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Disease Brain Diseases

These are exposure studies associated with the disease and all of its children.

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1–50 of 62 results.
  Reference Associated Study Title Author's Summary Study Factors Stressor Receptors Country Medium Exposure Marker Measurements Outcome
1. Mi T, et al. (2013). We describe two cases of acute toxic leukoencephalopathy in migrant workers who were occupationally exposed to organic solvents in construction materials. 1,2,3-trichloropropane | Solvents | Toluene Workers China blood | urine 1,2,3-trichloropropane | Benzoic Acid Details Leukoencephalopathies | Neurotoxicity Syndromes | Occupational Diseases
2. Kamel F, et al. (2007). Agricultural Health Study (AHS) This study suggests that exposure to certain pesticides may increase Parkinson's disease risk. 2,4,5-Trichlorophenoxyacetic Acid | Benomyl | butylate | Carbon Disulfide | Carbon Tetrachloride | cyanazine | Dicamba | Ethylene Dibromide | Hexachlorocyclohexane | mancozeb | Maneb | methyl bromide | Paraquat | pendimethalin | Pesticides | Phorate | tetrachloroisophthalonitrile Study subjects | Workers United States Details Agricultural Workers' Diseases | Parkinson Disease
3. Andersen ZJ, et al. (2012). Danish Diet, Cancer, and Health Study (DCH) Long-term exposure to traffic-related air pollution may contribute to the development of ischemic but not hemorrhagic stroke, especially severe ischemic strokes leading to death within 30 days. Air Pollutants Study subjects Denmark Nitrogen Dioxide Details Brain Ischemia | Cerebral Hemorrhage | Stroke
4. Lin H, et al. (2017). Hourly peak concentration may capture health effects of ambient fine particulate matter pollution (PM2.5) better than daily averages; significant associations were found between hourly peak PM2.5 concentrations and cardiovascular mortality, particularly from ischemic heart diseases and cerebrovascular diseases. Air Pollutants Study subjects China air, ambient Nitrogen Dioxide | Ozone | Particulate Matter | Sulfur Dioxide Details Cardiovascular Diseases | Cerebrovascular Disorders | Death | Myocardial Ischemia
5. Liu R, et al. (2016). Parkinson's Genes and Environment Study (PAGE) Overall, we found limited evidence for an association between exposures to ambient particulate matter PM10, PM2.5, or nitrogen dioxide and Parkinson disease risk; however, the suggestive evidence that exposures to PM2.5 and PM10 may increase disease risk among female never-smokers warrants further investigation. sex | tobacco Air Pollutants Controls for disease:Parkinson Disease | Subjects with disease:Parkinson Disease United States air, ambient Nitrogen Dioxide | Particulate Matter Details Parkinson Disease
6. Zhang P, et al. (2011). Long-term exposure to ambient air pollution is associated with the death of cardiovascular and cerebrovascular diseases among Chinese populations. The effects of air pollution were more evident in female that in male, and nonsmokers and residents with body mass index less than 18.5 were more vulnerable to outdoor air pollution. body mass index | sex | tobacco Air Pollutants Study subjects China air, ambient Nitrogen Dioxide | Particulate Matter | Sulfur Dioxide Details Cardiovascular Diseases | Cerebrovascular Disorders | Death
7. Raaschou-Nielsen O, et al. (2011). Diet, Cancer and Health Study This hypothesis-generating study indicates that traffic-related air pollution might increase the risks for cervical and brain cancer, which should be tested in future studies. Air Pollutants | Vehicle Emissions Study subjects Denmark air Nitrogen Oxides Details Brain Neoplasms | Uterine Cervical Neoplasms
8. Kamel F, et al. (2014). Agricultural Health Study (AHS) | Farming and Movement Evaluation Study (FAME) Polyunsaturated fatty acid intake was consistently associated with lower Parkinson's disease (PD) risk, and dietary fats modified the association of PD risk with pesticide exposure. alpha-Linolenic Acid | Fatty Acids | Fatty Acids, Unsaturated | Paraquat | Rotenone Controls for disease:Parkinson Disease | Subjects with disease:Parkinson Disease | Workers United States Details Agricultural Workers' Diseases | Parkinson Disease
9. Rondeau V, et al. (2009). Aluminum Maladie d'Alzheimer (ALMA+) | Personnes Agees Quid Study (PAQUID) We found that the cognitive decline and the risk of dementia were higher for high consumption of Aluminum from drinking water. age Aluminum | Silicon Dioxide Study subjects France water, drinking, bottled | water, tap Aluminum | Silicon Dioxide Details Alzheimer Disease | cognition
10. Wang CH, et al. (2002). Carotid atherosclerosis is associated with ingested inorganic arsenic, showing a significant biological gradient. Arsenic Study subjects Taiwan, Province of China Arsenic Details Carotid Artery Diseases
11. Rahman M, et al. (2014). The result suggests that arsenic exposure from drinking water was associated with increased stroke mortality risk and was more significant in women compared to men. diet | sex Arsenic Controls for disease:Death | Subjects with disease:Death | Controls for disease:Stroke | Subjects with disease:Stroke | Study subjects Bangladesh water, well Arsenic Details Death | Stroke
12. Wang CH, et al. (2010). QT dispersion may be indicated as an early biomarker for atherosclerotic diseases and a significant and strong predictor of cardiovascular mortality in populations with chronic arsenic exposure. Arsenic Study subjects Taiwan, Province of China Details Carotid Artery Diseases | Coronary Artery Disease | regulation of ventricular cardiac muscle cell membrane repolarization
13. Moon KA, et al. (2013). Strong Heart Study (SHS) Low to moderate chronic arsenic exposure, as measured in urine, was prospectively associated with cardiovascular disease incidence and mortality. Arsenic Study subjects United States urine Arsenic Details Cardiovascular Diseases | Coronary Disease | Death | Stroke
14. Chen Y, et al. (2013). Health Effects of Arsenic Longitudinal Study (HEALS) Arsenic exposure from drinking water and the incomplete methylation capacity of arsenic were adversely associated with heart disease risk. age Arsenic | Cacodylic Acid | monomethylarsonic acid Subjects with disease:Cardiovascular Diseases | Subjects with disease:Heart Diseases | Subjects with disease:Stroke | Study subjects Bangladesh urine | water, well Arsenic | Cacodylic Acid | monomethylarsonic acid Details Cardiovascular Diseases | Heart Diseases | Stroke
15. Thorpe N, et al. (2005). This hypothesis-generating study explores spatial patterns of childhood cancers in Maryland and investigates their potential associations with herbicides and nitrates in groundwater. Atrazine | metolachlor | Nitrates Children United States Details Bone Neoplasms | Brain Neoplasms | Leukemia | Lymphoma
16. Hecht EM, et al. (2016). National Health and Nutrition Examination Survey (NHANES) These descriptive data from a nationally representative sample suggest that cadmium is related to cardiovascular outcomes even after adjustment for smoking status. Cadmium Study subjects United States blood | urine Cadmium Details Myocardial Infarction | Stroke
17. Min JY, et al. (2016). National Health and Nutrition Examination Survey (NHANES) We observed a significant association between blood cadmium levels and Alzheimer disease mortality among older adults in the US. age Cadmium Controls for disease:Diabetes Mellitus | Subjects with disease:Diabetes Mellitus | Controls for disease:Hypertension | Subjects with disease:Hypertension | Study subjects United States blood Cadmium Details Alzheimer Disease
18. Peters JL, et al. (2010). National Health and Nutrition Examination Survey (NHANES) Environmental exposure to cadmium was associated with significantly increased stroke and heart failure prevalence. sex | tobacco Cadmium Study subjects United States blood | urine Cadmium Details Heart Failure | Stroke
19. Barregard L, et al. (2016). Malmo Diet and Cancer Study Blood cadmium in the highest quartile was associated with incident cardiovascular disease and mortality in our population-based samples of Swedish adults. tobacco Cadmium Study subjects Sweden blood Cadmium Details Cardiovascular Diseases | Myocardial Ischemia | Stroke
20. Ferrandiz J, et al. (2004). We used exposure analysis to assess the effect of both protective factors-calcium and magnesium-on mortality from cerebrovascular (ICD-9 430-438) and ischemic heart (ICD-9 410-414) diseases. This study provides statistical evidence of the relationship between mortality from cardiovascular diseases and hardness of drinking water. Calcium | Magnesium Study subjects Spain Details Cardiovascular Diseases | Cerebrovascular Disorders | Death
21. Ritz B, et al. (2016). We found ambient air pollution from traffic sources to be associated with risk of Parkinson's Disease, with a 9% higher risk (95% CI: 3, 16.0%) per interquartile range increase (2.97 micrograms per cubic meter) in modeled nitrogen dioxide. Carbon Monoxide | Nitric Oxide | Nitrogen Dioxide Study subjects Denmark Carbon Monoxide | Nitric Oxide | Nitrogen Dioxide Details Parkinson Disease
22. Milojevic A, et al. (2014). This study found no clear evidence for pollution effects on ST-elevation myocardial infarctions and stroke, which ultimately represent thrombogenic processes, though it did for pulmonary embolism. age | sex Carbon Monoxide | Nitrogen Dioxide | Ozone | Particulate Matter | Sulfur Dioxide Study subjects United Kingdom air, ambient Carbon Monoxide | Nitrogen Dioxide | Ozone | Particulate Matter | Sulfur Dioxide Details Arrhythmias, Cardiac | Atrial Fibrillation | Cardiovascular Diseases | Death | Stroke
23. Narayan S, et al. (2013). We provide evidence that household use of organophosphorus chemical pesticides is associated with an increased risk of developing Parkinson's disease. genetics Chlorpyrifos | Diazinon | Organophosphates | Organophosphorus Compounds | Organothiophosphates | Pesticides Subjects with gene influence:PON1 | Study subjects United States Details Parkinson Disease
24. Manthripragada AD, et al. (2010). Parkinson's Environment and Genes Study (PEG) The increase in risk we observed among PON1-55 variant carriers for specific organophosphates metabolized by PON1 underscores the importance of considering susceptibility factors when studying environmental exposures in Parkinson disease. genetics Chlorpyrifos | Diazinon | Pesticides Subjects with gene influence:PON1 United States Chlorpyrifos | Diazinon | Pesticides Details Parkinson Disease
25. Shcherbatykh I, et al. (2005). These results suggest that living near a source of persistent organic pollutants contamination constitutes a risk of exposure and an increased risk of acquiring cerebrovascular disease. age | race | sex Dioxins | Pesticides | Polychlorinated Biphenyls Study subjects United States Details Cerebral Infarction
26. Feldman AL, et al. (2011). Inorganic dust should be explored further as a potential risk factor for Parkinson's disease. tobacco Dust Workers Sweden Details Parkinson Disease | Parkinsonian Disorders
27. Narayan S, et al. (2015). This study lends support to a previous report that commonly used pesticides, specifically organochlorines and organophosphorous compounds, and variant ABCB1 genotypes at two polymorphic sites jointly increase risk of Parkinson's Disease. genetics Hydrocarbons, Chlorinated | Organophosphorus Compounds | Pesticides Subjects with gene influence:ABCB1 | Workers United States Details Parkinson Disease
28. Searles Nielsen S, et al. (2010). West Coast Childhood Brain Tumor Study Based on known effects of these variants, these results suggest that exposure in childhood to organophosphorus and perhaps to carbamate insecticides in combination with a reduced ability to detoxify them may be associated with childhood brain tumors. age Insecticides Subjects with gene influence:BCHE | Subjects with gene influence:FMO1 | Subjects with gene influence:PON1 United States Details Brain Neoplasms
29. Liao LM, et al. (2016). Shanghai Men's Health Study (SMHS) | Shanghai Women's Health Study (SWHS) In conclusion, our findings, though limited by small numbers of cases, suggest that lead exposure is associated with an increased risk of several cancers, in particular, meningioma, brain cancer, and kidney cancer. Lead Study subjects China Lead Details Brain Neoplasms | Kidney Neoplasms | Lung Neoplasms | Meningioma | Stomach Neoplasms
30. Weisskopf MG, et al. (2010). Normative Aging Study (NAS) These findings, using an objective biological marker of cumulative lead exposure among typical Parkinson Disease (PD) patients seen in our movement disorders clinics, strengthen the evidence that cumulative exposure to lead increases the risk of PD. Lead Study subjects United States patella | tibia Lead Details Parkinson Disease
31. Ritz BR, et al. (2009). Our population-based case-control study of Parkinson's Disease (PD) conducted in a California population heavily exposed to pesticides replicates and extends evidence for an association between dopamine transporter (DAT) variants and PD and highlights possible interactions of disease-associated DAT susceptibility alleles and pesticide exposure. genetics Maneb | Paraquat Subjects with gene influence:SLC6A3 | Workers United States Details Parkinson Disease
32. Costello S, et al. (2009). This study provides evidence that exposure to a combination of maneb and paraquat increases Parkinson's Disease risk, particularly in younger subjects and/or when exposure occurs at younger ages. age Maneb | Paraquat Study subjects United States Details Parkinson Disease
33. Searles Nielsen S, et al. (2015). Midwestern US Welders Cohort We assessed DNA methylation at three CpG sites in NOS2 gene exon 1 from the blood of 201 welders (exposed to manganese in fumes), and found parkinsonism cases had lower mean NOS2 methylation (specifically at site 8329 in an exonic splicing enhancer). Manganese Workers United States blood NOS2 Details Parkinson Disease, Secondary
34. Szabo ST, et al. (2016). We examined the relationship between metal levels in brain tissue and ventricular fluid from postmortem samples of Alzheimer disease cases and controls; we confirmed previous work suggesting an increase in iron in Alzheimer brain tissue and identified arsenic as a metal of interest for further evaluation. Metals Controls for disease:Alzheimer Disease | Subjects with disease:Alzheimer Disease United States frontal lobe | ventricular fluid Arsenic | Cadmium | Chromium | Copper | Iron | Lead | Manganese | Mercury | Nickel | Tin | Vanadium | Zinc Details Alzheimer Disease
35. Maheswaran R, et al. (2014). We found no evidence of association between outdoor particulate matter less than 10 microns in diameter (PM10) and nitrogen dioxide (NO2) concentrations and ischemic stroke subtypes but there was a suggestion that living in areas with elevated outdoor PM10 and NO2 concentrations might be associated with increased incidence of mild, but not severe, ischemic stroke. Nitrogen Dioxide | Particulate Matter Study subjects United Kingdom air, ambient Nitrogen Dioxide | Particulate Matter Details Stroke
36. Oudin A, et al. (2016). Betula Study We observed associations between dementia incidence and local traffic pollution that remained after adjusting for known risk factors. Nitrogen Oxides Study subjects Sweden Nitrogen Oxides Details Alzheimer Disease | Dementia, Vascular
37. Ren C, et al. (2010). Exposure to ozone was associated with specific cause mortality in eastern Massachusetts during May-September, 1995-2002. Ozone Subjects with disease:Death United States Ozone Details Cardiovascular Diseases | Death | Diabetes Mellitus | Respiration Disorders | Stroke
38. Kirrane EF, et al. (2015). Agricultural Health Study (AHS) We observed positive associations of Parkinson disease with ozone and fine particulate matter in North Carolina but not in Iowa. Ozone | Particulate Matter Workers United States Details Parkinson Disease
39. Goldman SM, et al. (2012). Agricultural Health Study (AHS) | Farming and Movement Evaluation Study (FAME) The present study tested the hypothesis that the association between paraquat and Parkinson Disease risk is enhanced in those with homozygous deletions of GSTT1 or GSTM1. genetics Paraquat Subjects with gene influence:GSTM1 | Subjects with gene influence:GSTT1 | Workers United States Details Agricultural Workers' Diseases | Parkinson Disease
40. Furlong M, et al. (2015). Farming and Movement Evaluation Study (FAME) Although sample size was limited, protective glove use and hygiene practices appeared to be important modifiers of the association between pesticides and Parkinson disease and may reduce risk of Parkinson disease associated with certain pesticides. Paraquat | Permethrin | Rotenone | Trifluralin Workers United States Details Parkinson Disease
41. Tanner CM, et al. (2011). Agricultural Health Study (AHS) | Farming and Movement Evaluation Study (FAME) Parkinson's Disease (PD) was positively associated with two groups of pesticides defined by mechanisms implicated experimentally-those that impair mitochondrial function and those that increase oxidative stress-supporting a role for these mechanisms in PD pathophysiology. Paraquat | Rotenone Workers United States Details Agricultural Workers' Diseases | Parkinson Disease
42. O'Donnell MJ, et al. (2011). These results do not support the hypothesis that short-term increases in particulate matter PM2.5 levels are associated with ischemic stroke risk overall. However, specific patient subgroups (e.g., diabetes mellitus) may be at increased risk of particulate-related ischemic strokes. disease Particulate Matter Subjects with disease:Diabetes Mellitus Canada air, ambient Particulate Matter Details Ischemic Attack, Transient | Stroke
43. Kloog I, et al. (2012). In this paper we report, for the first time, that long term exposure to particulate matter (PM2.5) is associated with increased hospital admissions of the elderly (aged 65 and older) for all respiratory, cardiovascular disease, stroke, and diabetes. age Particulate Matter Study subjects United States Particulate Matter Details Cardiovascular Diseases | Diabetes Mellitus | Respiratory Tract Diseases | Stroke
44. Palacios N, et al. (2014). Nurses' Health Study (NHS) In summary, overall the results of this large cohort study of female nurses do not support an effect of air pollution on Parkinson Disease risk. Particulate Matter Workers United States air Particulate Matter Details Parkinson Disease
45. Kioumourtzoglou MA, et al. (2016). We conducted a large-scale, multi-city study to estimate the impact of long-term particulate matter <=2.5 microns city-wide exposure on city-wide hospital admissions for neurological outcomes, using data from Medicare enrollees in the northeastern United States. Particulate Matter Study subjects United States air Particulate Matter Details Alzheimer Disease | Dementia | Parkinson Disease
46. Lokken RP, et al. (2009). Epidemiologic studies of air pollution-related risk of acute cardiovascular events that assess exposure based on date of hospitalization likely underestimate the strength of associations. Particulate Matter Subjects with disease:Stroke United States air Particulate Matter Details
47. Diez Roux AV, et al. (2008). Multi-Ethnic Study of Atherosclerosis (MESA) In summary, we found some evidence of associations between particulate matter exposure and common carotid intimal-medial thickness, but associations with other measures of subclinical atherosclerosis were inconsistent. Particulate Matter Study subjects United States air Particulate Matter Details Carotid Artery Diseases
48. Pun VC, et al. (2017). National Social Life, Health and Aging Project (NSHAP) Ambient fine particulate matter was associated with depressive and anxiety symptoms, with associations the strongest among individuals with lower socioeconomic measures or among those with certain health-related characteristics. disease | socioeconomic status Particulate Matter Subjects with disease:Asthma | Subjects with disease:Emphysema | Subjects with disease:Heart Failure | Subjects with disease:Pulmonary Disease, Chronic Obstructive | Subjects with disease:Stroke | Study subjects United States air, ambient Particulate Matter Details Anxiety Disorders | Depressive Disorder
49. Chen CY, et al. (2017). Although Particulate Matter(10) plays a significant role in Parkinson Disease development, the associated chemical/metal compounds that are capable of inducing adverse biological mechanisms still warrant further exploration. Particulate Matter Study subjects Taiwan, Province of China Details Parkinson Disease
50. Power MC, et al. (2018). Atherosclerosis Risk in Communities (ARIC) Study Long-term past Particulate Matter (PM) exposure was not associated with markers of cerebrovascular disease. Higher long-term past PM exposures were associated with smaller deep-gray volumes overall, and higher PM2.5 exposures were associated with smaller brain volumes in the Minnesota site. Particulate Matter Study subjects United States air Particulate Matter Details Cerebrovascular Disorders | brain morphogenesis
1–50 of 62 results.