Colonic Neoplasms - Chemicals

These chemicals are associated with Colonic Neoplasms or its descendants. A chemical has either a curated association to the disease (M marker/mechanism and/or T therapeutic) or an inferred association via a curated gene interaction.

1–50 of 5,824 results.

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	Chemical	Disease	Direct Evidence	Inference Network	Inference Score	References
1.	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	Colonic Neoplasms	M	67 genes: A2M \| ACTA2 \| ACTG2 \| ALOX5 \| APC \| ASCL2 \| BAX \| BCL2 \| CACNA2D1 \| CAR4 \| CCL20 \| CCND1 \| CCND2 \| CDKN1A \| CKM \| CRYAB \| CTNNB1 \| CXCL10 \| DEFA24 \| DEFA-RS1 \| DMBT1 \| DNMT1 \| EGFR \| ERBB2 \| GAP43 \| GSTM5 \| GUCY1A3 \| HMGCS2 \| HSPA2 \| HSPB1 \| ICAM1 \| ID3 \| IFNG \| IGFBP1 \| IL1B \| ITGA7 \| JUN \| LPL \| MAOB \| MEP1A \| MMP12 \| MMP7 \| MMP9 \| MYC \| NDRG2 \| NFKB1 \| NOS2 \| NOX1 \| NOX4 \| PCNA \| PCP4 \| PLCB1 \| PTGS2 \| RATNP-3B \| RELA \| RHOJ \| RNF34 \| S100A9 \| SERPINB5 \| SH3KBP1 \| SLC22A1 \| SULT1A1 \| TAGLN \| TCF19 \| TNF \| TP53 \| TPM3	158.85	55
2.	Azoxymethane	Colonic Neoplasms	M	25 genes: APC \| BAX \| BCL2 \| CCND1 \| CDKN1A \| FOLR1 \| IFNG \| IL1B \| KRAS \| LEP \| MKI67 \| MMP7 \| MYC \| NFKB1 \| NOS2 \| PCNA \| PTGS2 \| RELA \| SLC19A1 \| SRC \| STAT3 \| TNF \| TNFSF10 \| TP53 \| TYMS	81.84	68
3.	Diethylnitrosamine	Colonic Neoplasms	M	70 genes: A2M \| ACTA2 \| ACTG2 \| APC \| BAX \| BCL2 \| BIRC5 \| CACNA2D1 \| CAR4 \| CBR1 \| CCND1 \| CDKN1A \| CRYAB \| CTNNB1 \| CYP26A1 \| DMBT1 \| DNMT1 \| DPYD \| EGFR \| GAST \| GSTM5 \| HMGCS2 \| HSPA2 \| HSPB1 \| ID3 \| IFNG \| IGF2 \| IGFBP1 \| IL1B \| JUN \| KRAS \| LPL \| MAOB \| MEP1A \| MKI67 \| MMP9 \| MTHFR \| MYC \| NDRG2 \| NFKB1 \| NOS2 \| NOTCH1 \| NOX4 \| ODC1 \| PCNA \| PCP4 \| PLCB1 \| PPARG \| PROM1 \| PTGS2 \| RELA \| RFC1 \| S100A4 \| S100A9 \| SERPINB5 \| SLC16A1 \| SPARC \| SRC \| STAT3 \| SULT1A1 \| TAGLN \| TCF19 \| TGFBR2 \| TNF \| TNFSF10 \| TP53 \| TPM3 \| TYMS \| UMPS \| VEGFA	65.25	57
4.	Dextran Sulfate	Colonic Neoplasms	M	20 genes: APC \| CTNNB1 \| GAST \| ICAM1 \| IFNG \| IL1B \| LEP \| MKI67 \| MMP9 \| NFKB1 \| NOS2 \| PCNA \| PPARG \| PTGS2 \| RELA \| SLC2A1 \| STAT3 \| TNF \| TYMS \| VEGFA	59.68	41
5.	Hydrogen Peroxide	Colonic Neoplasms	M	67 genes: ACTA2 \| ACTG2 \| ALOX5 \| APC \| ATP7A \| BAK1 \| BAX \| BCL2 \| BECN1 \| BIRC5 \| CCL20 \| CCND2 \| CDKN1A \| CKM \| CTNNB1 \| DNMT1 \| EGFR \| ERBB2 \| FOLR1 \| FZD2 \| GUCY1A3 \| HES1 \| HSPA2 \| HSPB1 \| ICAM1 \| ID3 \| IFNG \| IGFBP1 \| IL1B \| ITGA7 \| JUN \| KCNH2 \| KRAS \| LEP \| LTF \| MAP2K6 \| MEP1A \| MMP12 \| MMP7 \| MMP9 \| MYC \| NDRG2 \| NFKB1 \| NOS2 \| ODC1 \| PARP4 \| PCNA \| PPARG \| PTGS2 \| RECK \| RELA \| S100A4 \| SERPINB5 \| SH3KBP1 \| SLC16A1 \| SLC19A1 \| SLC2A1 \| SLC5A8 \| SRC \| STAT3 \| SULT1A1 \| TGFBR2 \| TNF \| TP53 \| TPM3 \| VEGFA \| XAF1	53.66	61
6.	Sulfasalazine	Colonic Neoplasms	M	23 genes: ACTA2 \| BAX \| BCL2 \| CCND1 \| CDKN1A \| CTNNB1 \| EGFR \| ICAM1 \| IFNG \| IL1B \| IL1RN \| MMP9 \| MTHFR \| NFKB1 \| NOS2 \| ODC1 \| PCNA \| PPARG \| PTGS2 \| RELA \| TNF \| TPM3 \| TYMP	46.24	33
7.	Methylnitrosourea	Colonic Neoplasms	M	23 genes: APC \| BAX \| BCL2 \| CBR1 \| CCND1 \| CDKN1A \| CTNNB1 \| DMBT1 \| EGFR \| IFNG \| IL1B \| JUN \| KRAS \| LEP \| MYC \| NOS2 \| PCNA \| PPARG \| RELA \| SRC \| TNF \| TP53 \| VEGFA	45.51	38
8.	4-hydroxy-2-nonenal	Colonic Neoplasms	M	32 genes: ALOX5 \| APC \| BAX \| BIRC5 \| CCND1 \| CCND2 \| CDKN1A \| CTNNB1 \| CXCL10 \| ERBB2 \| HSPA2 \| ICAM1 \| IFNG \| IL1B \| IL1RN \| ITGA7 \| JUN \| MKI67 \| MMP9 \| MYC \| NFKB1 \| NOS2 \| NOTCH1 \| PCNA \| RELA \| SERPINB5 \| SRC \| STAT3 \| TNF \| TP53 \| VEGFA \| XAF1	40.51	36
9.	Nicotine	Colonic Neoplasms	M	35 genes: ALOX5 \| BAX \| BCL2 \| BIRC5 \| CACNA2D1 \| CCND1 \| CCND2 \| CDKN1A \| CRYAB \| CYP26A1 \| EGFR \| FOLR1 \| ICAM1 \| ID3 \| IL1B \| JUN \| KCNH2 \| LPL \| MAP2K6 \| MMP7 \| MMP9 \| MYC \| NFKB1 \| NOS2 \| NOX4 \| PARK2 \| PCNA \| PTGS2 \| RELA \| SLC19A1 \| SRC \| STAT3 \| TNF \| TP53 \| VEGFA	40.47	33
10.	Iron	Colonic Neoplasms	M	24 genes: ATP7A \| BCL2 \| CCND1 \| CDKN1A \| DNMT1 \| HMGCS2 \| HSPB1 \| ICAM1 \| IFNG \| IL1B \| JUN \| LEP \| LTF \| MAP2K6 \| MYC \| NOS2 \| ODC1 \| PCNA \| PPARG \| PTGS2 \| S100A9 \| TNF \| TNFSF10 \| TP53	36.39	30
11.	Deoxycholic Acid	Colonic Neoplasms	M	15 genes: BAX \| BCL2 \| CCL20 \| CCND1 \| CXCL10 \| EGFR \| ICAM1 \| IFNG \| LPL \| NFKB1 \| PTGS2 \| RELA \| SERPINB5 \| SLC22A1 \| TP53	36.38	19
12.	Plant Preparations	Colonic Neoplasms	M	17 genes: ACTA2 \| CDKN1A \| CXCL10 \| GCG \| ICAM1 \| IFNG \| IL1B \| JUN \| LEP \| LPL \| MYC \| NOS2 \| ODC1 \| PTGS2 \| RELA \| SULT1A1 \| TNF	32.95	19
13.	Dietary Fats	Colonic Neoplasms	M	54 genes: A2M \| ACTA2 \| ACTG2 \| APC \| CAR4 \| CCND1 \| CDKN1A \| CTNNB1 \| DNMT1 \| DPYD \| EGFR \| GCG \| HES1 \| HMGCS2 \| HSPA2 \| HSPB1 \| ICAM1 \| ID3 \| IGFBP1 \| IL1B \| IL1RN \| JUN \| LEP \| LPL \| MAOB \| MAP2K6 \| MKI67 \| MMP12 \| MMP9 \| MYC \| NFKB1 \| NOS2 \| NOX4 \| PCNA \| PPARG \| PROM1 \| PTGS2 \| RECK \| RELA \| S100A4 \| S100A9 \| SERTAD1 \| SH3KBP1 \| SLC16A1 \| SLC2A1 \| SPARC \| STAT3 \| SULT1A1 \| TAGLN \| TGFBR2 \| TNF \| TNFSF10 \| UMPS \| VEGFA	32.66	44
14.	Butylated Hydroxytoluene	Colonic Neoplasms	M	16 genes: ACTA2 \| ALOX5 \| CCND1 \| CTNNB1 \| KRAS \| LEF1 \| LEP \| NFKB1 \| PCNA \| PPARG \| PTGS2 \| RELA \| SLC2A1 \| TNF \| TP53 \| VEGFA	29.67	31
15.	Caffeine	Colonic Neoplasms	M	21 genes: BAX \| CCND1 \| CDKN1A \| CTNNB1 \| GAST \| HSPB1 \| ID3 \| IGFBP1 \| JUN \| MMP7 \| MYC \| NFKB1 \| NOS2 \| PLCB1 \| PTGS2 \| RELA \| SLC16A1 \| TNF \| TP53 \| TYMS \| VEGFA	25.10	32
16.	1,2-Dimethylhydrazine	Colonic Neoplasms	M	7 genes: BCL2 \| CTNNB1 \| HES1 \| IFNG \| NOS2 \| PTGS2 \| TP53	21.03	40
17.	2-amino-3-methylimidazo(4,5-f)quinoline	Colonic Neoplasms	M	7 genes: APC \| CDKN1A \| CTNNB1 \| JUN \| KRAS \| PTGS2 \| TGFBR2	19.39	27
18.	Cholic Acid	Colonic Neoplasms	M	6 genes: IL1B \| LPL \| PTGS2 \| SLC2A1 \| SULT1A1 \| VEGFA	13.74	8
19.	orlistat	Colonic Neoplasms	M	6 genes: ERBB2 \| GCG \| LEP \| LPL \| TNF \| TNFSF10	10.75	8
20.	Dinoprostone	Adenomatous Polyposis Coli	M	3 genes: AKT1 \| PTGS2 \| SOD2	8.92	2
21.	diisopropanolnitrosamine	Colonic Neoplasms	M	3 genes: IFNG \| KRAS \| MKI67	8.51	9
22.	2',3-dimethyl-4-aminobiphenyl	Colonic Neoplasms	M	3 genes: CCND1 \| KRAS \| PCNA	7.12	16
23.	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	Colonic Neoplasms	M	5 genes: KRAS \| LTF \| MKI67 \| PTGS2 \| TP53	6.72	13
24.	bromodichloromethane	Colonic Neoplasms	M	2 genes: MYC \| PCNA	6.18	7
25.	Azathioprine	Colonic Neoplasms	M	5 genes: LTF \| NOS2 \| STAT3 \| TNF \| TP53	4.86	8
26.	2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct	Colonic Neoplasms	M	1 gene: APC	4.12	6
27.	Isoniazid	Colonic Neoplasms	M	3 genes: A2M \| BAX \| BCL2	3.67	5
28.	Pentagastrin	Colonic Neoplasms	M	1 gene: ODC1	3.58	3
29.	nitrosobis(2-oxopropyl)amine	Colonic Neoplasms	M	1 gene: PTGS2	3.31	4
30.	2-amino-3,4-dimethylimidazo(4,5-f)quinoline	Colonic Neoplasms	M	1 gene: CTNNB1	3.28	13
31.	Calcium, Dietary	Colonic Neoplasms	M	1 gene: PTGS2	2.91	4
32.	Metronidazole	Colonic Neoplasms	M	1 gene: NOS2	2.30	3
33.	Leukotriene B4	Adenomatous Polyposis Coli	M			1
34.	2-(2,6-dioxopiperidin-3-yl)phthalimidine	Colonic Neoplasms	M			1
35.	2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole	Colonic Neoplasms	M			3
36.	2-hexenal	Colonic Neoplasms	M			1
37.	Adnab-9	Colonic Neoplasms	M			2
38.	C.I. Acid Red 114	Colonic Neoplasms	M			1
39.	Dimethylhydrazines	Colonic Neoplasms	M			3
40.	N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	Colonic Neoplasms	M			1
41.	N-ethyl-N-hydroxyethylnitrosamine	Colonic Neoplasms	M			1
42.	Fluorouracil	Colonic Neoplasms	M T	57 genes: ACTG2 \| BAK1 \| BAX \| BCL2 \| BECN1 \| BIRC5 \| CCND1 \| CCND2 \| CDKN1A \| DPYD \| EGFR \| ERBB2 \| FOLR1 \| FZD2 \| GAST \| HES1 \| HSPA2 \| HSPB1 \| ID3 \| IFNG \| IL1B \| IL1RN \| JUN \| KRAS \| MKI67 \| MMP9 \| MTHFR \| MYC \| NFKB1 \| NOS2 \| ODC1 \| PCNA \| PPARG \| PROM1 \| PTGS2 \| RELA \| RNF34 \| S100A4 \| SERPINB5 \| SERTAD1 \| SLC16A1 \| SLC2A1 \| SPARC \| SRC \| STAT3 \| TAGLN \| TCF19 \| TCF7L2 \| TNF \| TNFRSF10A \| TNFSF10 \| TP53 \| TYMP \| TYMS \| UMPS \| VEGFA \| XAF1	69.21	89
43.	troglitazone	Colonic Neoplasms	M T	50 genes: ACTA2 \| ALOX5 \| AXIN2 \| BAX \| BCL2 \| BIRC5 \| CCL20 \| CCND1 \| CCND2 \| CDKN1A \| CRYAB \| CTNNB1 \| CXCL10 \| CYP26A1 \| DNMT1 \| FBP1 \| GCG \| HMGCS2 \| HSPA2 \| ICAM1 \| ID3 \| IFNG \| IGFBP1 \| IL1B \| JUN \| LEP \| LPL \| MAP2K6 \| MKI67 \| MMP9 \| MYC \| NFKB1 \| NOS2 \| ODC1 \| PCNA \| PPARG \| PROM1 \| PTGS2 \| RELA \| SERPINB5 \| SLC2A1 \| SULT1A1 \| TAGLN \| TNF \| TNFRSF10A \| TNFSF10 \| TP53 \| TYMS \| UMPS \| VEGFA	63.21	51
44.	Aspirin	Colonic Neoplasms	M T	39 genes: BAK1 \| BAX \| BCL2 \| BIRC5 \| CCND1 \| CDKN1A \| CTNNB1 \| DEFA5 \| EGFR \| ERBB2 \| GAST \| HSPB1 \| ICAM1 \| IFNG \| IGF2 \| IL1B \| IL1RN \| JUN \| LEP \| MMP7 \| MMP9 \| MYC \| NFKB1 \| NOS2 \| NOX4 \| ODC1 \| PPARG \| PTGS2 \| RELA \| S100A4 \| SERPINB5 \| SLC16A1 \| SPARC \| STAT3 \| TNF \| TNFSF10 \| TP53 \| TYMP \| VEGFA	50.50	47
45.	Curcumin	Colonic Neoplasms	T	50 genes: ACTA2 \| ALOX5 \| APC \| BAK1 \| BAX \| BCL2 \| BIRC5 \| CCND1 \| CDKN1A \| CKM \| CRYAB \| CTNNB1 \| EGFR \| ERBB2 \| HES1 \| HSPB1 \| ICAM1 \| ID3 \| IFNG \| IL1B \| JUN \| KRAS \| MKI67 \| MMP7 \| MMP9 \| MYC \| NFKB1 \| NOS2 \| NOTCH1 \| ODC1 \| PCNA \| PPARG \| PTGS2 \| RELA \| S100A9 \| SERPINB5 \| SLC16A1 \| SLC2A1 \| SPARC \| SRC \| STAT3 \| TCF7L2 \| TGFBR2 \| TNF \| TNFRSF10A \| TNFSF10 \| TP53 \| TYMP \| VEGFA \| XAF1	86.11	55
46.	decitabine	Colonic Neoplasms	T	53 genes: ACTA2 \| APC \| BAK1 \| BAX \| BCL2 \| BECN1 \| BIRC5 \| CCL20 \| CCND1 \| CDKN1A \| CTNNB1 \| CXCL10 \| DNMT1 \| DPYD \| EGFR \| FBP1 \| GSTM5 \| HSPB1 \| ICAM1 \| ID3 \| IFNG \| IGF2 \| JUN \| LEF1 \| LEP \| MKI67 \| MMP9 \| MYC \| NFKB1 \| NOTCH1 \| PCNA \| PPARG \| PROM1 \| PTGS2 \| RECK \| RELA \| S100A4 \| S100A9 \| SERPINB5 \| SLC16A1 \| SLC19A1 \| SLC5A8 \| SPARC \| SRC \| STAT3 \| TGFBR2 \| TNF \| TNFRSF10A \| TNFSF10 \| TP53 \| TPM3 \| VEGFA \| XAF1	75.24	53
47.	Dexamethasone	Colonic Neoplasms	T	59 genes: A2M \| ACTA2 \| ACTG2 \| ALOX5 \| BAK1 \| BAX \| BCL2 \| BIRC5 \| CACNA2D1 \| CCND1 \| CCND2 \| CDKN1A \| CRYAB \| CTNNB1 \| CXCL10 \| EGFR \| FZD2 \| GCG \| GSTM5 \| HES1 \| HMGCS2 \| HSPB1 \| ICAM1 \| IFNG \| IGF2 \| IGFBP1 \| IL1B \| IL1RN \| JUN \| LEF1 \| LEP \| LPL \| MAOB \| MAP2K6 \| MKI67 \| MMP12 \| MMP9 \| MYC \| NFKB1 \| NOS2 \| NOTCH1 \| ODC1 \| PCNA \| PCP4 \| PPARG \| PTGS2 \| RELA \| S100A9 \| SLC22A1 \| SRC \| STAT3 \| SULT1A1 \| TAGLN \| TGFBR2 \| TNF \| TNFSF10 \| TP53 \| TYMP \| VEGFA	72.99	42
48.	Doxorubicin	Colonic Neoplasms	T	58 genes: ACTA2 \| ATP7A \| BAK1 \| BAX \| BCL2 \| BECN1 \| BIRC5 \| CBR1 \| CCL20 \| CCND1 \| CCND2 \| CDKN1A \| CKM \| CRYAB \| CTNNB1 \| DNMT1 \| EGFR \| ERBB2 \| FOLR1 \| HSPA2 \| HSPB1 \| ID3 \| IFNG \| IL1B \| IL1RN \| JUN \| KCNH2 \| MAP2K6 \| MKI67 \| MMP12 \| MMP9 \| MYC \| NFKB1 \| NOS2 \| NOX1 \| NOX4 \| ODC1 \| PCNA \| PPARG \| PTGS2 \| RELA \| RHOJ \| S100A9 \| SLC22A1 \| SLC2A1 \| SPARC \| STAT3 \| SULT1A1 \| TAGLN \| TCF7L2 \| TGFBR2 \| TNF \| TNFRSF10A \| TNFSF10 \| TP53 \| TYMP \| TYMS \| VEGFA	72.83	51
49.	Indomethacin	Colonic Neoplasms	T	44 genes: ALOX5 \| APC \| BAK1 \| BAX \| BCL2 \| BIRC5 \| CBR1 \| CCND1 \| CCND2 \| CDKN1A \| CRYAB \| CTNNB1 \| CXCL10 \| EGFR \| GCG \| HMGCS2 \| HSPB1 \| ICAM1 \| IFNG \| IL1B \| IL1RN \| JUN \| LEP \| LPL \| MKI67 \| MMP9 \| MYC \| NFKB1 \| NOS2 \| PARK2 \| PCNA \| PPARG \| PTGS2 \| RELA \| SLC16A1 \| SLC19A1 \| SLC22A1 \| SPARC \| STAT3 \| SULT1A1 \| TCF7L2 \| TNF \| TP53 \| VEGFA	71.59	51
50.	Acetylcysteine	Colonic Neoplasms	T	44 genes: ACTA2 \| BAK1 \| BAX \| BCL2 \| BECN1 \| BIRC5 \| CCL20 \| CCND1 \| CCND2 \| CDKN1A \| CKM \| CRYAB \| CTNNB1 \| EGFR \| GAP43 \| HSPB1 \| ICAM1 \| IFNG \| IGFBP1 \| IL1B \| JUN \| KRAS \| MAP2K6 \| MMP7 \| MMP9 \| MYC \| NFKB1 \| NOS2 \| NOX1 \| NOX4 \| PCNA \| PPARG \| PTGS2 \| RELA \| S100A4 \| SRC \| STAT3 \| TGFBR2 \| TNF \| TNFRSF10A \| TNFSF10 \| TP53 \| TYMP \| VEGFA	71.48	43

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