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Disease Dermatomyositis

Name Dermatomyositis
Synonyms Adult Type Dermatomyositides | Adult Type Dermatomyositis | Childhood Type Dermatomyositides | Childhood Type Dermatomyositis | Dermatomyositides | Dermatomyositides, Adult Type | Dermatomyositides, Childhood Type | Dermatomyositis, Adult Type | Dermatomyositis, Childhood Type | Dermatopolymyositides | Dermatopolymyositis | Polymyositis-Dermatomyositides | Polymyositis Dermatomyositis | Polymyositis-Dermatomyositis
Definition A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)
Categories Connective tissue disease | Musculoskeletal disease | Nervous system disease | Skin disease
MeSH® ID D003882
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Top ↑ Ancestors

1. DiseasesMusculoskeletal Diseases Has associated chemicals Has associated genes Has associated exposure references Muscular Diseases Has associated chemicals Has associated genes Myositis Has associated chemicals Has associated genes Polymyositis Has associated chemicals Has associated genes Dermatomyositis Has associated chemicals Has associated genes
2. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Neuromuscular Diseases Has associated chemicals Has associated genes Has associated exposure references Muscular Diseases Has associated chemicals Has associated genes Myositis Has associated chemicals Has associated genes Polymyositis Has associated chemicals Has associated genes Dermatomyositis Has associated chemicals Has associated genes
3. DiseasesSkin and Connective Tissue Diseases Has associated chemicals Has associated genes Has associated exposure references Connective Tissue Diseases Has associated chemicals Has associated genes Has associated exposure references Dermatomyositis Has associated chemicals Has associated genes
4. DiseasesSkin and Connective Tissue Diseases Has associated chemicals Has associated genes Has associated exposure references Skin Diseases Has associated chemicals Has associated genes Has associated exposure references Dermatomyositis Has associated chemicals Has associated genes

Top ↑ Descendants

Dermatomyositis Has associated chemicals Has associated genes
  Amyopathic dermatomyositis Has associated chemicals Has associated genes
  C9 Deficiency with Dermatomyositis
  Juvenile dermatomyositis