Skip navigation

Disease Central Nervous System Diseases

These are exposure studies associated with the disease and all of its children.

Send correction
1–50 of 55 results.
  Reference Associated Study Title Author's Summary Study Factors Stressor Receptors Country Medium Exposure Marker Measurements Outcome
1. Malek AM, et al. (2015). A potential association was found for exposure to ambient air concentrations of suspected neurotoxicant hazardous air pollutants, specifically aromatic solvents, among place of residence in 2002 and 1999 and risk of Amyotrophic Lateral Sclerosis. 1,1,1-trichloroethane | 1,1,2,2-tetrachloroethane | 2,4-dinitrotoluene | Acrylamide | allyl chloride | Arsenicals | Benzene | Cadmium Compounds | Carbon Disulfide | Carbon Tetrachloride | Chloroform | Cresols | Cyanides | ethylbenzene | Ethylene Dibromide | ethylene dichloride | Ethylene Oxide | Hexachlorobenzene | hexachloroethane | Hexanes | hydrazine | Lead | Manganese Compounds | Mercury Compounds | Methyl Chloride | Methylene Chloride | Nickel | Polychlorinated Biphenyls | Selenium Compounds | Styrene | Tetrachloroethylene | Toluene | Trichloroethylene | Vinyl Chloride | Xylenes Controls for disease:Amyotrophic Lateral Sclerosis | Subjects with disease:Amyotrophic Lateral Sclerosis United States 1,1,1-trichloroethane | 1,1,2,2-tetrachloroethane | 2,4-dinitrotoluene | Acrylamide | allyl chloride | Arsenicals | Benzene | Cadmium Compounds | Carbon Disulfide | Carbon Tetrachloride | Chloroform | Cresols | Cyanides | ethylbenzene | Ethylene Dibromide | ethylene dichloride | Ethylene Oxide | Hexachlorobenzene | hexachloroethane | Hexanes | hydrazine | Lead | Manganese Compounds | Mercury Compounds | Methyl Chloride | Methylene Chloride | Nickel | Polychlorinated Biphenyls | Selenium Compounds | Styrene | Tetrachloroethylene | Toluene | Trichloroethylene | Vinyl Chloride | Xylenes Details Amyotrophic Lateral Sclerosis
2. Mi T, et al. (2013). We describe two cases of acute toxic leukoencephalopathy in migrant workers who were occupationally exposed to organic solvents in construction materials. 1,2,3-trichloropropane | Solvents | Toluene Workers China blood | urine 1,2,3-trichloropropane | Benzoic Acid Details Leukoencephalopathies | Neurotoxicity Syndromes | Occupational Diseases
3. Kamel F, et al. (2007). Agricultural Health Study (AHS) This study suggests that exposure to certain pesticides may increase Parkinson's disease risk. 2,4,5-Trichlorophenoxyacetic Acid | Benomyl | butylate | Carbon Disulfide | Carbon Tetrachloride | cyanazine | Dicamba | Ethylene Dibromide | Lindane | mancozeb | Maneb | methyl bromide | Paraquat | pendimethalin | Pesticides | Phorate | tetrachloroisophthalonitrile Study subjects | Workers United States Details Agricultural Workers' Diseases | Parkinson Disease
4. Beard JD, et al. (2016). Genes and Environmental Exposures in Veterans with Amyotrophic Lateral Sclerosis (GENEVA) We evaluated associations between military-related factors and amyotrophic lateral sclerosis using data from a case-control study of US military veterans; among some of the positive associations (needing confirmation) were exposure to military herbicides, military nasopharyngeal radium, and Agent Orange. Agent Orange | Defoliants, Chemical | Radium Subjects with disease:Amyotrophic Lateral Sclerosis | Veterans United States Details Amyotrophic Lateral Sclerosis
5. Andersen ZJ, et al. (2012). Danish Diet, Cancer, and Health cohort Study Long-term exposure to traffic-related air pollution may contribute to the development of ischemic but not hemorrhagic stroke, especially severe ischemic strokes leading to death within 30 days. Air Pollutants Study subjects Denmark Nitrogen Dioxide Details Brain Ischemia | Cerebral Hemorrhage | Stroke
6. Liu R, et al. (2016). Parkinson's Genes and Environment Study (PAGE) Overall, we found limited evidence for an association between exposures to ambient particulate matter PM10, PM2.5, or nitrogen dioxide and Parkinson disease risk; however, the suggestive evidence that exposures to PM2.5 and PM10 may increase disease risk among female never-smokers warrants further investigation. sex | tobacco Air Pollutants Controls for disease:Parkinson Disease | Subjects with disease:Parkinson Disease United States air, ambient Nitrogen Dioxide | Particulate Matter Details Parkinson Disease
7. Zhang P, et al. (2011). Long-term exposure to ambient air pollution is associated with the death of cardiovascular and cerebrovascular diseases among Chinese populations. The effects of air pollution were more evident in female that in male, and nonsmokers and residents with body mass index less than 18.5 were more vulnerable to outdoor air pollution. body mass index | sex | tobacco Air Pollutants Study subjects China air, ambient Nitrogen Dioxide | Particulate Matter | Sulfur Dioxide Details Cardiovascular Diseases | Cerebrovascular Disorders | Death
8. Raaschou-Nielsen O, et al. (2011). Diet, Cancer and Health Study This hypothesis-generating study indicates that traffic-related air pollution might increase the risks for cervical and brain cancer, which should be tested in future studies. Air Pollutants | Vehicle Emissions Study subjects Denmark air Nitrogen Oxides Details Brain Neoplasms | Uterine Cervical Neoplasms
9. Kamel F, et al. (2012). Agricultural Health Study (AHS) The meta-analysis suggests that amyotrophic lateral sclerosis risk is associated with use of pesticides as a group, and our analysis of Agricultural Health Study data points to organochlorine insecticide use in particular. Aldrin | DDT | Dieldrin | Herbicides | Hydrocarbons, Chlorinated | Pesticides | Pyrethrins | Toxaphene Study subjects | Workers United States Details Agricultural Workers' Diseases | Amyotrophic Lateral Sclerosis
10. Kamel F, et al. (2014). Agricultural Health Study (AHS) | Farming and Movement Evaluation Study (FAME) Polyunsaturated fatty acid intake was consistently associated with lower Parkinson's disease (PD) risk, and dietary fats modified the association of PD risk with pesticide exposure. alpha-Linolenic Acid | Fatty Acids | Fatty Acids, Unsaturated | Paraquat | Rotenone Controls for disease:Parkinson Disease | Subjects with disease:Parkinson Disease | Workers United States Details Agricultural Workers' Diseases | Parkinson Disease
11. Vinceti M, et al. (2010). Based on these results, coupled with other epidemiologic data and with findings from animal studies that show specific toxicity of the trace element on motor neurons, we hypothesize that dietary intake of inorganic selenium through drinking water increases the risk for amyotrophic lateral sclerosis. diet Aluminum | Arsenic | Cadmium | Chromium | Copper | Iron | Lead | Lithium | Manganese | Selenic Acid | Zinc Study subjects Italy water, well Aluminum | Arsenic | Cadmium | Chromium | Copper | Iron | Lead | Lithium | Manganese | Selenic Acid | Zinc Details Amyotrophic Lateral Sclerosis
12. Rondeau V, et al. (2009). Aluminum Maladie d'Alzheimer (ALMA+) | Personnes Agees Quid Study (PAQUID) We found that the cognitive decline and the risk of dementia were higher for high consumption of Aluminum from drinking water. age Aluminum | Silicon Dioxide Study subjects France water, drinking, bottled | water, tap Aluminum | Silicon Dioxide Details Alzheimer Disease | cognition
13. Thorpe N, et al. (2005). This hypothesis-generating study explores spatial patterns of childhood cancers in Maryland and investigates their potential associations with herbicides and nitrates in groundwater. Atrazine | metolachlor | Nitrates Children United States Details Bone Neoplasms | Brain Neoplasms | Leukemia | Lymphoma
14. Min JY, et al. (2016). National Health and Nutrition Examination Survey (NHANES) We observed a significant association between blood cadmium levels and Alzheimer disease mortality among older adults in the US. age Cadmium Controls for disease:Diabetes Mellitus | Subjects with disease:Diabetes Mellitus | Controls for disease:Hypertension | Subjects with disease:Hypertension | Study subjects United States blood Cadmium Details Alzheimer Disease
15. Barregard L, et al. (2016). Malmo Diet and Cancer Study Blood cadmium in the highest quartile was associated with incident cardiovascular disease and mortality in our population-based samples of Swedish adults. tobacco Cadmium Study subjects Sweden blood Cadmium Details Cardiovascular Diseases | Myocardial Ischemia | Stroke
16. Peters JL, et al. (2010). National Health and Nutrition Examination Survey (NHANES) Environmental exposure to cadmium was associated with significantly increased stroke and heart failure prevalence. sex | tobacco Cadmium Study subjects United States blood | urine Cadmium Details Heart Failure | Stroke
17. Ferrandiz J, et al. (2004). We used exposure analysis to assess the effect of both protective factors-calcium and magnesium-on mortality from cerebrovascular (ICD-9 430-438) and ischemic heart (ICD-9 410-414) diseases. This study provides statistical evidence of the relationship between mortality from cardiovascular diseases and hardness of drinking water. Calcium | Magnesium Study subjects Spain Details Cardiovascular Diseases | Cerebrovascular Disorders | Death
18. Ritz B, et al. (2016). We found ambient air pollution from traffic sources to be associated with risk of Parkinson's Disease, with a 9% higher risk (95% CI: 3, 16.0%) per interquartile range increase (2.97 micrograms per cubic meter) in modeled nitrogen dioxide. Carbon Monoxide | Nitric Oxide | Nitrogen Dioxide Controls for disease:Parkinson Disease | Subjects with disease:Parkinson Disease Denmark Carbon Monoxide | Nitric Oxide | Nitrogen Dioxide Details Parkinson Disease
19. Milojevic A, et al. (2014). This study found no clear evidence for pollution effects on ST-elevation myocardial infarctions and stroke, which ultimately represent thrombogenic processes, though it did for pulmonary embolism. age | sex Carbon Monoxide | Nitrogen Dioxide | Ozone | Particulate Matter | Sulfur Dioxide Study subjects United Kingdom air, ambient Carbon Monoxide | Nitrogen Dioxide | Ozone | Particulate Matter | Sulfur Dioxide Details Arrhythmias, Cardiac | Atrial Fibrillation | Cardiovascular Diseases | Death | Stroke
20. Manthripragada AD, et al. (2010). Parkinson's Environment and Genes Study (PEG) The increase in risk we observed among PON1-55 variant carriers for specific organophosphates metabolized by PON1 underscores the importance of considering susceptibility factors when studying environmental exposures in Parkinson disease. genetics Chlorpyrifos | Diazinon | Pesticides Subjects with gene influence:PON1 United States Chlorpyrifos | Diazinon | Pesticides Details Parkinson Disease
21. Shcherbatykh I, et al. (2005). These results suggest that living near a source of persistent organic pollutants contamination constitutes a risk of exposure and an increased risk of acquiring cerebrovascular disease. age | race | sex Dioxins | Pesticides | Polychlorinated Biphenyls Study subjects United States Details Cerebral Infarction
22. Yu Y, et al. (2014). Commercial pesticide (occupational exposure) and fertilizer (residential exposure) were both significantly associated with amyotrophic lateral sclerosis in a randomly selected set of patients; these results need to be interpreted cautiously given the small sample size and the lack of direct exposure measures, but they suggest that environmental, occupational, and residential factors warrant close attention in studies examining risk factors for this disease. Fertilizers | Pesticides Controls for disease:Amyotrophic Lateral Sclerosis | Subjects with disease:Amyotrophic Lateral Sclerosis United States Details Amyotrophic Lateral Sclerosis
23. Louis ED, et al. (2011). Blood harmane and lead concentrations separately correlated with total tremor scores. Participants with high blood concentrations of both toxicants had the highest tremor scores, suggesting an additive effect of these toxicants on tremor severity. harman | Lead Controls for disease:Essential Tremor | Subjects with disease:Essential Tremor United States blood harman | Lead Details Essential Tremor
24. Narayan S, et al. (2015). This study lends support to a previous report that commonly used pesticides, specifically organochlorines and organophosphorous compounds, and variant ABCB1 genotypes at two polymorphic sites jointly increase risk of Parkinson's Disease. genetics Hydrocarbons, Chlorinated | Organophosphorus Compounds | Pesticides Subjects with gene influence:ABCB1 | Workers United States Details Parkinson Disease
25. Searles Nielsen S, et al. (2010). West Coast Childhood Brain Tumor Study Based on known effects of these variants, these results suggest that exposure in childhood to organophosphorus and perhaps to carbamate insecticides in combination with a reduced ability to detoxify them may be associated with childhood brain tumors. age Insecticides Subjects with gene influence:BCHE | Subjects with gene influence:FMO1 | Subjects with gene influence:PON1 United States Details Brain Neoplasms
26. Fang F, et al. (2010). Genes and Environmental Exposures in Veterans with Amyotrophic Lateral Sclerosis (GENEVA) | Veterans with ALS and Lead Exposure (VALE) In summary, we found that elevated blood lead level was associated with higher odds of Amyotrophic Lateral Sclerosis among US veterans, regardless of bone turnover or ALAD genotype. Lead Subjects with disease:Amyotrophic Lateral Sclerosis | Subjects with disease:Motor Neuron Disease | Subjects with disease:Muscular Atrophy, Spinal | Veterans United States blood Lead Details Amyotrophic Lateral Sclerosis
27. Weisskopf MG, et al. (2010). Normative Aging Study (NAS) These findings, using an objective biological marker of cumulative lead exposure among typical Parkinson Disease (PD) patients seen in our movement disorders clinics, strengthen the evidence that cumulative exposure to lead increases the risk of PD. Lead Study subjects United States patella | tibia Lead Details Parkinson Disease
28. Liao LM, et al. (2016). Shanghai Men's Health Study (SMHS) | Shanghai Women's Health Study (SWHS) In conclusion, our findings, though limited by small numbers of cases, suggest that lead exposure is associated with an increased risk of several cancers, in particular, meningioma, brain cancer, and kidney cancer. Lead Study subjects China Lead Details Brain Neoplasms | Kidney Neoplasms | Lung Neoplasms | Meningioma | Stomach Neoplasms
29. Ritz BR, et al. (2009). Our population-based case-control study of Parkinson's Disease (PD) conducted in a California population heavily exposed to pesticides replicates and extends evidence for an association between dopamine transporter (DAT) variants and PD and highlights possible interactions of disease-associated DAT susceptibility alleles and pesticide exposure. genetics Maneb | Paraquat Subjects with gene influence:SLC6A3 | Workers United States Details Parkinson Disease
30. Costello S, et al. (2009). This study provides evidence that exposure to a combination of maneb and paraquat increases Parkinson's Disease risk, particularly in younger subjects and/or when exposure occurs at younger ages. age Maneb | Paraquat Study subjects United States Details Parkinson Disease
31. Searles Nielsen S, et al. (2015). Midwestern US Welders Cohort We assessed DNA methylation at three CpG sites in NOS2 gene exon 1 from the blood of 201 welders (exposed to manganese in fumes), and found parkinsonism cases had lower mean NOS2 methylation (specifically at site 8329 in an exonic splicing enhancer). Manganese Workers United States blood NOS2 Details Parkinson Disease, Secondary
32. Szabo ST, et al. (2016). We examined the relationship between metal levels in brain tissue and ventricular fluid from postmortem samples of Alzheimer disease cases and controls; we confirmed previous work suggesting an increase in iron in Alzheimer brain tissue and identified arsenic as a metal of interest for further evaluation. Metals Controls for disease:Alzheimer Disease | Subjects with disease:Alzheimer Disease United States frontal lobe | ventricular fluid Arsenic | Cadmium | Chromium | Copper | Iron | Lead | Manganese | Mercury | Nickel | Tin | Vanadium | Zinc Details Alzheimer Disease
33. Maheswaran R, et al. (2014). We found no evidence of association between outdoor particulate matter less than 10 microns in diameter (PM10) and nitrogen dioxide (NO2) concentrations and ischemic stroke subtypes but there was a suggestion that living in areas with elevated outdoor PM10 and NO2 concentrations might be associated with increased incidence of mild, but not severe, ischemic stroke. Nitrogen Dioxide | Particulate Matter Study subjects United Kingdom air, ambient Nitrogen Dioxide | Particulate Matter Details Stroke
34. Oudin A, et al. (2016). Betula Study We observed associations between dementia incidence and local traffic pollution that remained after adjusting for known risk factors. Nitrogen Oxides Study subjects Sweden Nitrogen Oxides Details Alzheimer Disease | Dementia, Vascular
35. Ren C, et al. (2010). Exposure to ozone was associated with specific cause mortality in eastern Massachusetts during May-September, 1995-2002. Ozone Subjects with disease:Death United States Ozone Details Cardiovascular Diseases | Death | Diabetes Mellitus | Respiration Disorders | Stroke
36. Kirrane EF, et al. (2015). Agricultural Health Study (AHS) We observed positive associations of Parkinson disease with ozone and fine particulate matter in North Carolina but not in Iowa. Ozone | Particulate Matter Workers United States Details Parkinson Disease
37. Goldman SM, et al. (2012). Agricultural Health Study (AHS) | Farming and Movement Evaluation Study (FAME) The present study tested the hypothesis that the association between paraquat and Parkinson Disease risk is enhanced in those with homozygous deletions of GSTT1 or GSTM1. genetics Paraquat Subjects with gene influence:GSTM1 | Subjects with gene influence:GSTT1 | Workers United States Details Agricultural Workers' Diseases | Parkinson Disease
38. Furlong M, et al. (2015). Farming and Movement Evaluation Study (FAME) Although sample size was limited, protective glove use and hygiene practices appeared to be important modifiers of the association between pesticides and Parkinson disease and may reduce risk of Parkinson disease associated with certain pesticides. Paraquat | Permethrin | Rotenone | Trifluralin Workers United States Details Parkinson Disease
39. Tanner CM, et al. (2011). Agricultural Health Study (AHS) | Farming and Movement Evaluation Study (FAME) Parkinson's Disease (PD) was positively associated with two groups of pesticides defined by mechanisms implicated experimentally-those that impair mitochondrial function and those that increase oxidative stress-supporting a role for these mechanisms in PD pathophysiology. Paraquat | Rotenone Workers United States Details Agricultural Workers' Diseases | Parkinson Disease
40. Pun VC, et al. (2017). National Social Life, Health and Aging Project (NSHAP) Ambient fine particulate matter was associated with depressive and anxiety symptoms, with associations the strongest among individuals with lower socioeconomic measures or among those with certain health-related characteristics. disease | socioeconomic status Particulate Matter Subjects with disease:Asthma | Subjects with disease:Emphysema | Subjects with disease:Heart Failure | Subjects with disease:Pulmonary Disease, Chronic Obstructive | Subjects with disease:Stroke | Study subjects United States air, ambient Particulate Matter Details Anxiety Disorders | Depressive Disorder
41. Palacios N, et al. (2014). Nurses' Health Study (NHS) In summary, overall the results of this large cohort study of female nurses do not support an effect of air pollution on Parkinson Disease risk. Particulate Matter Workers United States air Particulate Matter Details Parkinson Disease
42. Kioumourtzoglou MA, et al. (2016). We conducted a large-scale, multi-city study to estimate the impact of long-term particulate matter <=2.5 microns city-wide exposure on city-wide hospital admissions for neurological outcomes, using data from Medicare enrollees in the northeastern United States. Particulate Matter Study subjects United States air Particulate Matter Details Alzheimer Disease | Dementia | Parkinson Disease
43. Kloog I, et al. (2012). In this paper we report, for the first time, that long term exposure to particulate matter (PM2.5) is associated with increased hospital admissions of the elderly (aged 65 and older) for all respiratory, cardiovascular disease, stroke, and diabetes. age Particulate Matter Study subjects United States Particulate Matter Details Cardiovascular Diseases | Diabetes Mellitus | Respiratory Tract Diseases | Stroke
44. O'Donnell MJ, et al. (2011). These results do not support the hypothesis that short-term increases in particulate matter PM2.5 levels are associated with ischemic stroke risk overall. However, specific patient subgroups (e.g., diabetes mellitus) may be at increased risk of particulate-related ischemic strokes. disease Particulate Matter Subjects with disease:Diabetes Mellitus Canada air, ambient Particulate Matter Details Ischemic Attack, Transient | Stroke
45. Lokken RP, et al. (2009). Epidemiologic studies of air pollution-related risk of acute cardiovascular events that assess exposure based on date of hospitalization likely underestimate the strength of associations. Particulate Matter Subjects with disease:Stroke United States air Particulate Matter Details
46. Diez Roux AV, et al. (2008). Multi-Ethnic Study of Atherosclerosis (MESA) In summary, we found some evidence of associations between particulate matter exposure and common carotid intimal-medial thickness, but associations with other measures of subclinical atherosclerosis were inconsistent. Particulate Matter Study subjects United States air Particulate Matter Details Carotid Artery Diseases
47. Rinsky JL, et al. (2013). Agricultural Health Study (AHS) No measure of overall or specific pesticide use was positively associated with mortality due to stroke; further investigation of incident stroke, rather than stroke mortality, as well as stroke subtypes, is needed to determine the full role of agricultural exposures and stroke. Pesticides Workers United States Details Death | Stroke
48. Paul KC, et al. (2015). We found that organophosphate pesticides were more strongly associated with Parkinson disease among participants with variant genotypes in NOS1, consistent with the importance of oxidative stress-inducing mechanisms. genetics Pesticides Subjects with gene influence:NOS1 | Controls for disease:Parkinson Disease | Subjects with disease:Parkinson Disease United States Details Parkinson Disease
49. Provost D, et al. (2007). CEREPHY Study These data suggest that a high level of occupational exposure to pesticides might be associated with an excess risk of brain tumours, and especially of gliomas. Pesticides Study subjects France Details Brain Neoplasms | Glioma
50. Dick FD, et al. (2007). The association of pesticide exposure with Parkinson's disease suggests a causative role; repeated traumatic loss of consciousness is also associated with increased risk. Pesticides Controls for disease:Parkinson Disease | Subjects with disease:Parkinson Disease Italy|Malta|
Romania|Sweden|
United Kingdom
Details
1–50 of 55 results.