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Disease Colonic Neoplasms

These chemicals are associated with Colonic Neoplasms or its descendants. A chemical has either a curated association to the disease (M marker/mechanism and/or T therapeutic) or an inferred association via a curated gene interaction.

1–50 of 6,728 results.
  Chemical Disease Direct Evidence Enrichment Analysis Inference Network Inference Score References
1. 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine Colonic Neoplasms M
70 genes: A2M | ACTA2 | ACTG2 | ALOX5 | APC | ASCL2 | BAX | BCL2 | CACNA2D1 | CAR4 | CCL20 | CCND1 | CCND2 | CDKN1A | CKM | CRYAB | CTNNB1 | CXCL10 | DEFA24 | DEFA-RS1 | DMBT1 | DNMT1 | EGFR | ERBB2 | GAP43 | GSTM5 | GUCY1A3 | HMGCS2 | HSPA2 | HSPB1 | ICAM1 | ID3 | IFNG | IGFBP1 | IL1B | ITGA7 | JUN | LPL | MAOB | MCM2 | MEP1A | MKI67 | MMP12 | MMP7 | MMP9 | MYC | NDRG2 | NFKB1 | NOS2 | NOX1 | NOX4 | PCNA | PCP4 | PLCB1 | PTGS2 | RATNP-3B | RELA | RHOJ | RNF34 | S100A9 | SERPINB5 | SH3KBP1 | SLC22A1 | SOD2 | SULT1A1 | TAGLN | TCF19 | TNF | TP53 | TPM3
167.69 58
2. Azoxymethane Colonic Neoplasms M
31 genes: APC | BAX | BCL2 | BIRC5 | CCND1 | CDKN1A | CXCL10 | FOLR1 | IFNG | IL1B | IL1RN | KRAS | LEP | MKI67 | MMP7 | MMP9 | MYC | NFKB1 | NOS2 | PCNA | PTGS2 | PTP4A3 | RELA | SLC19A1 | SRC | STAT3 | TNF | TNFSF10 | TP53 | TYMS | VEGFA
102.02 76
3. Diethylnitrosamine Colonic Neoplasms M
76 genes: A2M | ACTA2 | ACTG2 | APC | BAX | BCL2 | BIRC5 | CACNA2D1 | CAR4 | CBR1 | CCND1 | CDKN1A | CRYAB | CTNNB1 | CXCL10 | CYP26A1 | DMBT1 | DNMT1 | DPYD | EGFR | GAST | GSTM5 | HMGCS2 | HSPA2 | HSPB1 | ICAM1 | ID3 | IFNG | IGF2 | IGFBP1 | IL1B | JUN | KRAS | LEP | LPL | MAOB | MCM2 | MEP1A | MKI67 | MMP12 | MMP9 | MTHFR | MYC | NDRG2 | NFKB1 | NOS2 | NOTCH1 | NOX4 | ODC1 | PCNA | PCP4 | PLCB1 | PPARG | PROM1 | PTGS2 | RELA | RFC1 | S100A4 | S100A9 | SERPINB5 | SLC16A1 | SOD2 | SPARC | SRC | STAT3 | SULT1A1 | TAGLN | TCF19 | TGFBR2 | TNF | TNFSF10 | TP53 | TPM3 | TYMS | UMPS | VEGFA
73.04 62
4. DDT Colonic Neoplasms M
29 genes: BCL2 | CCND1 | CCND2 | CDKN1A | CTNNB1 | DNMT1 | ERBB2 | IGF2 | IL1B | JUN | LEP | LPL | LTF | MAP2K6 | MYC | NFKB1 | NOS2 | NOTCH1 | OXT | PPARG | PTGS2 | SERPINB5 | SOD2 | SPARC | STAT3 | TNF | TP53 | TYMS | VEGFA
61.27 41
Has associated exposure references.
5. Dextran Sulfate Colonic Neoplasms M
25 genes: APC | BAX | BCL2 | BIRC5 | CTNNB1 | CXCL10 | GAST | ICAM1 | IFNG | IL1B | IL1RN | LEP | MKI67 | MMP9 | NFKB1 | NOS2 | PCNA | PPARG | PTGS2 | RELA | SLC2A1 | STAT3 | TNF | TYMS | VEGFA
60.93 46
6. Hydrogen Peroxide Colonic Neoplasms M
72 genes: ACTA2 | ACTG2 | ALOX5 | APC | ATP7A | BAK1 | BAX | BCL2 | BECN1 | BIRC5 | CCL20 | CCND2 | CDKN1A | CKM | CTNNB1 | DNMT1 | EGFR | ERBB2 | FOLR1 | FZD2 | GUCY1A3 | HES1 | HSPA2 | HSPB1 | ICAM1 | ID3 | IFNG | IGF2 | IGFBP1 | IL1B | ITGA7 | JUN | KCNH2 | KRAS | LEP | LGR5 | LTF | MAP2K6 | MEP1A | MMP12 | MMP7 | MMP9 | MYC | NDRG2 | NFKB1 | NOS2 | NOX4 | ODC1 | PARK2 | PARP4 | PCNA | PPARG | PTGS2 | RECK | RELA | S100A4 | SERPINB5 | SH3KBP1 | SLC16A1 | SLC19A1 | SLC2A1 | SLC5A8 | SOD2 | SRC | STAT3 | SULT1A1 | TGFBR2 | TNF | TP53 | TPM3 | VEGFA | XAF1
59.70 64
7. Plant Preparations Colonic Neoplasms M
28 genes: ACTA2 | BAX | CCND1 | CDKN1A | CTNNB1 | CXCL10 | EGFR | FBP1 | GCG | ICAM1 | IFNG | IL1B | JUN | LEP | LPL | MYC | NFKB1 | NOS2 | ODC1 | PPARG | PTGS2 | RELA | SOD2 | SRC | SULT1A1 | TNF | TP53 | VEGFA
59.20 32
8. Methylnitrosourea Colonic Neoplasms M
28 genes: APC | BAX | BCL2 | BIRC5 | CBR1 | CCL20 | CCND1 | CDKN1A | CTNNB1 | DMBT1 | EGFR | ID3 | IFNG | IL1B | JUN | KRAS | LEP | MKI67 | MYC | NOS2 | PCNA | PPARG | RELA | SOD2 | SRC | TNF | TP53 | VEGFA
52.55 40
9. Deoxycholic Acid Colonic Neoplasms M
20 genes: BAX | BCL2 | CCL20 | CCND1 | CXCL10 | EGFR | ICAM1 | IFNG | IL1B | LEP | LPL | NFKB1 | PPARG | PTGS2 | RELA | SERPINB5 | SLC22A1 | SLCO1B3 | TNF | TP53
49.82 24
10. Glucose Colonic Neoplasms M
45 genes: ACTA2 | ALOX5 | APC | BAX | BCL2 | BECN1 | CCND1 | CDKN1A | CTNNB1 | CXCL10 | FOLR1 | GAST | GCG | HSPB1 | ICAM1 | ID3 | IFNG | IL1B | IL1RN | JUN | LEP | LPL | MMP7 | MMP9 | MYC | NDRG2 | NFKB1 | NOS2 | NOX1 | ODC1 | PCNA | PPARG | PTGS2 | RELA | SLC2A1 | SOD2 | SPARC | SRC | STAT3 | TGFBR2 | TNF | TNFRSF9 | TP53 | TPM3 | VEGFA
49.64 47
11. Nicotine Colonic Neoplasms M
41 genes: ALOX5 | BAX | BCL2 | BIRC5 | CACNA2D1 | CCND1 | CCND2 | CDKN1A | CRYAB | CYP26A1 | EGFR | FOLR1 | GAP43 | ICAM1 | ID3 | IL1B | JUN | KCNH2 | LEP | LPL | LTF | MAP2K6 | MMP7 | MMP9 | MYC | NFKB1 | NOS2 | NOX4 | PARK2 | PARP4 | PCNA | PTGS2 | RELA | SH3KBP1 | SLC19A1 | SOD2 | SRC | STAT3 | TNF | TP53 | VEGFA
48.10 37
12. Sulfasalazine Colonic Neoplasms M
23 genes: ACTA2 | BAX | BCL2 | CCND1 | CDKN1A | CTNNB1 | EGFR | ICAM1 | IFNG | IL1B | IL1RN | MMP9 | MTHFR | NFKB1 | NOS2 | ODC1 | PCNA | PPARG | PTGS2 | RELA | TNF | TPM3 | TYMP
45.88 33
13. 4-hydroxy-2-nonenal Colonic Neoplasms M
33 genes: ALOX5 | APC | BAX | BIRC5 | CCND1 | CCND2 | CDKN1A | CTNNB1 | CXCL10 | ERBB2 | HSPA2 | ICAM1 | IFNG | IL1B | IL1RN | ITGA7 | JUN | MKI67 | MMP9 | MYC | NFKB1 | NOS2 | NOTCH1 | PCNA | RELA | SERPINB5 | SOD2 | SRC | STAT3 | TNF | TP53 | VEGFA | XAF1
42.51 37
14. Iron Colonic Neoplasms M
26 genes: ATP7A | BCL2 | CCND1 | CDKN1A | DNMT1 | HMGCS2 | HSPB1 | ICAM1 | IFNG | IL1B | JUN | LEP | LTF | MAP2K6 | MYC | NOS2 | ODC1 | PCNA | PPARG | PTGS2 | S100A9 | SOD2 | SRC | TNF | TNFSF10 | TP53
40.68 32
15. Dietary Fats Colonic Neoplasms M
59 genes: A2M | ACTA2 | ACTG2 | APC | CAR4 | CCND1 | CDKN1A | CKM | CTNNB1 | CXCL10 | DNMT1 | DPYD | EGFR | GCG | HES1 | HMGCS2 | HSPA2 | HSPB1 | ICAM1 | ID3 | IFNG | IGFBP1 | IL1B | IL1RN | JUN | LEP | LPL | MAOB | MAP2K6 | MCM2 | MKI67 | MMP12 | MMP9 | MYC | NFKB1 | NOS2 | NOX4 | PCNA | PPARG | PROM1 | PTGS2 | RECK | RELA | S100A4 | S100A9 | SERTAD1 | SH3KBP1 | SLC16A1 | SLC2A1 | SOD2 | SPARC | STAT3 | SULT1A1 | TAGLN | TGFBR2 | TNF | TNFSF10 | UMPS | VEGFA
38.94 47
16. Caffeine Colonic Neoplasms M
27 genes: BAX | CCND1 | CDKN1A | CTNNB1 | DNMT1 | GAST | HSPB1 | ID3 | IGFBP1 | JUN | LEP | LPL | MMP7 | MYC | NFKB1 | NOS2 | PLCB1 | PPARG | PTGS2 | RELA | SLC16A1 | SLC2A1 | SOD2 | TNF | TP53 | TYMS | VEGFA
35.38 36
17. Lithocholic Acid Colonic Neoplasms M
19 genes: BAK1 | BAX | CTNNB1 | CYP26A1 | GCG | HMGCS2 | HSPB1 | ICAM1 | IL1B | JUN | LPL | MMP9 | PTGS2 | RELA | SLC2A1 | SLCO1B3 | TGFBR2 | TNF | VEGFA
34.27 25
18. Butylated Hydroxytoluene Colonic Neoplasms M
17 genes: ACTA2 | ALOX5 | CCND1 | CTNNB1 | KRAS | LEF1 | LEP | NFKB1 | PCNA | PPARG | PTGS2 | RELA | SLC2A1 | SOD2 | TNF | TP53 | VEGFA
32.73 32
19. alachlor Colonic Neoplasms M
14 genes: BAX | BCL2 | CCND1 | CCND2 | DEFA5 | DMBT1 | MMP9 | MYC | NFKB1 | NOS2 | RELA | S100A9 | SLC16A1 | TNF
30.13 16
Has associated exposure references.
20. Linoleic Acid Colonic Neoplasms M
11 genes: ASCL2 | BCL2 | IFNG | IL1B | MMP9 | NOS2 | PPARG | PTGS2 | RELA | TNF | VEGFA
27.30 16
21. bromodichloromethane Colonic Neoplasms M
8 genes: CCND1 | IFNG | IL1B | JUN | LEP | MYC | PCNA | TNF
24.92 14
22. 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline Colonic Neoplasms M
12 genes: BAX | BCL2 | CCND1 | CDKN1A | IL1B | JUN | KRAS | LTF | MKI67 | PTGS2 | TNF | TP53
21.95 23
23. Chenodeoxycholic Acid Colonic Neoplasms M
10 genes: BAX | CCL20 | CXCL10 | ICAM1 | IFNG | IGFBP1 | JUN | PPARG | PTGS2 | SLCO1B3
21.34 13
24. 1,2-Dimethylhydrazine Colonic Neoplasms M
7 genes: BCL2 | CTNNB1 | HES1 | IFNG | NOS2 | PTGS2 | TP53
20.96 41
25. 2-amino-3-methylimidazo(4,5-f)quinoline Colonic Neoplasms M
7 genes: APC | CDKN1A | CTNNB1 | JUN | KRAS | PTGS2 | TGFBR2
19.53 27
26. Atrazine Colonic Neoplasms M
42 genes: ACTA2 | ATP7A | BAX | BCL2 | BECN1 | BIRC5 | CBR1 | CCND1 | CDKN1A | DNMT1 | EGFR | FOLR1 | GAP43 | GUCY1A3 | IFNG | IL1B | ITGA7 | JUN | KCNH2 | LEF1 | LPL | LTF | MECOM | MKI67 | MYC | NFKB1 | PCNA | PPARG | PTGS2 | RECK | RELA | S100A4 | SERTAD1 | SLC19A1 | SLC2A1 | SLC5A8 | SOD2 | TNF | TP53 | TPM3 | TYMS | VEGFA
15.69 45
Has associated exposure references.
27. Malathion Colonic Neoplasms M
8 genes: IFNG | IL1B | MCM2 | NOS2 | PCNA | SOD2 | TP53 | TYMS
15.68 18
Has associated exposure references.
28. Cholic Acid Colonic Neoplasms M
7 genes: IL1B | LPL | PTGS2 | SLC2A1 | SLCO1B3 | SULT1A1 | VEGFA
14.73 9
29. Permethrin Colonic Neoplasms M
8 genes: BAX | ERBB2 | IFNG | IL1B | JUN | RELA | TNF | TP53
12.30 13
Has associated exposure references.
30. Azathioprine Colonic Neoplasms M
9 genes: IL1B | JUN | LTF | NOS2 | S100A9 | SOD2 | STAT3 | TNF | TP53
11.10 13
31. orlistat Colonic Neoplasms M
6 genes: ERBB2 | GCG | LEP | LPL | TNF | TNFSF10
10.61 8
32. Dinoprostone Adenomatous Polyposis Coli M
3 genes: AKT1 | PTGS2 | SOD2
9.07 2
33. diisopropanolnitrosamine Colonic Neoplasms M
3 genes: IFNG | KRAS | MKI67
8.56 9
34. Carbofuran Colonic Neoplasms M
4 genes: HSPA2 | MYC | STAT3 | TP53
7.70 8
Has associated exposure references.
35. Corn Oil Colonic Neoplasms M
4 genes: CCND1 | CDKN1A | IGFBP1 | MAP2K6
7.53 8
36. 2',3-dimethyl-4-aminobiphenyl Colonic Neoplasms M
3 genes: CCND1 | KRAS | PCNA
7.18 16
37. Fonofos Colonic Neoplasms M
11 genes: BAK1 | CYP26A1 | GSTM5 | HSPA2 | IGF2 | LEP | LGR5 | LTF | S100A4 | SLC22A1 | SLC5A8
6.87 11
Has associated exposure references.
38. Carbaryl Colonic Neoplasms M
3 genes: NFKB1 | NOS2 | RELA
6.33 5
Has associated exposure references.
39. lard Colonic Neoplasms M
2 genes: ACTA2 | PPARG
5.91 3
40. Isoniazid Colonic Neoplasms M
5 genes: A2M | BAX | BCL2 | PPARG | SOD2
5.33 7
41. Herbicides Colonic Neoplasms M
5 genes: A2M | BAX | BCL2 | IFNG | TNF
4.28 8
Has associated exposure references.
42. 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct Colonic Neoplasms M   1 gene: APC 4.16 6
43. Leukotriene B4 Adenomatous Polyposis Coli M   1 gene: AKT1 3.94 1
44. Pentagastrin Colonic Neoplasms M   1 gene: ODC1 3.61 3
45. nitrosobis(2-oxopropyl)amine Colonic Neoplasms M   1 gene: PTGS2 3.33 4
46. 2-amino-3,4-dimethylimidazo(4,5-f)quinoline Colonic Neoplasms M   1 gene: CTNNB1 3.27 13
47. Calcium, Dietary Colonic Neoplasms M   1 gene: PTGS2 2.92 4
48. Metronidazole Colonic Neoplasms M   1 gene: NOS2 2.30 3
49. 2-(2,6-dioxopiperidin-3-yl)phthalimidine Colonic Neoplasms M     1
50. 2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole Colonic Neoplasms M     3
1–50 of 6,728 results.