachlorocyclohexane | Dichlorodiphenyl Dichloroethylene | Heptachlor Epoxide | Hexachlorobenzene Pregnant females United States serum beta-hexachlorocyclohexane | Dichlorodiphenyl Dichloroethylene | Heptachlor Epoxide | Hexachlorobenzene Details Cryptorchidism
13. Wright JM, et al. (2017). This is the first epidemiological study of birth defects and disinfection by-products (DBPs) to examine several individual cardiovascular defects, different exposure surrogate mixtures (sum of chloroform, bromoform, bromodichloromethane, and dibromochloromethane (THM4), brominated trihalomethanes, sum of monochloroacetic acid, dichloroacetic acid, trichloroacetic acid, monobromoacetic acid, and dibromoacetic acid (HAA5), sum of THM4 and HAA5, and various individual DBP species. sex bromoacetate | bromodichloromethane | bromoform | chloroacetic acid | chlorodibromomethane | Chloroform | dibromoacetic acid | Dichloroacetic Acid | Trichloroacetic Acid Fetuses | Pregnant females United States water, drinking Acetates | bromoacetate | bromodichloromethane | bromoform | chloroacetic acid | chlorodibromomethane | Chloroform | dibromoacetic acid | Dichloroacetic Acid | Trichloroacetic Acid | Trihalomethanes Details Cardiovascular Abnormalities | Heart Septal Defects, Atrial | Heart Septal Defects, Ventricular | Pulmonary Valve Stenosis | Tetralogy of Fallot | Transposition of Great Vessels
14. Gilboa SM, et al. (2005). A population-based case-control study investigated the association between maternal exposure to air pollutants, carbon monoxide, nitrogen dioxide, ozone, sulfur dioxide, and particulate matter <10 microns in aerodynamic diameter during weeks 3-8 of pregnancy and the risk of selected cardiac birth defects and oral clefts in livebirths and fetal deaths between 1997 and 2000 in seven Texas counties. sex Carbon Monoxide | Nitrogen Dioxide | Ozone | Particulate Matter | Sulfur Dioxide Children United States Details Cleft Lip | Cleft Palate | Conotruncal cardiac defects | Endocardial Cushion Defects | Heart Septal Defects, Atrial | Heart Septal Defects, Ventricular | Tetralogy of Fallot
15. Shirangi A, et al. (2014). Health Risks of Australian Veterinarians Study (HRAV) This study suggests that the adverse effects of handling cytotoxic drugs in pregnant women may include an increased risk of birth defects. Cytotoxins Pregnant females Australia Details Congenital Abnormalities | Prenatal Exposure Delayed Effects
16. Bentov Y, et al. (2006). Residential proximity to the IP is associated with increased rates of MCM among Arab-Beduin but not in Jewish populations. Environmental Pollutants | Hazardous Waste Infants or newborns Israel Details Congenital Abnormalities
17. Amin R, et al. (2017). We find that gadolinium use during pregnancy is unlikely to be associated with adverse effects in infants during the neonatal period. Gadolinium Infants or newborns | Pregnant females United States blood, cord Gadolinium Details Birth Weight | Bone Diseases, Metabolic | Chorioamnionitis | Diabetes, Gestational | Ductus Arteriosus, Patent | Enterocolitis, Necrotizing | Fetal Growth Retardation | Hyperbilirubinemia, Neonatal | Hypertension, Pregnancy-Induced | Lung Diseases | Obstetric Labor, Premature | Oligohydramnios | Prenatal Exposure Delayed Effects | Respiratory Distress Syndrome, Newborn | Retinopathy of Prematurity
18. Schreinemachers DM. (2003). Results from this study indicate that in rural, agricultural counties where wheat acreage occupies a larger percentage of the land and where use of chlorophenoxy herbicides is higher, anomalies of the circulatory/respiratory and musculoskeletal/integumental system significantly increased. sex Herbicides Infants or newborns United States Details Congenital Abnormalities
19. Chevrier C, et al. (2011). PELAGIE This study is the first to assess associations of birth outcomes with multiple urinary biomarkers of exposure to triazine and chloroacetanilide herbicides. Evidence of associations with adverse birth outcomes raises particular concerns for countries where atrazine is still in use. Herbicides Fetuses | Pregnant females France urine 2,6-diethylaniline | acetochlor | alachlor | ammeline | Atrazine | atrazine mercapturate | Creatinine | desethylatrazine | metolachlor | Simazine Details Congenital Abnormalities | Fetal Growth Retardation | Pregnancy Complications | head development
20. Savabieasfahani M, et al. (2015). Exposure to mixtures of metals that can result from high-temperature explosions of war may have additive or synergistic effects that can alter toxicity, especially in developing children; a spectrum of neurodevelopmental disorders are appearing in Iraqi cities where bombing and military events have led to increased public exposures to toxic metals. Magnesium | Metals | Titanium Children | Controls for disease:Congenital Abnormalities | Subjects with disease:Congenital Abnormalities | Controls for disease:Neurodevelopmental Disorders | Subjects with disease:Neurodevelopmental Disorders Iran, Islamic Republic of|Iraq hair Aluminum | Arsenic | Cadmium | Chromium | Cobalt | Copper | Iron | Lead | Magnesium | Manganese | Mercury | Molybdenum | Nickel | Selenium | Titanium | Uranium | Vanadium | Zinc Details
21. Scheers H, et al. (2011). Even in an affluent region in Western Europe, where infant mortality is low, days with higher Particulate Matter air pollution are associated with an increased risk of infant mortality. Particulate Matter Infants or newborns Belgium Particulate Matter Details Chromosome Aberrations | Congenital Abnormalities
22. Toft G, et al. (2016). Environmental perfluorooctane sulfonate exposure was associated with steroid hormone and INSL3 concentrations in amniotic fluid, but was not associated with cryptorchidism or hypospadias in our study population. perfluorooctane sulfonic acid Pregnant females Denmark amniotic fluid 17-alpha-Hydroxyprogesterone | Androstenedione | Dehydroepiandrosterone Sulfate | Hydrocortisone | INSL3 | Progesterone | Testosterone Details Cryptorchidism | Hypospadias | regulation of gene expression | regulation of testosterone biosynthetic process
23. Carmichael SL, et al. (2016). This study indicates that babies with genetic variants and maternal pesticide exposures who were previously identified as associated with increased risk of hypospadias were at two- to fourfold increased risk of hypospadias. genetics Pesticides Subjects with gene influence:DGKK | Controls for disease:Hypospadias | Subjects with disease:Hypospadias | Infants or newborns United States Details Hypospadias
24. Hwang BF, et al. (2008). The present study suggests that prenatal exposure to disinfection by-products increases the risk of ventricular septal defects, cleft palate, and anencephalus. Trihalomethanes Infants or newborns Taiwan, Province of China Trihalomethanes Details Anencephaly | Cleft Palate | Heart Septal Defects, Ventricular
25. Thun MJ, et al. (1982). Families exposed to urea-formaldehyde foam insulation reported no increase in the overall incidence of symptoms, but did report a significant excess of two specific symptoms, 'burning skin' and 'wheezing or difficulty breathing'. urea formaldehyde foam Study subjects United States Details Pain | Respiratory Sounds | Skin Abnormalities
1–25 of 25 results.