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Disease Central Nervous System Diseases

These are exposure studies associated with the disease and all of its children.

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1–50 of 66 results.
  Reference Associated Study Title Author's Summary Study Factors Stressor Receptors Country Medium Exposure Marker Measurements Outcome
1. Malek AM, et al. (2015). A potential association was found for exposure to ambient air concentrations of suspected neurotoxicant hazardous air pollutants, specifically aromatic solvents, among place of residence in 2002 and 1999 and risk of Amyotrophic Lateral Sclerosis. 1,1,1-trichloroethane | 1,1,2,2-tetrachloroethane | 2,4-dinitrotoluene | Acrylamide | allyl chloride | Arsenicals | Benzene | Cadmium Compounds | Carbon Disulfide | Carbon Tetrachloride | Chloroform | Cresols | Cyanides | ethylbenzene | Ethylene Dibromide | ethylene dichloride | Ethylene Oxide | Hexachlorobenzene | hexachloroethane | Hexanes | hydrazine | Lead | Manganese Compounds | Mercury Compounds | Methyl Chloride | Methylene Chloride | Nickel | Polychlorinated Biphenyls | Selenium Compounds | Styrene | Tetrachloroethylene | Toluene | Trichloroethylene | Vinyl Chloride | Xylenes Controls for disease:Amyotrophic Lateral Sclerosis | Subjects with disease:Amyotrophic Lateral Sclerosis United States 1,1,1-trichloroethane | 1,1,2,2-tetrachloroethane | 2,4-dinitrotoluene | Acrylamide | allyl chloride | Arsenicals | Benzene | Cadmium Compounds | Carbon Disulfide | Carbon Tetrachloride | Chloroform | Cresols | Cyanides | ethylbenzene | Ethylene Dibromide | ethylene dichloride | Ethylene Oxide | Hexachlorobenzene | hexachloroethane | Hexanes | hydrazine | Lead | Manganese Compounds | Mercury Compounds | Methyl Chloride | Methylene Chloride | Nickel | Polychlorinated Biphenyls | Selenium Compounds | Styrene | Tetrachloroethylene | Toluene | Trichloroethylene | Vinyl Chloride | Xylenes Details Amyotrophic Lateral Sclerosis
2. Mi T, et al. (2013). We describe two cases of acute toxic leukoencephalopathy in migrant workers who were occupationally exposed to organic solvents in construction materials. 1,2,3-trichloropropane | Solvents | Toluene Workers China blood | urine 1,2,3-trichloropropane | Benzoic Acid Details Leukoencephalopathies | Neurotoxicity Syndromes | Occupational Diseases
3. Kamel F, et al. (2007). Agricultural Health Study (AHS) This study suggests that exposure to certain pesticides may increase Parkinson's disease risk. 2,4,5-Trichlorophenoxyacetic Acid | Benomyl | butylate | Carbon Disulfide | Carbon Tetrachloride | cyanazine | Dicamba | Ethylene Dibromide | Lindane | mancozeb | Maneb | methyl bromide | Paraquat | pendimethalin | Pesticides | Phorate | tetrachloroisophthalonitrile Study subjects | Workers United States Details Agricultural Workers' Diseases | Parkinson Disease
4. Beard JD, et al. (2016). Genes and Environmental Exposures in Veterans with Amyotrophic Lateral Sclerosis (GENEVA) We evaluated associations between military-related factors and amyotrophic lateral sclerosis using data from a case-control study of US military veterans; among some of the positive associations (needing confirmation) were exposure to military herbicides, military nasopharyngeal radium, and Agent Orange. Agent Orange | Defoliants, Chemical | Radium Subjects with disease:Amyotrophic Lateral Sclerosis | Veterans United States Details Amyotrophic Lateral Sclerosis
5. Zhang P, et al. (2011). Long-term exposure to ambient air pollution is associated with the death of cardiovascular and cerebrovascular diseases among Chinese populations. The effects of air pollution were more evident in female that in male, and nonsmokers and residents with body mass index less than 18.5 were more vulnerable to outdoor air pollution. body mass index | sex | tobacco Air Pollutants Study subjects China air, ambient Nitrogen Dioxide | Particulate Matter | Sulfur Dioxide Details Cardiovascular Diseases | Cerebrovascular Disorders | Death
6. Andersen ZJ, et al. (2012). Danish Diet, Cancer, and Health Study (DCH) Long-term exposure to traffic-related air pollution may contribute to the development of ischemic but not hemorrhagic stroke, especially severe ischemic strokes leading to death within 30 days. Air Pollutants Study subjects Denmark Nitrogen Dioxide Details Brain Ischemia | Cerebral Hemorrhage | Stroke
7. Liu R, et al. (2016). Parkinson's Genes and Environment Study (PAGE) Overall, we found limited evidence for an association between exposures to ambient particulate matter PM10, PM2.5, or nitrogen dioxide and Parkinson disease risk; however, the suggestive evidence that exposures to PM2.5 and PM10 may increase disease risk among female never-smokers warrants further investigation. sex | tobacco Air Pollutants Controls for disease:Parkinson Disease | Subjects with disease:Parkinson Disease United States air, ambient Nitrogen Dioxide | Particulate Matter Details Parkinson Disease
8. Raaschou-Nielsen O, et al. (2011). Diet, Cancer and Health Study This hypothesis-generating study indicates that traffic-related air pollution might increase the risks for cervical and brain cancer, which should be tested in future studies. Air Pollutants | Vehicle Emissions Study subjects Denmark air Nitrogen Oxides Details Brain Neoplasms | Uterine Cervical Neoplasms
9. Kamel F, et al. (2012). Agricultural Health Study (AHS) The meta-analysis suggests that amyotrophic lateral sclerosis risk is associated with use of pesticides as a group, and our analysis of Agricultural Health Study data points to organochlorine insecticide use in particular. Aldrin | DDT | Dieldrin | Herbicides | Hydrocarbons, Chlorinated | Pesticides | Pyrethrins | Toxaphene Study subjects | Workers United States Details Agricultural Workers' Diseases | Amyotrophic Lateral Sclerosis
10. Kamel F, et al. (2014). Agricultural Health Study (AHS) | Farming and Movement Evaluation Study (FAME) Polyunsaturated fatty acid intake was consistently associated with lower Parkinson's disease (PD) risk, and dietary fats modified the association of PD risk with pesticide exposure. alpha-Linolenic Acid | Fatty Acids | Fatty Acids, Unsaturated | Paraquat | Rotenone Controls for disease:Parkinson Disease | Subjects with disease:Parkinson Disease | Workers United States Details Agricultural Workers' Diseases | Parkinson Disease
11. Vinceti M, et al. (2010). Based on these results, coupled with other epidemiologic data and with findings from animal studies that show specific toxicity of the trace element on motor neurons, we hypothesize that dietary intake of inorganic selenium through drinking water increases the risk for amyotrophic lateral sclerosis. diet Aluminum | Arsenic | Cadmium | Chromium | Copper | Iron | Lead | Lithium | Manganese | Selenic Acid | Zinc Study subjects Italy water, well Aluminum | Arsenic | Cadmium | Chromium | Copper | Iron | Lead | Lithium | Manganese | Selenic Acid | Zinc Details Amyotrophic Lateral Sclerosis
12. Rondeau V, et al. (2009). Aluminum Maladie d'Alzheimer (ALMA+) | Personnes Agees Quid Study (PAQUID) We found that the cognitive decline and the risk of dementia were higher for high consumption of Aluminum from drinking water. age Aluminum | Silicon Dioxide Study subjects France water, drinking, bottled | water, tap Aluminum | Silicon Dioxide Details Alzheimer Disease | cognition
13. Moon KA, et al. (2013). Strong Heart Study (SHS) Low to moderate chronic arsenic exposure, as measured in urine, was prospectively associated with cardiovascular disease incidence and mortality. Arsenic Study subjects United States urine Arsenic Details Cardiovascular Diseases | Coronary Disease | Death | Stroke
14. Wang CH, et al. (2002). Carotid atherosclerosis is associated with ingested inorganic arsenic, showing a significant biological gradient. Arsenic Study subjects Taiwan, Province of China Arsenic Details Carotid Artery Diseases
15. Rahman M, et al. (2014). The result suggests that arsenic exposure from drinking water was associated with increased stroke mortality risk and was more significant in women compared to men. diet | sex Arsenic Controls for disease:Death | Subjects with disease:Death | Controls for disease:Stroke | Subjects with disease:Stroke | Study subjects Bangladesh water, well Arsenic Details Death | Stroke
16. Wang CH, et al. (2010). QT dispersion may be indicated as an early biomarker for atherosclerotic diseases and a significant and strong predictor of cardiovascular mortality in populations with chronic arsenic exposure. Arsenic Study subjects Taiwan, Province of China Details Carotid Artery Diseases | Coronary Artery Disease | regulation of ventricular cardiac muscle cell membrane repolarization
17. Thorpe N, et al. (2005). This hypothesis-generating study explores spatial patterns of childhood cancers in Maryland and investigates their potential associations with herbicides and nitrates in groundwater. Atrazine | metolachlor | Nitrates Children United States Details Bone Neoplasms | Brain Neoplasms | Leukemia | Lymphoma
18. Bove FJ, et al. (2014). We found elevated hazard ratios (with wide confidence intervals) at Camp Lejeune for causes of death from cancers of kidney, liver, esophagus, cervix, multiple myeloma, Hodgkin lymphoma, and amyotrophic lateral sclerosis; however, because less than 6% of cohort had died, long-term follow-up is necessary to comprehensively assess effects of drinking water exposures at the base. diet Benzene | Tetrachloroethylene | Vinyl Chloride | Water Pollutants, Chemical Military personnel United States water, drinking Benzene | Tetrachloroethylene | Trichloroethylene | Vinyl Chloride Details Amyotrophic Lateral Sclerosis | Death | Esophageal Neoplasms | Hodgkin Disease | Kidney Neoplasms | Liver Neoplasms | Multiple Myeloma | Uterine Cervical Neoplasms
19. Barregard L, et al. (2016). Malmo Diet and Cancer Study Blood cadmium in the highest quartile was associated with incident cardiovascular disease and mortality in our population-based samples of Swedish adults. tobacco Cadmium Study subjects Sweden blood Cadmium Details Cardiovascular Diseases | Myocardial Ischemia | Stroke
20. Peters JL, et al. (2010). National Health and Nutrition Examination Survey (NHANES) Environmental exposure to cadmium was associated with significantly increased stroke and heart failure prevalence. sex | tobacco Cadmium Study subjects United States blood | urine Cadmium Details Heart Failure | Stroke
21. Hecht EM, et al. (2016). National Health and Nutrition Examination Survey (NHANES) These descriptive data from a nationally representative sample suggest that cadmium is related to cardiovascular outcomes even after adjustment for smoking status. Cadmium Study subjects United States blood | urine Cadmium Details Myocardial Infarction | Stroke
22. Min JY, et al. (2016). National Health and Nutrition Examination Survey (NHANES) We observed a significant association between blood cadmium levels and Alzheimer disease mortality among older adults in the US. age Cadmium Controls for disease:Diabetes Mellitus | Subjects with disease:Diabetes Mellitus | Controls for disease:Hypertension | Subjects with disease:Hypertension | Study subjects United States blood Cadmium Details Alzheimer Disease
23. Ferrandiz J, et al. (2004). We used exposure analysis to assess the effect of both protective factors-calcium and magnesium-on mortality from cerebrovascular (ICD-9 430-438) and ischemic heart (ICD-9 410-414) diseases. This study provides statistical evidence of the relationship between mortality from cardiovascular diseases and hardness of drinking water. Calcium | Magnesium Study subjects Spain Details Cardiovascular Diseases | Cerebrovascular Disorders | Death
24. Ritz B, et al. (2016). We found ambient air pollution from traffic sources to be associated with risk of Parkinson's Disease, with a 9% higher risk (95% CI: 3, 16.0%) per interquartile range increase (2.97 micrograms per cubic meter) in modeled nitrogen dioxide. Carbon Monoxide | Nitric Oxide | Nitrogen Dioxide Controls for disease:Parkinson Disease | Subjects with disease:Parkinson Disease Denmark Carbon Monoxide | Nitric Oxide | Nitrogen Dioxide Details Parkinson Disease
25. Milojevic A, et al. (2014). This study found no clear evidence for pollution effects on ST-elevation myocardial infarctions and stroke, which ultimately represent thrombogenic processes, though it did for pulmonary embolism. age | sex Carbon Monoxide | Nitrogen Dioxide | Ozone | Particulate Matter | Sulfur Dioxide Study subjects United Kingdom air, ambient Carbon Monoxide | Nitrogen Dioxide | Ozone | Particulate Matter | Sulfur Dioxide Details Arrhythmias, Cardiac | Atrial Fibrillation | Cardiovascular Diseases | Death | Stroke
26. Manthripragada AD, et al. (2010). Parkinson's Environment and Genes Study (PEG) The increase in risk we observed among PON1-55 variant carriers for specific organophosphates metabolized by PON1 underscores the importance of considering susceptibility factors when studying environmental exposures in Parkinson disease. genetics Chlorpyrifos | Diazinon | Pesticides Subjects with gene influence:PON1 United States Chlorpyrifos | Diazinon | Pesticides Details Parkinson Disease
27. Shcherbatykh I, et al. (2005). These results suggest that living near a source of persistent organic pollutants contamination constitutes a risk of exposure and an increased risk of acquiring cerebrovascular disease. age | race | sex Dioxins | Pesticides | Polychlorinated Biphenyls Study subjects United States Details Cerebral Infarction
28. Yu Y, et al. (2014). Commercial pesticide (occupational exposure) and fertilizer (residential exposure) were both significantly associated with amyotrophic lateral sclerosis in a randomly selected set of patients; these results need to be interpreted cautiously given the small sample size and the lack of direct exposure measures, but they suggest that environmental, occupational, and residential factors warrant close attention in studies examining risk factors for this disease. Fertilizers | Pesticides Controls for disease:Amyotrophic Lateral Sclerosis | Subjects with disease:Amyotrophic Lateral Sclerosis United States Details Amyotrophic Lateral Sclerosis
29. Su FC, et al. (2016). In this study, persistent environmental pollutants measured in blood were significantly associated with amyotrophic lateral sclerosis and may represent modifiable disease risk factors. Flame Retardants | Pesticides | Polychlorinated Biphenyls Controls for disease:Amyotrophic Lateral Sclerosis | Subjects with disease:Amyotrophic Lateral Sclerosis United States plasma 2,2',3,5,5',6-hexachlorobiphenyl | 2,2',4,4',5-brominated diphenyl ether | 2,2',4,4'-tetrabromodiphenyl ether | 2,3',4,4',5-pentachlorobiphenyl | beta-hexachlorocyclohexane | Chlordan | Dichlorodiphenyl Dichloroethylene | dimethyl 2,3,5,6-tetrachloroterephthalate | hexabromodiphenyl ether 154 | Hexachlorobenzene | PCB 180 | pentabrominated diphenyl ether 100 | pentabromodiphenyl ether | pentachlorobenzene | Polychlorinated Biphenyls | tetrabromobisphenol A Details Amyotrophic Lateral Sclerosis
30. Louis ED, et al. (2011). Blood harmane and lead concentrations separately correlated with total tremor scores. Participants with high blood concentrations of both toxicants had the highest tremor scores, suggesting an additive effect of these toxicants on tremor severity. harman | Lead Controls for disease:Essential Tremor | Subjects with disease:Essential Tremor United States blood harman | Lead Details Essential Tremor
31. Narayan S, et al. (2015). This study lends support to a previous report that commonly used pesticides, specifically organochlorines and organophosphorous compounds, and variant ABCB1 genotypes at two polymorphic sites jointly increase risk of Parkinson's Disease. genetics Hydrocarbons, Chlorinated | Organophosphorus Compounds | Pesticides Subjects with gene influence:ABCB1 | Workers United States Details Parkinson Disease
32. Searles Nielsen S, et al. (2010). West Coast Childhood Brain Tumor Study Based on known effects of these variants, these results suggest that exposure in childhood to organophosphorus and perhaps to carbamate insecticides in combination with a reduced ability to detoxify them may be associated with childhood brain tumors. age Insecticides Subjects with gene influence:BCHE | Subjects with gene influence:FMO1 | Subjects with gene influence:PON1 United States Details Brain Neoplasms
33. Liao LM, et al. (2016). Shanghai Men's Health Study (SMHS) | Shanghai Women's Health Study (SWHS) In conclusion, our findings, though limited by small numbers of cases, suggest that lead exposure is associated with an increased risk of several cancers, in particular, meningioma, brain cancer, and kidney cancer. Lead Study subjects China Lead Details Brain Neoplasms | Kidney Neoplasms | Lung Neoplasms | Meningioma | Stomach Neoplasms
34. Weisskopf MG, et al. (2010). Normative Aging Study (NAS) These findings, using an objective biological marker of cumulative lead exposure among typical Parkinson Disease (PD) patients seen in our movement disorders clinics, strengthen the evidence that cumulative exposure to lead increases the risk of PD. Lead Study subjects United States patella | tibia Lead Details Parkinson Disease
35. Fang F, et al. (2010). Genes and Environmental Exposures in Veterans with Amyotrophic Lateral Sclerosis (GENEVA) | Veterans with ALS and Lead Exposure (VALE) In summary, we found that elevated blood lead level was associated with higher odds of Amyotrophic Lateral Sclerosis among US veterans, regardless of bone turnover or ALAD genotype. Lead Subjects with disease:Amyotrophic Lateral Sclerosis | Subjects with disease:Motor Neuron Disease | Subjects with disease:Muscular Atrophy, Spinal | Veterans United States blood Lead Details Amyotrophic Lateral Sclerosis
36. Ritz BR, et al. (2009). Our population-based case-control study of Parkinson's Disease (PD) conducted in a California population heavily exposed to pesticides replicates and extends evidence for an association between dopamine transporter (DAT) variants and PD and highlights possible interactions of disease-associated DAT susceptibility alleles and pesticide exposure. genetics Maneb | Paraquat Subjects with gene influence:SLC6A3 | Workers United States Details Parkinson Disease
37. Costello S, et al. (2009). This study provides evidence that exposure to a combination of maneb and paraquat increases Parkinson's Disease risk, particularly in younger subjects and/or when exposure occurs at younger ages. age Maneb | Paraquat Study subjects United States Details Parkinson Disease
38. Searles Nielsen S, et al. (2015). Midwestern US Welders Cohort We assessed DNA methylation at three CpG sites in NOS2 gene exon 1 from the blood of 201 welders (exposed to manganese in fumes), and found parkinsonism cases had lower mean NOS2 methylation (specifically at site 8329 in an exonic splicing enhancer). Manganese Workers United States blood NOS2 Details Parkinson Disease, Secondary
39. Szabo ST, et al. (2016). We examined the relationship between metal levels in brain tissue and ventricular fluid from postmortem samples of Alzheimer disease cases and controls; we confirmed previous work suggesting an increase in iron in Alzheimer brain tissue and identified arsenic as a metal of interest for further evaluation. Metals Controls for disease:Alzheimer Disease | Subjects with disease:Alzheimer Disease United States frontal lobe | ventricular fluid Arsenic | Cadmium | Chromium | Copper | Iron | Lead | Manganese | Mercury | Nickel | Tin | Vanadium | Zinc Details Alzheimer Disease
40. Maheswaran R, et al. (2014). We found no evidence of association between outdoor particulate matter less than 10 microns in diameter (PM10) and nitrogen dioxide (NO2) concentrations and ischemic stroke subtypes but there was a suggestion that living in areas with elevated outdoor PM10 and NO2 concentrations might be associated with increased incidence of mild, but not severe, ischemic stroke. Nitrogen Dioxide | Particulate Matter Study subjects United Kingdom air, ambient Nitrogen Dioxide | Particulate Matter Details Stroke
41. Oudin A, et al. (2016). Betula Study We observed associations between dementia incidence and local traffic pollution that remained after adjusting for known risk factors. Nitrogen Oxides Study subjects Sweden Nitrogen Oxides Details Alzheimer Disease | Dementia, Vascular
42. Ren C, et al. (2010). Exposure to ozone was associated with specific cause mortality in eastern Massachusetts during May-September, 1995-2002. Ozone Subjects with disease:Death United States Ozone Details Cardiovascular Diseases | Death | Diabetes Mellitus | Respiration Disorders | Stroke
43. Kirrane EF, et al. (2015). Agricultural Health Study (AHS) We observed positive associations of Parkinson disease with ozone and fine particulate matter in North Carolina but not in Iowa. Ozone | Particulate Matter Workers United States Details Parkinson Disease
44. Goldman SM, et al. (2012). Agricultural Health Study (AHS) | Farming and Movement Evaluation Study (FAME) The present study tested the hypothesis that the association between paraquat and Parkinson Disease risk is enhanced in those with homozygous deletions of GSTT1 or GSTM1. genetics Paraquat Subjects with gene influence:GSTM1 | Subjects with gene influence:GSTT1 | Workers United States Details Agricultural Workers' Diseases | Parkinson Disease
45. Furlong M, et al. (2015). Farming and Movement Evaluation Study (FAME) Although sample size was limited, protective glove use and hygiene practices appeared to be important modifiers of the association between pesticides and Parkinson disease and may reduce risk of Parkinson disease associated with certain pesticides. Paraquat | Permethrin | Rotenone | Trifluralin Workers United States Details Parkinson Disease
46. Tanner CM, et al. (2011). Agricultural Health Study (AHS) | Farming and Movement Evaluation Study (FAME) Parkinson's Disease (PD) was positively associated with two groups of pesticides defined by mechanisms implicated experimentally-those that impair mitochondrial function and those that increase oxidative stress-supporting a role for these mechanisms in PD pathophysiology. Paraquat | Rotenone Workers United States Details Agricultural Workers' Diseases | Parkinson Disease
47. Chen CY, et al. (2017). Although Particulate Matter(10) plays a significant role in Parkinson Disease development, the associated chemical/metal compounds that are capable of inducing adverse biological mechanisms still warrant further exploration. Particulate Matter Study subjects Taiwan, Province of China Details Parkinson Disease
48. Palacios N, et al. (2014). Nurses' Health Study (NHS) In summary, overall the results of this large cohort study of female nurses do not support an effect of air pollution on Parkinson Disease risk. Particulate Matter Workers United States air Particulate Matter Details Parkinson Disease
49. Kloog I, et al. (2012). In this paper we report, for the first time, that long term exposure to particulate matter (PM2.5) is associated with increased hospital admissions of the elderly (aged 65 and older) for all respiratory, cardiovascular disease, stroke, and diabetes. age Particulate Matter Study subjects United States Particulate Matter Details Cardiovascular Diseases | Diabetes Mellitus | Respiratory Tract Diseases | Stroke
50. Kioumourtzoglou MA, et al. (2016). We conducted a large-scale, multi-city study to estimate the impact of long-term particulate matter <=2.5 microns city-wide exposure on city-wide hospital admissions for neurological outcomes, using data from Medicare enrollees in the northeastern United States. Particulate Matter Study subjects United States air Particulate Matter Details Alzheimer Disease | Dementia | Parkinson Disease
1–50 of 66 results.