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Disease Arterial Occlusive Diseases

These are exposure studies associated with the disease and all of its children.

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1–23 of 23 results.
  Reference Associated Study Title Author's Summary Study Factors Stressor Receptors Country Medium Exposure Marker Measurements Outcome
1. Künzli N, et al. (2010). B-Vitamin Atherosclerosis Intervention Trial (BVAIT) | Estrogen in the Prevention of Atherosclerosis Trial (EPAT) | Troglitazone Atherosclerosis Regression Trial (TART) | Vitamin E Atherosclerosis Prevention Study (VEAPS) | Women's Estrogen-Progestin Lipid-Lowering Hormone Atherosclerosis Regression Trial (WELL-HART) Consistent with cross-sectional findings and animal studies, this is the first study to report an association between exposure to air pollution and the progression of atherosclerosis - indicated with carotid artery intima-media thickness change - in humans. Air Pollutants Study subjects United States air Particulate Matter Details Atherosclerosis
2. Jones MR, et al. (2015). Multi-Ethnic Study of Atherosclerosis (MESA) The smaller carotid intima-media thickness levels in U.S. Chinese participants were even smaller after accounting for higher particulate matter (PM2.5) concentrations compared with Caucasian-Americans; however, air pollution was not related to intima-media thickness differences in African-Americans and Hispanics compared with Caucasian-Americans. race Air Pollutants Study subjects United States air, ambient Nitrogen Oxides | Particulate Matter Details Carotid Intimal Medial Thickness 1 | blood vessel development
3. Wittkopp S, et al. (2016). Cardiovascular Health and Air Pollution Study We report novel associations of gene expression changes with traffic-related air pollution exposures in a Los Angeles cohort of elderly subjects with coronary artery disease in this exploratory panel study analysis. Air Pollutants | Carbon | Carbon Monoxide | hopane | Nitrogen Dioxide | Nitrogen Oxides | Organic Chemicals | Ozone | Particulate Matter | Polycyclic Aromatic Hydrocarbons | Soot Subjects with disease:Coronary Artery Disease United States air | blood Carbon | Carbon Monoxide | CYP1B1 | HMOX1 | hopane | IL1B | NFE2L2 | Nitrogen Dioxide | Nitrogen Oxides | NQO1 | Organic Chemicals | Ozone | Particulate Matter | Polycyclic Aromatic Hydrocarbons | SELP | SOD2 | Soot Details gene expression
4. Brüske I, et al. (2011). Air Pollution and Inflammatory Response in Myocardial Infarction Survivors: Gene-Environment Interaction in a High Risk Group (AIRGENE) These preliminary findings should be replicated in other study populations because they suggest that the accumulation of acute and subacute effects or the chronic exposure to ambient particulate and gaseous air pollution may result in the promotion of atherosclerosis, mediated, at least in part, by increased levels of lipoprotein-associated phospholipase A2. Air Pollutants | Carbon Monoxide | Nitric Oxide | Nitrogen Dioxide | Ozone | Particulate Matter | Sulfur Dioxide Subjects with disease:Myocardial Infarction Germany air, ambient | plasma Carbon Monoxide | Nitric Oxide | Nitrogen Dioxide | Ozone | Particulate Matter | PLA2G7 | Sulfur Dioxide Details Atherosclerosis
5. Delfino RJ, et al. (2010). Traffic emission sources of organic chemicals represented by polycyclic aromatic hydrocarbons are associated with increased systemic inflammation and explain associations with quasi-ultrafine particle mass. Air Pollutants | hopane | Polycyclic Aromatic Hydrocarbons | Vehicle Emissions Subjects with disease:Coronary Artery Disease United States air, outdoor | plasma Alkanes | Chromium | Copper | hopane | IL6 | Iron | Manganese | Nickel | Particulate Matter | Polycyclic Aromatic Hydrocarbons | TNFRSF1B | Vanadium | Zinc Details
6. Ward-Caviness CK, et al. (2016). CATHeterization GENetics (CATHGEN) Our results reveal a novel gene (and possibly gene family) associated with peripheral arterial disease, via an interaction with traffic air pollution exposure; these results highlight the potential for interactions studies, particularly at the genome scale, to reveal novel biology linking environmental exposures to clinical outcomes. genetics Air Pollutants | Vehicle Emissions Subjects with gene influence:BMP2 | Subjects with gene influence:BMP8A United States Details Peripheral Arterial Disease
7. Wang CH, et al. (2010). QT dispersion may be indicated as an early biomarker for atherosclerotic diseases and a significant and strong predictor of cardiovascular mortality in populations with chronic arsenic exposure. Arsenic Study subjects Taiwan, Province of China Details Carotid Artery Diseases | Coronary Artery Disease | regulation of ventricular cardiac muscle cell membrane repolarization
8. Chen Y, et al. (2006). Health Effects of Arsenic Longitudinal Study (HEALS) Although the observed associations were not statistically significant, the trend of effect estimates suggests a possible role of low/moderate levels of arsenic exposure in progression of atherosclerosis, thus warranting the need for future investigation. Arsenic Study subjects Bangladesh urine | water, drinking Arsenic Details Atherosclerosis
9. D'Ippoliti D, et al. (2015). Results provide new evidence for risk assessment of low-medium concentrations of arsenic and contribute to the ongoing debate about the threshold-dose of effect, suggesting that even concentrations below 10 micrograms per liter carry a mortality risk. sex Arsenic Study subjects Italy Arsenic Details Death | Diabetes Mellitus | Lung Neoplasms | Myocardial Infarction | Peripheral Arterial Disease | Pulmonary Disease, Chronic Obstructive
10. Osorio-Yáñez C, et al. (2013). Arsenic exposure was positively associated with carotid intima-media thickness in a population of Mexican children with environmental arsenic exposure through drinking water. diet Arsenic Children Mexico plasma | urine | water, drinking Arsenicals | Arsenic | Cacodylic Acid | ICAM1 | monomethylarsonic acid | VCAM1 Details Carotid Intimal Medial Thickness 1 | blood vessel development
11. Wu F, et al. (2014). Health Effects of Arsenic Longitudinal Study (HEALS) We conducted a cross-sectional study to evaluate whether the association between arsenic exposure and carotid artery intima-media thickness differs by single nucleotide polymorphisms; the findings provide evidence that genetic variants related to arsenic metabolism may play an important role in arsenic-induced subclinical atherosclerosis. diet Arsenic Subjects with gene influence:APOE | Subjects with gene influence:AS3MT | Subjects with gene influence:PNP | Study subjects | Subjects with gene influence:TNF Bangladesh urine | water, well Arsenic Details Carotid Intimal Medial Thickness 1
12. Melzer D, et al. (2012). European Prospective Investigation into Cancer and Nutrition (EPIC) Study Associations between higher bisphenol A exposure (reflected in higher urinary concentrations) and incident coronary artery disease during >10 years of follow-up showed trends similar to previously reported cross-sectional findings in the more highly exposed NHANES respondents. bisphenol A Controls for disease:Coronary Artery Disease | Subjects with disease:Coronary Artery Disease United Kingdom urine bisphenol A Details Coronary Artery Disease
13. Shankar A, et al. (2012). National Health and Nutrition Examination Survey (NHANES) Urinary bisphenol A levels were significantly associated with peripheral arterial disease, independent of traditional cardiovascular disease risk factors. race | sex | tobacco bisphenol A Study subjects United States urine bisphenol A Details Peripheral Arterial Disease
14. Tellez-Plaza M, et al. (2010). National Health and Nutrition Examination Survey (NHANES) In this representative sample of the US population, high cadmium levels were associated with an increased prevalence of Peripheral Artery Disease (PAD), but the association between cadmium and PAD at low cadmium exposures was markedly different in men and women. sex Cadmium | Cotinine | Lead Controls for disease:Peripheral Arterial Disease | Subjects with disease:Peripheral Arterial Disease | Study subjects United States blood | serum | urine Cadmium | Cotinine | Lead Details Peripheral Arterial Disease
15. Asgary S, et al. (2017). The present results showed that serum levels of heavy metals are associated with the presence of coronary artery disease. Long-term exposure to trace levels of Lead, Cadmium and Mercury may play a role in the development of coronary atherosclerotic plaques. Cadmium | Lead | Mercury Controls for disease:Coronary Artery Disease | Subjects with disease:Coronary Artery Disease | Study subjects Iran, Islamic Republic of serum Cadmium | Lead | Mercury Details Coronary Artery Disease
16. Wittkopp S, et al. (2013). Our results suggest that, in a small cohort of elderly adults with coronary artery disease, mitochondrial haplogroup U may have lower susceptibility to adverse effects of traffic-related air pollution compared to haplogroup H. genetics Carbon | Carbon Monoxide | hopane | Nitrogen Oxides | Organic Chemicals | Ozone | Particulate Matter | Polycyclic Aromatic Hydrocarbons | Soot Subjects with disease:Coronary Artery Disease United States air Carbon | Carbon Monoxide | hopane | Nitrogen Oxides | Organic Chemicals | Ozone | Particulate Matter | Polycyclic Aromatic Hydrocarbons | Soot Details inflammatory response
17. Sun M, et al. (2013). Multi-Ethnic Study of Atherosclerosis (MESA) Employing commonly-used exposure estimation approaches, all of the Particulate Matter (2.5) components considered, except silicon, were associated with increased carotid intima-media thickness, with the evidence being strongest for organic carbon; no component was associated with increased coronary artery calcium. Carbon | Particulate Matter | Silicon | Soot | Sulfur Study subjects United States air Carbon | Particulate Matter | Silicon | Soot | Sulfur Details Atherosclerosis
18. Carreón T, et al. (2014). This study found evidence for excess hepatobiliary cancer mortality among workers exposed to vinyl chloride in a chemical manufacturing plant, as well as a trend with 20-year lagged duration of exposure. Carbon Disulfide | Vinyl Chloride Workers United States Details Coronary Artery Disease | Death | Liver Neoplasms
19. Koken PJ, et al. (2003). In summary, the results of this study in Denver suggest that ozone increases the risk of hospitalization for acute myocardial infarction, coronary atherosclerosis, and pulmonary heart disease. Sulfur dioxide appears to be related to increased hospital stays for cardiac dysrhythmias, and carbon monoxide is significantly associated with congestive heart failure hospitalization. sex Carbon Monoxide | Nitrogen Dioxide | Ozone | Particulate Matter | Sulfur Dioxide Study subjects United States air Carbon Monoxide | Nitrogen Dioxide | Ozone | Sulfur Dioxide Details Arrhythmias, Cardiac | Atherosclerosis | Heart Failure | Myocardial Infarction | Pulmonary Heart Disease
20. Li WF, et al. (2006). Our results suggest that the decrease in serum PON1 activity due to lead exposure may render individuals more susceptible to atherosclerosis, particularly subjects who are homozygous for the R192 allele. genetics Lead Subjects with gene influence:PON1 | Workers Taiwan, Province of China blood Lead | PON1 Details Atherosclerosis
21. Oudin A, et al. (2016). Betula Study We observed associations between dementia incidence and local traffic pollution that remained after adjusting for known risk factors. Nitrogen Oxides Study subjects Sweden Nitrogen Oxides Details Alzheimer Disease | Dementia, Vascular
22. Hoffmann B, et al. (2009). German Heinz Nixdorf Recall Study Our study indicates that long-term residential exposure to high levels of Particulate Matter (2.5) is associated with systemic inflammatory markers in men. sex Ozone | Particulate Matter Controls for disease:Coronary Disease | Subjects with disease:Coronary Disease | Controls for disease:Diabetes Mellitus | Subjects with disease:Diabetes Mellitus | Study subjects Germany air CRP | Ozone | Particulate Matter Details Atherosclerosis | Inflammation
23. Winquist A, et al. (2014). C8 Science Panel (C8SP) Higher perfluorooctanoic acid exposure was associated with incident hypercholesterolemia with medication, but not with hypertension or coronary artery disease. sex perfluorooctanoic acid Study subjects United States serum perfluorooctanoic acid Details Coronary Artery Disease | Hypercholesterolemia | Hypertension
1–23 of 23 results.