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Disease Colonic Neoplasms

These chemicals are associated with Colonic Neoplasms or its descendants. A chemical has either a curated association to the disease (M marker/mechanism and/or T therapeutic) or an inferred association via a curated gene interaction.

1–50 of 6,149 results.
  Chemical Disease Direct Evidence Enrichment Analysis Inference Network Inference Score References
1. 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine Colonic Neoplasms M
68 genes: A2M | ACTA2 | ACTG2 | ALOX5 | APC | ASCL2 | BAX | BCL2 | CACNA2D1 | CAR4 | CCL20 | CCND1 | CCND2 | CDKN1A | CKM | CRYAB | CTNNB1 | CXCL10 | DEFA24 | DEFA-RS1 | DMBT1 | DNMT1 | EGFR | ERBB2 | GAP43 | GSTM5 | GUCY1A3 | HMGCS2 | HSPA2 | HSPB1 | ICAM1 | ID3 | IFNG | IGFBP1 | IL1B | ITGA7 | JUN | LPL | MAOB | MCM2 | MEP1A | MMP12 | MMP7 | MMP9 | MYC | NDRG2 | NFKB1 | NOS2 | NOX1 | NOX4 | PCNA | PCP4 | PLCB1 | PTGS2 | RATNP-3B | RELA | RHOJ | RNF34 | S100A9 | SERPINB5 | SH3KBP1 | SLC22A1 | SULT1A1 | TAGLN | TCF19 | TNF | TP53 | TPM3
161.75 57
2. Azoxymethane Colonic Neoplasms M
25 genes: APC | BAX | BCL2 | CCND1 | CDKN1A | FOLR1 | IFNG | IL1B | KRAS | LEP | MKI67 | MMP7 | MYC | NFKB1 | NOS2 | PCNA | PTGS2 | RELA | SLC19A1 | SRC | STAT3 | TNF | TNFSF10 | TP53 | TYMS
81.80 69
3. Diethylnitrosamine Colonic Neoplasms M
73 genes: A2M | ACTA2 | ACTG2 | APC | BAX | BCL2 | BIRC5 | CACNA2D1 | CAR4 | CBR1 | CCND1 | CDKN1A | CRYAB | CTNNB1 | CYP26A1 | DMBT1 | DNMT1 | DPYD | EGFR | GAST | GSTM5 | HMGCS2 | HSPA2 | HSPB1 | ICAM1 | ID3 | IFNG | IGF2 | IGFBP1 | IL1B | JUN | KRAS | LPL | MAOB | MCM2 | MEP1A | MKI67 | MMP12 | MMP9 | MTHFR | MYC | NDRG2 | NFKB1 | NOS2 | NOTCH1 | NOX4 | ODC1 | PCNA | PCP4 | PLCB1 | PPARG | PROM1 | PTGS2 | RELA | RFC1 | S100A4 | S100A9 | SERPINB5 | SLC16A1 | SPARC | SRC | STAT3 | SULT1A1 | TAGLN | TCF19 | TGFBR2 | TNF | TNFSF10 | TP53 | TPM3 | TYMS | UMPS | VEGFA
67.87 60
4. Hydrogen Peroxide Colonic Neoplasms M
68 genes: ACTA2 | ACTG2 | ALOX5 | APC | ATP7A | BAK1 | BAX | BCL2 | BECN1 | BIRC5 | CCL20 | CCND2 | CDKN1A | CKM | CTNNB1 | DNMT1 | EGFR | ERBB2 | FOLR1 | FZD2 | GUCY1A3 | HES1 | HSPA2 | HSPB1 | ICAM1 | ID3 | IFNG | IGFBP1 | IL1B | ITGA7 | JUN | KCNH2 | KRAS | LEP | LGR5 | LTF | MAP2K6 | MEP1A | MMP12 | MMP7 | MMP9 | MYC | NDRG2 | NFKB1 | NOS2 | ODC1 | PARP4 | PCNA | PPARG | PTGS2 | RECK | RELA | S100A4 | SERPINB5 | SH3KBP1 | SLC16A1 | SLC19A1 | SLC2A1 | SLC5A8 | SRC | STAT3 | SULT1A1 | TGFBR2 | TNF | TP53 | TPM3 | VEGFA | XAF1
53.07 61
5. Dextran Sulfate Colonic Neoplasms M
21 genes: APC | BAX | CTNNB1 | GAST | ICAM1 | IFNG | IL1B | LEP | MKI67 | MMP9 | NFKB1 | NOS2 | PCNA | PPARG | PTGS2 | RELA | SLC2A1 | STAT3 | TNF | TYMS | VEGFA
51.16 41
6. Deoxycholic Acid Colonic Neoplasms M
19 genes: BAX | BCL2 | CCL20 | CCND1 | CXCL10 | EGFR | ICAM1 | IFNG | IL1B | LEP | LPL | NFKB1 | PPARG | PTGS2 | RELA | SERPINB5 | SLC22A1 | TNF | TP53
46.31 23
7. Sulfasalazine Colonic Neoplasms M
23 genes: ACTA2 | BAX | BCL2 | CCND1 | CDKN1A | CTNNB1 | EGFR | ICAM1 | IFNG | IL1B | IL1RN | MMP9 | MTHFR | NFKB1 | NOS2 | ODC1 | PCNA | PPARG | PTGS2 | RELA | TNF | TPM3 | TYMP
46.22 33
8. Nicotine Colonic Neoplasms M
39 genes: ALOX5 | BAX | BCL2 | BIRC5 | CACNA2D1 | CCND1 | CCND2 | CDKN1A | CRYAB | CYP26A1 | EGFR | FOLR1 | ICAM1 | ID3 | IL1B | JUN | KCNH2 | LEP | LPL | LTF | MAP2K6 | MMP7 | MMP9 | MYC | NFKB1 | NOS2 | NOX4 | PARK2 | PARP4 | PCNA | PTGS2 | RELA | SH3KBP1 | SLC19A1 | SRC | STAT3 | TNF | TP53 | VEGFA
44.58 36
9. Methylnitrosourea Colonic Neoplasms M
23 genes: APC | BAX | BCL2 | CBR1 | CCND1 | CDKN1A | CTNNB1 | DMBT1 | EGFR | IFNG | IL1B | JUN | KRAS | LEP | MYC | NOS2 | PCNA | PPARG | RELA | SRC | TNF | TP53 | VEGFA
44.56 38
10. 4-hydroxy-2-nonenal Colonic Neoplasms M
32 genes: ALOX5 | APC | BAX | BIRC5 | CCND1 | CCND2 | CDKN1A | CTNNB1 | CXCL10 | ERBB2 | HSPA2 | ICAM1 | IFNG | IL1B | IL1RN | ITGA7 | JUN | MKI67 | MMP9 | MYC | NFKB1 | NOS2 | NOTCH1 | PCNA | RELA | SERPINB5 | SRC | STAT3 | TNF | TP53 | VEGFA | XAF1
40.36 36
11. Iron Colonic Neoplasms M
25 genes: ATP7A | BCL2 | CCND1 | CDKN1A | DNMT1 | HMGCS2 | HSPB1 | ICAM1 | IFNG | IL1B | JUN | LEP | LTF | MAP2K6 | MYC | NOS2 | ODC1 | PCNA | PPARG | PTGS2 | S100A9 | SRC | TNF | TNFSF10 | TP53
38.55 31
12. Plant Preparations Colonic Neoplasms M
19 genes: ACTA2 | CCND1 | CDKN1A | CTNNB1 | CXCL10 | GCG | ICAM1 | IFNG | IL1B | JUN | LEP | LPL | MYC | NOS2 | ODC1 | PTGS2 | RELA | SULT1A1 | TNF
37.52 26
13. Dietary Fats Colonic Neoplasms M
55 genes: A2M | ACTA2 | ACTG2 | APC | CAR4 | CCND1 | CDKN1A | CTNNB1 | DNMT1 | DPYD | EGFR | GCG | HES1 | HMGCS2 | HSPA2 | HSPB1 | ICAM1 | ID3 | IGFBP1 | IL1B | IL1RN | JUN | LEP | LPL | MAOB | MAP2K6 | MCM2 | MKI67 | MMP12 | MMP9 | MYC | NFKB1 | NOS2 | NOX4 | PCNA | PPARG | PROM1 | PTGS2 | RECK | RELA | S100A4 | S100A9 | SERTAD1 | SH3KBP1 | SLC16A1 | SLC2A1 | SPARC | STAT3 | SULT1A1 | TAGLN | TGFBR2 | TNF | TNFSF10 | UMPS | VEGFA
33.42 45
14. Lithocholic Acid Colonic Neoplasms M
18 genes: BAK1 | BAX | CTNNB1 | CYP26A1 | GCG | HMGCS2 | HSPB1 | ICAM1 | IL1B | JUN | LPL | MMP9 | PTGS2 | RELA | SLC2A1 | TGFBR2 | TNF | VEGFA
31.60 24
15. Butylated Hydroxytoluene Colonic Neoplasms M
16 genes: ACTA2 | ALOX5 | CCND1 | CTNNB1 | KRAS | LEF1 | LEP | NFKB1 | PCNA | PPARG | PTGS2 | RELA | SLC2A1 | TNF | TP53 | VEGFA
29.73 31
16. Caffeine Colonic Neoplasms M
24 genes: BAX | CCND1 | CDKN1A | CTNNB1 | GAST | HSPB1 | ID3 | IGFBP1 | JUN | LEP | LPL | MMP7 | MYC | NFKB1 | NOS2 | PLCB1 | PPARG | PTGS2 | RELA | SLC16A1 | TNF | TP53 | TYMS | VEGFA
29.34 34
17. 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline Colonic Neoplasms M
12 genes: BAX | BCL2 | CCND1 | CDKN1A | IL1B | JUN | KRAS | LTF | MKI67 | PTGS2 | TNF | TP53
21.73 23
18. 1,2-Dimethylhydrazine Colonic Neoplasms M
7 genes: BCL2 | CTNNB1 | HES1 | IFNG | NOS2 | PTGS2 | TP53
20.83 41
19. 2-amino-3-methylimidazo(4,5-f)quinoline Colonic Neoplasms M
7 genes: APC | CDKN1A | CTNNB1 | JUN | KRAS | PTGS2 | TGFBR2
19.39 27
20. bromodichloromethane Colonic Neoplasms M
6 genes: CCND1 | JUN | LEP | MYC | PCNA | TNF
18.61 12
21. Cholic Acid Colonic Neoplasms M
6 genes: IL1B | LPL | PTGS2 | SLC2A1 | SULT1A1 | VEGFA
12.03 8
22. orlistat Colonic Neoplasms M
6 genes: ERBB2 | GCG | LEP | LPL | TNF | TNFSF10
10.75 8
23. Dinoprostone Adenomatous Polyposis Coli M
3 genes: AKT1 | PTGS2 | SOD2
8.91 2
24. diisopropanolnitrosamine Colonic Neoplasms M
3 genes: IFNG | KRAS | MKI67
8.51 9
25. Corn Oil Colonic Neoplasms M
4 genes: CCND1 | CDKN1A | IGFBP1 | MAP2K6
7.45 8
26. 2',3-dimethyl-4-aminobiphenyl Colonic Neoplasms M
3 genes: CCND1 | KRAS | PCNA
7.12 16
27. Azathioprine Colonic Neoplasms M
6 genes: JUN | LTF | NOS2 | STAT3 | TNF | TP53
6.08 10
28. Isoniazid Colonic Neoplasms M
4 genes: A2M | BAX | BCL2 | PPARG
4.72 6
29. lard Colonic Neoplasms M   1 gene: ACTA2 4.17 2
30. 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct Colonic Neoplasms M   1 gene: APC 4.13 6
31. Leukotriene B4 Adenomatous Polyposis Coli M   1 gene: AKT1 3.89 1
32. Pentagastrin Colonic Neoplasms M   1 gene: ODC1 3.58 3
33. nitrosobis(2-oxopropyl)amine Colonic Neoplasms M   1 gene: PTGS2 3.30 4
34. 2-amino-3,4-dimethylimidazo(4,5-f)quinoline Colonic Neoplasms M   1 gene: CTNNB1 3.26 13
35. Calcium, Dietary Colonic Neoplasms M   1 gene: PTGS2 2.90 4
36. Metronidazole Colonic Neoplasms M   1 gene: NOS2 2.28 3
37. 2-(2,6-dioxopiperidin-3-yl)phthalimidine Colonic Neoplasms M     1
38. 2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole Colonic Neoplasms M     3
39. 2-hexenal Colonic Neoplasms M     1
40. Adnab-9 Colonic Neoplasms M     2
41. C.I. Acid Red 114 Colonic Neoplasms M     1
42. Dimethylhydrazines Colonic Neoplasms M     3
43. FANFT Colonic Neoplasms M     1
44. N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine Colonic Neoplasms M     1
45. N-ethyl-N-hydroxyethylnitrosamine Colonic Neoplasms M     1
46. Fluorouracil Colonic Neoplasms M T
59 genes: ACTG2 | BAK1 | BAX | BCL2 | BECN1 | BIRC5 | CCND1 | CCND2 | CDKN1A | DPYD | EGFR | ERBB2 | FOLR1 | FZD2 | GAST | HES1 | HSPA2 | HSPB1 | ID3 | IFNG | IL1B | IL1RN | JUN | KRAS | MCM2 | MKI67 | MMP9 | MTHFR | MYC | NFKB1 | NOS2 | ODC1 | PCNA | PPARG | PROM1 | PTGS2 | RELA | RNF34 | S100A4 | SERPINB5 | SERTAD1 | SLC16A1 | SLC2A1 | SPARC | SRC | STAT3 | TAGLN | TCF19 | TCF7L2 | TNF | TNFRSF10A | TNFSF10 | TP53 | TYMP | TYMS | UMPS | VEGFA | WT1 | XAF1
73.34 91
47. troglitazone Colonic Neoplasms M T
51 genes: ACTA2 | ALOX5 | AXIN2 | BAX | BCL2 | BIRC5 | CCL20 | CCND1 | CCND2 | CDKN1A | CRYAB | CTNNB1 | CXCL10 | CYP26A1 | DNMT1 | FBP1 | GCG | HMGCS2 | HSPA2 | ICAM1 | ID3 | IFNG | IGFBP1 | IL1B | JUN | LEP | LPL | MAP2K6 | MCM2 | MKI67 | MMP9 | MYC | NFKB1 | NOS2 | ODC1 | PCNA | PPARG | PROM1 | PTGS2 | RELA | SERPINB5 | SLC2A1 | SULT1A1 | TAGLN | TNF | TNFRSF10A | TNFSF10 | TP53 | TYMS | UMPS | VEGFA
65.21 52
48. Aspirin Colonic Neoplasms M T
39 genes: BAK1 | BAX | BCL2 | BIRC5 | CCND1 | CDKN1A | CTNNB1 | DEFA5 | EGFR | ERBB2 | GAST | HSPB1 | ICAM1 | IFNG | IGF2 | IL1B | IL1RN | JUN | LEP | MMP7 | MMP9 | MYC | NFKB1 | NOS2 | NOX4 | ODC1 | PPARG | PTGS2 | RELA | S100A4 | SERPINB5 | SLC16A1 | SPARC | STAT3 | TNF | TNFSF10 | TP53 | TYMP | VEGFA
50.21 47
49. Curcumin Colonic Neoplasms T
52 genes: ACTA2 | ALOX5 | APC | BAK1 | BAX | BCL2 | BIRC5 | CCND1 | CDKN1A | CKM | CRYAB | CTNNB1 | EGFR | ERBB2 | HES1 | HSPB1 | ICAM1 | ID3 | IFNG | IL1B | JUN | KRAS | MCM2 | MKI67 | MMP7 | MMP9 | MYC | NFKB1 | NOS2 | NOTCH1 | ODC1 | PCNA | PPARG | PTGS2 | RELA | S100A9 | SERPINB5 | SLC16A1 | SLC2A1 | SPARC | SRC | STAT3 | TCF7L2 | TGFBR2 | TNF | TNFRSF10A | TNFSF10 | TP53 | TYMP | VEGFA | WT1 | XAF1
90.21 57
50. decitabine Colonic Neoplasms T
53 genes: ACTA2 | APC | BAK1 | BAX | BCL2 | BECN1 | BIRC5 | CCL20 | CCND1 | CDKN1A | CTNNB1 | CXCL10 | DNMT1 | DPYD | EGFR | FBP1 | GSTM5 | HSPB1 | ICAM1 | ID3 | IFNG | IGF2 | JUN | LEF1 | LEP | MKI67 | MMP9 | MYC | NFKB1 | NOTCH1 | PCNA | PPARG | PROM1 | PTGS2 | RECK | RELA | S100A4 | S100A9 | SERPINB5 | SLC16A1 | SLC19A1 | SLC5A8 | SPARC | SRC | STAT3 | TGFBR2 | TNF | TNFRSF10A | TNFSF10 | TP53 | TPM3 | VEGFA | XAF1
74.98 53
1–50 of 6,149 results.