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Disease Colorectal Neoplasms, Hereditary Nonpolyposis

Name Colorectal Neoplasms, Hereditary Nonpolyposis
Synonyms Colon Cancer, Familial Nonpolyposis | Colorectal Cancer Hereditary Nonpolyposis | Familial Nonpolyposis Colon Cancer | Hereditary Nonpolyposis Colon Cancer | Hereditary Nonpolyposis Colorectal Cancer | Hereditary Nonpolyposis Colorectal Neoplasms | Lynch Cancer Family Syndrome I | Lynch Syndrome | Lynch Syndrome I | Syndrome, Lynch
Definition A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.
Categories Cancer | Digestive system disease | Genetic disease (inborn) | Metabolic disease
MeSH® ID D003123
External Links

Top ↑ Ancestors

1. DiseasesNeoplasms Has associated chemicals Has associated genes Has associated exposure references Neoplasms by Site Has associated chemicals Has associated genes Has associated exposure references Digestive System Neoplasms Has associated chemicals Has associated genes Has associated exposure references Gastrointestinal Neoplasms Has associated chemicals Has associated genes Has associated exposure references Intestinal Neoplasms Has associated chemicals Has associated genes Has associated exposure references Colorectal Neoplasms Has associated chemicals Has associated genes Has associated exposure references Colorectal Neoplasms, Hereditary Nonpolyposis Has associated chemicals Has associated genes
2. DiseasesNeoplasms Has associated chemicals Has associated genes Has associated exposure references Neoplastic Syndromes, Hereditary Has associated chemicals Has associated genes Has associated exposure references Colorectal Neoplasms, Hereditary Nonpolyposis Has associated chemicals Has associated genes
3. DiseasesDigestive System Diseases Has associated chemicals Has associated genes Has associated exposure references Digestive System Neoplasms Has associated chemicals Has associated genes Has associated exposure references Gastrointestinal Neoplasms Has associated chemicals Has associated genes Has associated exposure references Intestinal Neoplasms Has associated chemicals Has associated genes Has associated exposure references Colorectal Neoplasms Has associated chemicals Has associated genes Has associated exposure references Colorectal Neoplasms, Hereditary Nonpolyposis Has associated chemicals Has associated genes
4. DiseasesDigestive System Diseases Has associated chemicals Has associated genes Has associated exposure references Gastrointestinal Diseases Has associated chemicals Has associated genes Has associated exposure references Gastrointestinal Neoplasms Has associated chemicals Has associated genes Has associated exposure references Intestinal Neoplasms Has associated chemicals Has associated genes Has associated exposure references Colorectal Neoplasms Has associated chemicals Has associated genes Has associated exposure references Colorectal Neoplasms, Hereditary Nonpolyposis Has associated chemicals Has associated genes
5. DiseasesDigestive System Diseases Has associated chemicals Has associated genes Has associated exposure references Gastrointestinal Diseases Has associated chemicals Has associated genes Has associated exposure references Intestinal Diseases Has associated chemicals Has associated genes Has associated exposure references Colonic Diseases Has associated chemicals Has associated genes Has associated exposure references Colorectal Neoplasms Has associated chemicals Has associated genes Has associated exposure references Colorectal Neoplasms, Hereditary Nonpolyposis Has associated chemicals Has associated genes
6. DiseasesDigestive System Diseases Has associated chemicals Has associated genes Has associated exposure references Gastrointestinal Diseases Has associated chemicals Has associated genes Has associated exposure references Intestinal Diseases Has associated chemicals Has associated genes Has associated exposure references Intestinal Neoplasms Has associated chemicals Has associated genes Has associated exposure references Colorectal Neoplasms Has associated chemicals Has associated genes Has associated exposure references Colorectal Neoplasms, Hereditary Nonpolyposis Has associated chemicals Has associated genes
7. DiseasesCongenital, Hereditary, and Neonatal Diseases and Abnormalities Has associated chemicals Has associated genes Has associated exposure references Genetic Diseases, Inborn Has associated chemicals Has associated genes Has associated exposure references Neoplastic Syndromes, Hereditary Has associated chemicals Has associated genes Has associated exposure references Colorectal Neoplasms, Hereditary Nonpolyposis Has associated chemicals Has associated genes
8. DiseasesNutritional and Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references DNA Repair-Deficiency Disorders Has associated chemicals Has associated genes Colorectal Neoplasms, Hereditary Nonpolyposis Has associated chemicals Has associated genes

Top ↑ Descendants

Colorectal Neoplasms, Hereditary Nonpolyposis Has associated chemicals Has associated genes
  Colorectal cancer, hereditary nonpolyposis, type 1
  Colorectal Cancer, Hereditary Nonpolyposis, Type 3
  Colorectal Cancer, Hereditary Nonpolyposis, Type 4
  Colorectal Cancer, Hereditary Nonpolyposis, Type 5
  Colorectal Cancer, Hereditary Nonpolyposis, Type 6
  Colorectal Cancer, Hereditary Nonpolyposis, Type 7
  Colorectal Cancer, Hereditary Nonpolyposis, Type 8 Has associated chemicals Has associated genes
View node Lynch Syndrome II Has associated chemicals Has associated genes
  Lynch syndrome I (site-specific colonic cancer) Has associated chemicals Has associated genes