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Disease Amyotrophic Lateral Sclerosis

Name Amyotrophic Lateral Sclerosis
Synonyms ALS (Amyotrophic Lateral Sclerosis) | Amyotrophic Lateral Sclerosis, Guam Form | Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1 | Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1 | Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam | Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam | Amyotrophic Lateral Sclerosis With Dementia | Charcot Disease | Dementia With Amyotrophic Lateral Sclerosis | Disease, Guam | Disease, Lou-Gehrigs | Gehrig Disease | Gehrig's Disease | Gehrigs Disease | Guam Disease | Guam Form of Amyotrophic Lateral Sclerosis | Lou Gehrig Disease | Lou Gehrig's Disease | Lou-Gehrigs Disease | Motor Neuron Disease, Amyotrophic Lateral Sclerosis | Sclerosis, Amyotrophic Lateral
Definition A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
Categories Metabolic disease | Nervous system disease
MeSH® ID D000690
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Top ↑ Ancestors

1. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Central Nervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Spinal Cord Diseases Has associated chemicals Has associated genes Has associated exposure references Amyotrophic Lateral Sclerosis Has associated chemicals Has associated genes Has associated exposure references
2. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Neurodegenerative Diseases Has associated chemicals Has associated genes Has associated exposure references Motor Neuron Disease Has associated chemicals Has associated genes Has associated exposure references Amyotrophic Lateral Sclerosis Has associated chemicals Has associated genes Has associated exposure references
3. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Neurodegenerative Diseases Has associated chemicals Has associated genes Has associated exposure references TDP-43 Proteinopathies Has associated chemicals Has associated genes Has associated exposure references Amyotrophic Lateral Sclerosis Has associated chemicals Has associated genes Has associated exposure references
4. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Neuromuscular Diseases Has associated chemicals Has associated genes Has associated exposure references Motor Neuron Disease Has associated chemicals Has associated genes Has associated exposure references Amyotrophic Lateral Sclerosis Has associated chemicals Has associated genes Has associated exposure references
5. DiseasesNutritional and Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Proteostasis Deficiencies Has associated chemicals Has associated genes Has associated exposure references TDP-43 Proteinopathies Has associated chemicals Has associated genes Has associated exposure references Amyotrophic Lateral Sclerosis Has associated chemicals Has associated genes Has associated exposure references

Top ↑ Descendants

Amyotrophic Lateral Sclerosis Has associated chemicals Has associated genes Has associated exposure references
  Amyotrophic lateral sclerosis 1 Has associated chemicals Has associated genes
  Amyotrophic Lateral Sclerosis 10 Has associated chemicals Has associated genes
  Amyotrophic Lateral Sclerosis 11 Has associated chemicals Has associated genes
  AMYOTROPHIC LATERAL SCLEROSIS 12 Has associated chemicals Has associated genes
  Amyotrophic Lateral Sclerosis 2, Juvenile Has associated chemicals Has associated genes
  Amyotrophic Lateral Sclerosis 3
  Amyotrophic Lateral Sclerosis 4, Juvenile Has associated chemicals Has associated genes
  Amyotrophic Lateral Sclerosis 5 Has associated chemicals Has associated genes
  Amyotrophic Lateral Sclerosis 6, Autosomal Recessive Has associated chemicals Has associated genes
  Amyotrophic Lateral Sclerosis 7
  Amyotrophic Lateral Sclerosis 8 Has associated chemicals Has associated genes
  Amyotrophic Lateral Sclerosis 9 Has associated chemicals Has associated genes
  Amyotrophic Lateral Sclerosis, Autosomal Recessive
  Amyotrophic Lateral Sclerosis, Chmp2B-Related
  Amyotrophic Lateral Sclerosis, Juvenile, with Dementia
  AMYOTROPHIC LATERAL SCLEROSIS-PARKINSONISM/DEMENTIA COMPLEX 1 Has associated chemicals Has associated genes
  Amyotrophic lateral sclerosis, type 6
  Amyotrophic Lateral Sclerosis With Polyglucosan Bodies
  FRONTOTEMPORAL DEMENTIA AND/OR AMYOTROPHIC LATERAL SCLEROSIS 1 Has associated chemicals Has associated genes
  Frontotemporal Dementia With Motor Neuron Disease Has associated chemicals Has associated genes