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Disease Encephalomyelitis, Autoimmune, Experimental

Name Encephalomyelitis, Autoimmune, Experimental
Synonyms Allergic Encephalomyelitis | Allergic Encephalomyelitis, Experimental | Autoimmune Encephalomyelitis, Experimental | Autoimmune Experimental Encephalomyelitis | Encephalomyelitis, Allergic | Encephalomyelitis, Autoimmune Experimental | Encephalomyelitis, Experimental Allergic | Encephalomyelitis, Experimental Autoimmune | Experimental Allergic Encephalomyelitides | Experimental Allergic Encephalomyelitis | Experimental Autoimmune Encephalomyelitis | Experimental Encephalomyelitis, Autoimmune
Definition An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)
Categories Immune system disease | Nervous system disease
MeSH® ID D004681

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1. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Autoimmune Diseases of the Nervous System Has associated chemicals Has associated genes Has associated exposure references Nervous System Autoimmune Disease, Experimental Has associated chemicals Has associated genes Encephalomyelitis, Autoimmune, Experimental Has associated chemicals Has associated genes
2. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Central Nervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Brain Diseases Has associated chemicals Has associated genes Has associated exposure references Leukoencephalopathies Has associated chemicals Has associated genes Has associated exposure references Demyelinating Autoimmune Diseases, CNS Has associated chemicals Has associated genes Has associated exposure references Encephalomyelitis, Autoimmune, Experimental Has associated chemicals Has associated genes
3. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Demyelinating Diseases Has associated chemicals Has associated genes Has associated exposure references Demyelinating Autoimmune Diseases, CNS Has associated chemicals Has associated genes Has associated exposure references Encephalomyelitis, Autoimmune, Experimental Has associated chemicals Has associated genes
4. DiseasesImmune System Diseases Has associated chemicals Has associated genes Has associated exposure references Autoimmune Diseases Has associated chemicals Has associated genes Has associated exposure references Autoimmune Diseases of the Nervous System Has associated chemicals Has associated genes Has associated exposure references Nervous System Autoimmune Disease, Experimental Has associated chemicals Has associated genes Encephalomyelitis, Autoimmune, Experimental Has associated chemicals Has associated genes

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None.