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Disease Mental Disorders

These are exposure studies associated with the disease and all of its children.

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1–50 of 94 results.
  Reference Associated Study Title Author's Summary Study Factors Stressor Receptors Country Medium Exposure Marker Measurements Outcome
1. Kalkbrenner AE, et al. (2018). Autism Genetic Resource Exchange (AGRE) Some air toxics were associated with autism spectrum disorder risk and severity, including some traffic-related air pollutants and newly-reported associations, but other previously reported associations with metals and volatile organic compounds were not reproducible. 1,4-dioxane | 4,4'-diphenylmethane diisocyanate | 4-dichlorobenzene | benzidine | bromoform | Carbon Disulfide | chlorobenzene | Dibenzofurans | methyl tert-butyl ether | propionaldehyde | Urethane Subjects with disease:Autism Spectrum Disorder United States Details Autism Spectrum Disorder
2. Hertz-Picciotto I, et al. (2011). Childhood Autism Risks from Genetics and the Environment (CHARGE) Children with autism/autism spectrum disorder and developmental delay were similar to typically developing controls for all polybrominated diphenyl ether congeners, but levels were high for all three groups. 2,2',3,3',4,4',5,6,6'-nonabromodiphenyl ether | 2,2',3,3',4,4',6,6'-octabromodiphenyl ether | 2,2',3,4,4',5',6-heptabromodiphenyl ether | 2,2',4,4',5-brominated diphenyl ether | 2,2',4,4'-tetrabromodiphenyl ether | decabromobiphenyl ether | hexabrominated diphenyl ether 153 | pentabrominated diphenyl ether 100 | pentabromodiphenyl ether | tribromodiphenyl ether 28 Subjects with disease:Autism Spectrum Disorder | Controls for disease:Developmental Disabilities | Subjects with disease:Developmental Disabilities United States serum 2,2',3,3',4,4',5,6,6'-nonabromodiphenyl ether | 2,2',3,3',4,4',6,6'-octabromodiphenyl ether | 2,2',3,4,4',5',6-heptabromodiphenyl ether | 2,2',4,4',5-brominated diphenyl ether | 2,2',4,4'-tetrabromodiphenyl ether | decabromobiphenyl ether | hexabrominated diphenyl ether 153 | pentabrominated diphenyl ether 100 | pentabromodiphenyl ether | tribromodiphenyl ether 28 Details
3. Forns J, et al. (2016). Norwegian Human Milk Study (HUMIS) Within a mixture of 24 toxicants measured in breast milk, p,p'-DDT was the single toxicant associated with behavioral problems at 12 months using different methods for handling numerous correlated exposures. 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',3',4,4',5-hexachlorobiphenyl | 2,2',4,4',5-brominated diphenyl ether | 2,2',4,4',5-pentachlorobiphenyl | 2,2',4,4'-tetrabromodiphenyl ether | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3,4,4'5-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,4',5-tetrachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | beta-hexachlorocyclohexane | DDT | Dichlorodiphenyl Dichloroethylene | hexabrominated diphenyl ether 153 | hexabromodiphenyl ether 154 | Hexachlorobenzene | oxychlordane | PCB 180 | pentabrominated diphenyl ether 100 | Polychlorinated Biphenyls | tribromodiphenyl ether 28 Infants or newborns | Mothers Norway milk, human 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',3',4,4',5-hexachlorobiphenyl | 2,2',4,4',5-brominated diphenyl ether | 2,2',4,4',5-pentachlorobiphenyl | 2,2',4,4'-tetrabromodiphenyl ether | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3,4,4'5-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,4',5-tetrachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | beta-hexachlorocyclohexane | DDT | Dichlorodiphenyl Dichloroethylene | hexabrominated diphenyl ether 153 | hexabromodiphenyl ether 154 | Hexachlorobenzene | oxychlordane | PCB 180 | pentabrominated diphenyl ether 100 | Polychlorinated Biphenyls | tribromodiphenyl ether 28 Details Child Behavior Disorders
4. Fitzgerald EF, et al. (2008). The results suggest that exposure to Polychlorinated biphenyls may be associated with some measures of memory and learning and depression among adults 55-74 years of age whose current body burdens are similar to those of the general population. age | sex 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | DDT | Dichlorodiphenyl Dichloroethylene | Lead | Mercury | PCB 180 | Polychlorinated Biphenyls Study subjects United States blood | serum 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | Lead | Mercury | PCB 180 | Polychlorinated Biphenyls Details Depressive Disorder | cognition
5. Braun JM, et al. (2014). Health Outcomes and Measures of the Environment (HOME) | National Health and Nutrition Examination Survey (NHANES) We used a semi-Bayesian hierarchical regression model to estimate associations between prenatal blood or urine concentrations of 52 suspected endocrine disrupting chemicals and autistic behaviors at 4 and 5 years of age in a prospective birth cohort of 175 mothers and their children. socioeconomic status | tobacco 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',4,4',5,5'-hexabrominated diphenyl ether | 2,2',4,4',5-brominated diphenyl ether | 2,2',4,4',5-pentachlorobiphenyl | 2,2',4,4'-tetrabromodiphenyl ether | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,3',4,4'-tetrachlorobiphenyl | 2,4,4',5-tetrachlorobiphenyl | 2,4,4'-trichlorobiphenyl | 2,4,5,2',4',5'-hexabromobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | 2,4,5,2',5'-pentachlorobiphenyl | beta-hexachlorocyclohexane | bisphenol A | DDT | Dichlorodiphenyl Dichloroethylene | Diethylhexyl Phthalate | Halogenated Diphenyl Ethers | Hexachlorobenzene | hexadecafluoro-nonanoic acid | mono(2-ethyl-5-hydroxyhexyl) phthalate | mono-(2-ethylhexyl)phthalate | mono-benzyl phthalate | monobutyl phthalate | monoethyl phthalate | mono-isobutyl phthalate | nonachlor | oxychlordane | pentabrominated diphenyl ether 100 | pentabromodiphenyl ether | perfluorohexanesulfonic acid | perfluorooctane sulfonic acid | perfluorooctanoic acid | phthalic acid | Polychlorinated Biphenyls Children | Pregnant females | Study subjects United States serum | urine 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',4,4',5,5'-hexabrominated diphenyl ether | 2,2',4,4',5-brominated diphenyl ether | 2,2',4,4',5-pentachlorobiphenyl | 2,2',4,4'-tetrabromodiphenyl ether | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3,3',4,4'-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,3',4,4'-tetrachlorobiphenyl | 2,4,4',5-tetrachlorobiphenyl | 2,4,4'-trichlorobiphenyl | 2,4,5,2',4',5'-hexabromobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | 2,4,5,2',5'-pentachlorobiphenyl | 2-ethyl-5-carboxypentyl phthalate | beta-hexachlorocyclohexane | bisphenol A | DDT | Dichlorodiphenyl Dichloroethylene | Halogenated Diphenyl Ethers | Hexachlorobenzene | hexadecafluoro-nonanoic acid | mono(2-ethyl-5-hydroxyhexyl) phthalate | mono-(2-ethylhexyl)phthalate | mono-benzyl phthalate | monobutyl phthalate | monoethyl phthalate | mono-isobutyl phthalate | nonachlor | oxychlordane | pentabrominated diphenyl ether 100 | pentabromodiphenyl ether | perfluorohexanesulfonic acid | perfluorooctane sulfonic acid | perfluorooctanoic acid | phthalic acid | Polychlorinated Biphenyls Details Autism Spectrum Disorder
6. Lyall K, et al. (2017). Early Markers for Autism (EMA) | Project Baby's Breath (PBB) The overall pattern of our results suggests increases in risk of autism spectrum disorder and intellectual disability without autism with prenatal exposure to higher levels of a number of organochlorine compounds, particularly polychlorinated biphenyl ethers. 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',4,4',5-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,4'-trichlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | Dichlorodiphenyl Dichloroethylene | nonachlor | PCB 180 | Polychlorinated Biphenyls Children | Pregnant females United States serum 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',4,4',5-pentachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,4'-trichlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | Dichlorodiphenyl Dichloroethylene | nonachlor | PCB 180 | Polychlorinated Biphenyls Details Autism Spectrum Disorder | Intellectual Disability | Prenatal Exposure Delayed Effects
7. Hoffman K, et al. (2012). Pregnancy Infection and Nutrition (PIN) Babies Study Our results suggest an association between early-life exposures to polybrominated diphenyl ethers via breast milk and increased externalizing behaviors in early childhood, particularly for activity/impulsivity behaviors. 2,2',4,4',5-brominated diphenyl ether | 2,2',4,4'-tetrabromodiphenyl ether | Halogenated Diphenyl Ethers | hexabrominated diphenyl ether 153 | pentabrominated diphenyl ether 100 | tribromodiphenyl ether 28 Infants or newborns United States milk, human 2,2',4,4',5-brominated diphenyl ether | 2,2',4,4'-tetrabromodiphenyl ether | hexabrominated diphenyl ether 153 | pentabrominated diphenyl ether 100 | tribromodiphenyl ether 28 Details Child Behavior Disorders
8. Beard JD, et al. (2014). Agricultural Health Study (AHS) Our study supports a positive association between pesticide exposure and depression, including associations with several specific pesticides. 2,4,5-Trichlorophenoxyacetic Acid | aluminum phosphide | Diazinon | Dieldrin | Ethylene Dibromide | Hydrocarbons, Chlorinated | Malathion | Parathion | Pesticides Workers United States Details Agricultural Workers' Diseases | Depressive Disorder
9. Beard JD, et al. (2013). Agricultural Health Study (AHS) Our study adds further evidence that high level pesticide exposure, such as pesticide poisoning, is associated with increased risk of depression and sets a lower bound on the level of exposure related to depression, thereby providing reassurance that the moderate levels of pesticide exposure experienced by farmers' wives likely do not increase risk. age | tobacco 2-chloro-N-(ethoxymethyl)-N-(2-methyl-6-(trifluoromethyl)phenyl)acetamide | Carbamates | Herbicides | metalaxyl | Permethrin | Pesticides | Triazines Study subjects United States Details Agricultural Workers' Diseases | Depressive Disorder
10. Lyall K, et al. (2018). Early Markers for Autism (EMA) Results from this large case-control study with prospectively collected prenatal measurements do not support the hypothesis that prenatal exposure to per- and polyfluoroalkyl substances is positively associated with autism spectrum disorder or intellectual disability. 2-(N-methylperfluorooctanesulfonamido)acetic acid | hexadecafluoro-nonanoic acid | N-ethyl perfluorooctane sulfonamido acetate | perfluorodecanoic acid | perfluorohexanesulfonic acid | perfluorooctanesulfonamide | perfluorooctane sulfonic acid | perfluorooctanoic acid Subjects with disease:Autism Spectrum Disorder | Children | Subjects with disease:Intellectual Disability | Pregnant females United States serum 2-(N-methylperfluorooctanesulfonamido)acetic acid | hexadecafluoro-nonanoic acid | N-ethyl perfluorooctane sulfonamido acetate | perfluorodecanoic acid | perfluorohexanesulfonic acid | perfluorooctanesulfonamide | perfluorooctane sulfonic acid | perfluorooctanoic acid Details Autism Spectrum Disorder | Intellectual Disability
11. Fortenberry GZ, et al. (2014). Early Life Exposure in Mexico to Environmental Toxicants (ELEMENT) | National Health and Nutrition Examination Survey (NHANES) The objective of this study was to investigate the relationship between in utero exposure to chlorpyrifos, chlorpyrifos-methyl, and/or 3,5,6-trichloro-2-pyridinol (TCPY) and ADHD in school-age Mexican children using TCPY as a biomarker of exposure. sex 3,5,6-trichloro-2-pyridinol | Chlorpyrifos | chlorpyrifos-methyl | Lead Children | Pregnant females Mexico blood | urine 3,5,6-trichloro-2-pyridinol | Lead Details Attention Deficit Disorder with Hyperactivity | behavior | cognition
12. Yu CJ, et al. (2016). This case-control study found that 4-nonylphenol exposure was not a risk factor for Attention Deficit Disorder with Hyperactivity in school-age children in Taiwan after adjusting for confounding factors. 4-nonylphenol | Lead Controls for disease:Attention Deficit Disorder with Hyperactivity | Subjects with disease:Attention Deficit Disorder with Hyperactivity | Children Taiwan, Province of China blood | urine 4-nonylphenol | Lead Details Attention Deficit Disorder with Hyperactivity
13. Kalkbrenner AE, et al. (2010). Autism and Developmental Disabilities Monitoring Network (ADDM) Our screening design was limited by exposure misclassification of air pollutants and the use of an alternate developmental disorder as the control group, both of which may have biased results toward the null. Despite these limitations, methylene chloride, quinoline, and styrene emerged (based on this analysis and prior epidemiologic evidence) as candidates that warrant further investigation for a possible role in autism etiology. Air Pollutants United States air 1,1,2,2-tetrachloroethane | 1,3-butadiene | 1,3-dichloro-1-propene | Acetaldehyde | Acrolein | Acrylonitrile | Arsenicals | Benzene | Beryllium | Cadmium Compounds | Carbon Tetrachloride | Chloroform | Chromium Compounds | Coke | ethylbenzene | Ethylene Dibromide | ethylene dichloride | Ethylene Oxide | Formaldehyde | Hexachlorobenzene | Hexanes | hydrazine | Lead | Manganese Compounds | Mercury Compounds | Methylene Chloride | methyl tert-butyl ether | Nickel | Polychlorinated Biphenyls | Polycyclic Aromatic Hydrocarbons | propionaldehyde | propylene dichloride | quinoline | Styrene | Tetrachloroethylene | Toluene | Trichloroethylene | Vehicle Emissions | Vinyl Chloride | Xylenes Details Autism Spectrum Disorder
14. Chen G, et al. (2018). Exposures to air pollutant particulate matter (PM1, PM2.5 and PM10) during the first three years of life were associated with the increased risk of autism spectrum disorder and there appeared to be stronger effects of ambient pollution in the second and the third years after birth. age Air Pollutants Controls for disease:Autism Spectrum Disorder | Subjects with disease:Autism Spectrum Disorder | Children China air, ambient Particulate Matter Details Autism Spectrum Disorder
15. Volk HE, et al. (2011). Childhood Autism Risks from Genetics and the Environment (CHARGE) Autism was also associated with residential proximity to a freeway during the third trimester. Air Pollutants Study subjects United States Details Autistic Disorder
16. Windham GC, et al. (2006). Our results suggest a potential association between autism and estimated metal concentrations, and possibly chlorinated solvents, in ambient air around the birth residence, requiring confirmation and more refined exposure assessment in future studies. Air Pollutants Controls for disease:Autism Spectrum Disorder | Subjects with disease:Autism Spectrum Disorder | Children United States air, ambient Arsenic | Benzene | Cadmium | Chromium | ethylbenzene | hydrazine | Hydrocarbons, Chlorinated | Lead | Manganese | Mercury | Metals, Heavy | Methylene Chloride | Nickel | Particulate Matter | Polycyclic Aromatic Hydrocarbons | Solvents | Styrene | Tetrachloroethylene | Toluene | Trichloroethylene | Vinyl Chloride | Xylenes Details Autism Spectrum Disorder
17. Newman NC, et al. (2013). Cincinnati Childhood Allergy and Air Pollution Study (CCAAPS) Elemental carbon attributed to traffic exposure during infancy was associated with higher Hyperactivity scores in children; this association was limited to children whose mothers had more than a high school education. Air Pollutants | Carbon | Particulate Matter Children United States Particulate Matter Details Attention Deficit Disorder with Hyperactivity | Conduct Disorder
18. Chiu YH, et al. (2016). Asthma Coalition on Community, Environment, and Social Stress (ACCESS) Increased particulate matter PM2.5 exposure in specific prenatal windows may be associated with poorer function across memory and attention domains with variable associations based on sex. sex Air Pollutants | Vehicle Emissions Children | Fetuses | Pregnant females United States air, ambient Particulate Matter Details Neurodevelopmental Disorders | Prenatal Exposure Delayed Effects | learning or memory | memory
19. Nevison CD. (2014). Temporal trends in autism were constructed both by tracking prevalence at a constant age in a series of historical IDEA reports and by computing prevalence from age-resolved snapshots in individual, recent IDEA reports. Aluminum | glyphosate | Halogenated Diphenyl Ethers | Hydrocarbons, Chlorinated | Lead | Vehicle Emissions Children United States Details Autism Spectrum Disorder
20. Rondeau V, et al. (2009). Aluminum Maladie d'Alzheimer (ALMA+) | Personnes Agees Quid Study (PAQUID) We found that the cognitive decline and the risk of dementia were higher for high consumption of Aluminum from drinking water. age Aluminum | Silicon Dioxide Study subjects France water, drinking, bottled | water, tap Aluminum | Silicon Dioxide Details Alzheimer Disease | cognition
21. Solfrizzi V, et al. (2013). Italian Longitudinal Study on Aging (ILSA) Using a large, population-based cohort, we investigated whether angiotensin-converting enzyme inhibitors collectively as a 'class' and as sub-groups according to their chemical structures and drug potencies, compared with other antihypertensive agents and beyond the natural course in time of the hypertension, reduced the incidence of mild cognitive impairment in cognitively normal individuals. Angiotensin-Converting Enzyme Inhibitors | Enalapril | Lisinopril Subjects with disease:Hypertension Italy Details Cognitive Dysfunction
22. Hsieh FI, et al. (2008). Results suggested that chronic arsenic exposure has a negative impact on erectile function. age Arsenic Study subjects Taiwan, Province of China Details Erectile Dysfunction | regulation of hormone metabolic process
23. Zierold KM, et al. (2004). Respondents with arsenic levels of 2 microg/L or greater were statistically more likely to report a history of depression, high blood pressure, circulatory problems, and bypass surgery than were respondents with arsenic concentrations less than 2 microg/L. Arsenic Study subjects United States water Arsenic Details Depressive Disorder | Heart Diseases | Hypertension
24. Nyanza EC, et al. (2014). Pregnant women who eat soil (pica, a common cultural practice in Tanzania) are exposed to potentially high levels of chemical elements, depending upon frequency of consumption, daily amount consumed, and the source location of soil eaten. diet Arsenic | Cadmium | Chromium | Copper | Manganese | Mercury | Soil | Zinc Subjects with disease:Pica | Pregnant females | Study subjects Tanzania, United Republic of|United States soil Arsenic | Cadmium | Chromium | Copper | Iron | Lead | Manganese | Mercury | Nickel | Zinc Details
25. Wasserman GA, et al. (2007). Exposure to arsenic from drinking water was associated with reduced intellectual function before and after adjusting for water manganese for blood lead levels, and for sociodemographic features. diet Arsenic | Lead | Manganese Children Bangladesh blood | urine | water, drinking Arsenic | Lead | Manganese Details Arsenic Poisoning | Learning Disorders
26. Rodrigues EG, et al. (2016). Where blood lead levels are high, lead is associated with decreased cognitive scores (and effects of other metals are not detected); however, in the setting of lower lead levels, the adverse effects of arsenic and manganese on neurodevelopment are observed. age | diet Arsenic | Lead | Manganese Children | Infants or newborns | Pregnant females Bangladesh blood | water, well Arsenic | Lead | Manganese Details Motor Skills Disorders | Neurodevelopmental Disorders | cognition | motor behavior
27. Rahman SM, et al. (2016). Maternal and Infant Nutrition Interventions in Matlab (MINIMat) Elevated prenatal water manganese exposure was positively associated with cognitive function in girls, while boys appeared unaffected; however, early-life exposure appeared to adversely affect children's behavior. age | diet | sex Arsenic | Manganese Children | Pregnant females Bangladesh water, drinking Arsenic | Manganese Details Child Behavior Disorders | cognition
28. Clemente M, et al. (2015). Participants affected by asbestos poisoning showed high occurrence rates of psychological health variables such as somatization, obsessive-compulsive, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, psychoticism, and global severity index. Asbestos Workers Spain Details Anxiety Disorders | Depressive Disorder | Obsessive-Compulsive Disorder | Paranoid Disorders | Phobic Disorders | Psychotic Disorders | Somatoform Disorders
29. Evans SF, et al. (2014). Study for Future Families (SFF) We report an association between maternal urinary bisphenol A concentrations during pregnancy and sexually dimorphic behaviors in school age children. sex bisphenol A Children | Fetuses | Pregnant females United States urine bisphenol A Details Anxiety Disorders | Attention Deficit and Disruptive Behavior Disorders | Conduct Disorder | aggressive behavior | behavior
30. Li DK, et al. (2010). Our results reveal a correlation between a biological measure of urine bisphenol A level and declining male sexual function. bisphenol A Workers China urine bisphenol A Details Erectile Dysfunction | penile erection
31. Ciesielski T, et al. (2012). National Health and Nutrition Examination Survey (NHANES) These findings suggest that children who have higher urinary cadmium concentrations may have increased risk of both learning disability and special education. Importantly, we observed these associations at exposure levels that were previously considered to be without adverse effects, and these levels are common among U.S. children. race | socioeconomic status Cadmium Children United States urine Cadmium Details Attention Deficit Disorder with Hyperactivity | Learning Disorders
32. Min JY, et al. (2016). National Health and Nutrition Examination Survey (NHANES) We observed a significant association between blood cadmium levels and Alzheimer disease mortality among older adults in the US. age Cadmium Controls for disease:Diabetes Mellitus | Subjects with disease:Diabetes Mellitus | Controls for disease:Hypertension | Subjects with disease:Hypertension | Study subjects United States blood Cadmium Details Alzheimer Disease
33. Szkup-Jabłońska M, et al. (2012). The effect of lead on the developing child has behavioral consequences including attention disorders, hyperactivity, and impulsive behavior; no effect of cadmium was shown. age Cadmium | Lead Subjects with disease:Attention Deficit Disorder with Hyperactivity | Subjects with disease:Child Behavior Disorders | Children Poland blood Cadmium | Lead Details Attention Deficit Disorder with Hyperactivity
34. Przybyla J, et al. (2017). National Health and Nutrition Examination Survey (NHANES) This cross-sectional analysis which controlled for collinear exposure to several neurotoxic compounds demonstrated an association between non-dioxin like polychlorinated biphenyl exposure and lower cognitive functionion in older adults, and lead exposure was also weakly associated with lower cognitive functioning. age Cadmium | Lead | Polychlorinated Biphenyls Study subjects United States serum 2,2',3,3',4,4',5-heptachlorobiphenyl | 2,2',3',4,4',5-hexachlorobiphenyl | 2,2',3,4',5,5',6-heptachlorobiphenyl | 2,2',4,4',5-pentachlorobiphenyl | 2,3,3',4,4',5-hexachlorobiphenyl | 2,3',4,4',5-pentachlorobiphenyl | 2,4,4',5-tetrachlorobiphenyl | 2,4,5,2',4',5'-hexachlorobiphenyl | 3,4,5,3',4'-pentachlorobiphenyl | Cadmium | Lead | PCB 180 Details Cognitive Dysfunction | cognition
35. Scinicariello F, et al. (2015). National Health and Nutrition Examination Survey (NHANES) This is the first study reporting an association of blood cadmium levels with depressive symptoms using a nationally representative sample. tobacco Cadmium | Lead | Tobacco Smoke Pollution Study subjects United States blood Cadmium | Lead Details Depressive Disorder
36. Beseler C, et al. (2006). Agricultural Health Study (AHS) In this study, a history of pesticide poisoning was significantly associated with self-reported physician diagnosed depression among female spouses of private pesticide applicators, after controlling for other risk factors. age | alcohol drinking | race | tobacco Carbamates | Fungicides, Industrial | Herbicides | Insecticides | Pesticides Study subjects United States Details Agricultural Workers' Diseases | Depressive Disorder
37. Forns J, et al. (2016). BRain dEvelopment and Air polluTion ultrafine particles in scHool childrEn (BREATHE) Project In our study population of 7- to 11-year-old children residing in Barcelona, exposure to TRAPs at school was associated with increased behavioral problems in schoolchildren. Carbon | Nitrogen Dioxide | Soot Children Spain air Carbon | Nitrogen Dioxide | Soot Details Child Behavior Disorders
38. Sagiv SK, et al. (2018). Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) These findings contribute mixed evidence linking organophosphate pesticide exposures with traits related to developmental disorders like autism spectrum disorders. Chlorpyrifos | Diazinon | diethyl phosphate | dimethyl phosphate | Malathion | methyl demeton | Organophosphates | Pesticides Children | Pregnant females United States urine Chlorpyrifos | Diazinon | diethyl phosphate | dimethyl phosphate | Malathion | methyl demeton | Organophosphates | Pesticides Details Autism Spectrum Disorder
39. van Wendel de Joode B, et al. (2016). Our findings indicate that children living near banana and plantain plantations are exposed to pesticides that may affect their neurodevelopment, which for certain domains may differ between boys and girls. sex Chlorpyrifos | mancozeb | Pyrethrins Children Costa Rica urine 3,5,6-trichloro-2-pyridinol | 3-phenoxybenzoic acid | Ethylenethiourea Details Attention Deficit Disorder with Hyperactivity | behavior | cognition | learned vocalization behavior or vocal learning | memory | visual perception
40. Marks AR, et al. (2010). Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) In utero dialkyl phosphates (DAPs) and, to a lesser extent, postnatal DAPs were associated adversely with attention as assessed by maternal report, psychometrician observation, and direct assessment. These associations were somewhat stronger at 5 years than at 3.5 years and were stronger in boys. age | sex diethyl phosphate | dimethyl phosphate | Organophosphates Children | Mothers United States urine diethyl phosphate | dimethyl phosphate | Organophosphates Details Attention Deficit Disorder with Hyperactivity
41. Philippat C, et al. (2015). Childhood Autism Risks from Genetics and the Environment (CHARGE) House dust levels of phthalates were not associated with autism spectrum disorder (but limited interpretation); however, associations were observed for diethyl phthalate and dibutyl phthalate with impairments in several adaptive functions and greater hyperactivity, along with evidence for increased risk of developmental delay. Dust Subjects with disease:Autism Spectrum Disorder | Children | Subjects with disease:Developmental Disabilities United States dust, carpet butylbenzyl phthalate | Dibutyl Phthalate | Diethylhexyl Phthalate | diethyl phthalate | dimethyl phthalate Details Autism Spectrum Disorder | Developmental Disabilities | Hyperkinesis | psychomotor behavior
42. Blaurock-Busch E, et al. (2011). We assessed a spectrum of trace elements and heavy metals in hair and urine of both autistic and control groups to focus on the participants' past and present exposure. Elements | Metals Controls for disease:Autism Spectrum Disorder | Subjects with disease:Autism Spectrum Disorder | Children Saudi Arabia hair | urine Aluminum | Antimony | Arsenic | Barium | Beryllium | Bismuth | Boron | Cadmium | Calcium | Cerium | Cesium | Chromium | Cobalt | Copper | Gallium | Germanium | Iodine | Iron | Lead | Lithium | Magnesium | Manganese | Mercury | Molybdenum | Nickel | Palladium | Platinum | Selenium | Silver | Strontium | Thallium | Tin | Titanium | Tungsten | Uranium | Vanadium | Zinc | Zirconium Details
43. Sayal K, et al. (2014). Avon Longitudinal Study of Parents and Children (ALSPAC) The objective of the study is to investigate whether episodic binge pattern of alcohol consumption during pregnancy is independently associated with child mental health and academic outcomes. Ethanol Children United Kingdom Details Attention Deficit Disorder with Hyperactivity | Prenatal Exposure Delayed Effects | cognition
44. Ton TG, et al. (2010). In this population-based study in which all subjects had HLA DQB1*0602, we found a nearly five-fold increase in narcolepsy risk associated with jobs containing heavy metals and with six or more applications of bug or weed killer. genetics Fertilizers | Metals, Heavy | Pesticides Subjects with gene influence:HLA-DQB1 | Workers United States Details Narcolepsy
45. Herbstman JB, et al. (2010). This epidemiologic study demonstrates neurodevelopmental effects in relation to cord blood polybrominated diphenyl ether concentrations. Halogenated Diphenyl Ethers Infants or newborns United States blood, cord 2,2',3,4,4',5',6-heptabromodiphenyl ether | 2,2',4,4',5-brominated diphenyl ether | 2,2',4,4'-tetrabromodiphenyl ether | hexabrominated diphenyl ether 153 | hexabromodiphenyl ether 154 | PBB 153 | pentabrominated diphenyl ether 100 | pentabromodiphenyl ether Details Intellectual Disability | Psychomotor Disorders | cognition
46. Rahbar MH, et al. (2015). Jamaican Autism Study In univariable general linear models, we found a significant difference between geometric mean blood lead concentrations of autism spectrum disorder cases and controls; however, after controlling for potential confounders, there were no significant differences, and our results do not support an association between blood lead and autism spectrum disorder in Jamaican children. Lead Controls for disease:Autism Spectrum Disorder | Subjects with disease:Autism Spectrum Disorder | Children Jamaica blood Lead Details Autism Spectrum Disorder
47. Rajan P, et al. (2007). Normative Aging Study (NAS) We observed a deleterious association between current and cumulative lead burden and risk of psychiatric symptoms. At a given cumulative lead burden, participants with the ALAD 1-1 genotype appeared to be at greater risk than participants who were carriers of at least one variant ALAD allele. genetics Lead Subjects with gene influence:ALAD | Veterans United States blood | bone | patella | tibia Lead Details Lead Poisoning, Nervous System | Mental Disorders
48. Eum KD, et al. (2012). These results provide support for an association of low-level cumulative lead exposure with increased depressive and phobic anxiety symptoms among older women who are premenopausal or who consistently take postmenopausal hormone replacement therapy. age | disease Lead Workers United States patella | tibia Lead Details Anxiety Disorders | Depressive Disorder
49. Roy A, et al. (2009). Overall, this study suggests that lead exposure affects behavior across multiple domains, including anxiety and social behavior. The results also suggest that executive functions and attention are especially vulnerable to insult by lead among young children. Lead Children India blood Lead Details Anxiety Disorders | Attention Deficit Disorder with Hyperactivity | behavior | cognition
50. Golub NI, et al. (2010). National Health and Nutrition Examination Survey (NHANES) This cross-sectional study did not provide consistent evidence for an association between environmental lead exposure and depression within the investigated blood lead levels. Lead Controls for disease:Depressive Disorder | Subjects with disease:Depressive Disorder | Study subjects United States blood Lead Details Depressive Disorder
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