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Disease Heart Diseases

These are exposure studies associated with the disease and all of its children.

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1–50 of 73 results.
  Reference Associated Study Title Author's Summary Study Factors Stressor Receptors Country Medium Exposure Marker Measurements Outcome
1. Schreinemachers DM. (2010). National Health and Nutrition Examination Survey (NHANES) The results indicate that exposure to 2,4-dichlorophenoxyacetic acid was associated with changes in biomarkers that, based on the published literature, have been linked to risk factors for acute myocardial infarction and type 2 diabetes. 2,4-Dichlorophenoxyacetic Acid Study subjects United States urine 2,4-Dichlorophenoxyacetic Acid Details Diabetes Mellitus, Type 2 | Heart Diseases | cellular triglyceride homeostasis | glucose metabolic process | insulin metabolic process | thyroid-stimulating hormone secretion
2. López-Villarrubia E, et al. (2010). Our findings indicate the existence of a short-term association between current exposure levels to air pollutants and total mortality as well as mortality due to heart and respiratory diseases in both Canary cities studied along with evidence that the association on a given day may spread over several successive days. Air Pollutants Spain air Carbon Monoxide | Nitrogen Dioxide | Ozone | Particulate Matter | Sulfur Dioxide Details Death | Heart Diseases | Respiratory Tract Diseases
3. Hansen AB, et al. (2016). Danish Nurse Cohort We examined the association between long-term exposure to particulate matter (PM2.5) and diabetes incidence; non-smokers, obese subjects, and cardiovascular disease patients may be most susceptible to development of diabetes related to air pollution. disease | tobacco Air Pollutants Subjects with disease:Diabetes Mellitus | Subjects with disease:Myocardial Infarction | Subjects with disease:Obesity | Study subjects Denmark air, ambient Nitrogen Dioxide | Nitrogen Oxides | Particulate Matter Details Diabetes Mellitus
4. Symons JM, et al. (2006). The authors evaluated the association between particulate matter PM2.5 exposure and onset of congestive heart failure symptom exacerbation leading to hospital admission; although overall findings were not statistically significant, the identification of case events defined by an 8-hour onset period may be more relevant than either a 24-hour onset period or the admission date for estimating harmful effects. Air Pollutants Subjects with disease:Heart Failure United States air, ambient Carbon Monoxide | Nitrogen Dioxide | Ozone | Particulate Matter Details
5. Medina-Ramón M, et al. (2008). Worcester Heart Attack Study Residential exposure to traffic-related air pollution increases the mortality risk after hospitalization with acute heart failure. Air Pollutants Subjects with disease:Heart Failure United States Details Death
6. Wittkopp S, et al. (2016). Cardiovascular Health and Air Pollution Study We report novel associations of gene expression changes with traffic-related air pollution exposures in a Los Angeles cohort of elderly subjects with coronary artery disease in this exploratory panel study analysis. Air Pollutants | Carbon | Carbon Monoxide | hopane | Nitrogen Dioxide | Nitrogen Oxides | Organic Chemicals | Ozone | Particulate Matter | Polycyclic Aromatic Hydrocarbons | Soot Subjects with disease:Coronary Artery Disease United States air | blood Carbon | Carbon Monoxide | CYP1B1 | HMOX1 | hopane | IL1B | NFE2L2 | Nitrogen Dioxide | Nitrogen Oxides | NQO1 | Organic Chemicals | Ozone | Particulate Matter | Polycyclic Aromatic Hydrocarbons | SELP | SOD2 | Soot Details gene expression
7. Brüske I, et al. (2011). Air Pollution and Inflammatory Response in Myocardial Infarction Survivors: Gene-Environment Interaction in a High Risk Group (AIRGENE) These preliminary findings should be replicated in other study populations because they suggest that the accumulation of acute and subacute effects or the chronic exposure to ambient particulate and gaseous air pollution may result in the promotion of atherosclerosis, mediated, at least in part, by increased levels of lipoprotein-associated phospholipase A2. Air Pollutants | Carbon Monoxide | Nitric Oxide | Nitrogen Dioxide | Ozone | Particulate Matter | Sulfur Dioxide Subjects with disease:Myocardial Infarction Germany air, ambient | plasma Carbon Monoxide | Nitric Oxide | Nitrogen Dioxide | Ozone | Particulate Matter | PLA2G7 | Sulfur Dioxide Details Atherosclerosis
8. Ljungman P, et al. (2009). Air Pollution and Inflammatory Response in Myocardial Infarction Survivors: Gene-Environment Interaction in a High Risk Group (AIRGENE) We found the interleukin-6 response to air pollution is modified by genetic polymorphisms in IL6 and FGB genes, suggesting the effect of gaseous traffic-related air pollution on inflammation may be stronger in genetic subpopulations with ischemic heart disease. disease | genetics Air Pollutants | Carbon Monoxide | Vehicle Emissions Subjects with gene influence:FGB | Subjects with gene influence:IL6 | Subjects with disease:Myocardial Infarction Finland|Germany|
Greece|Italy|
Spain|Sweden
air, ambient | plasma Carbon Monoxide | IL6 | Nitrogen Dioxide | Particulate Matter Details positive regulation of interleukin-6 production
9. Delfino RJ, et al. (2010). Traffic emission sources of organic chemicals represented by polycyclic aromatic hydrocarbons are associated with increased systemic inflammation and explain associations with quasi-ultrafine particle mass. Air Pollutants | hopane | Polycyclic Aromatic Hydrocarbons | Vehicle Emissions Subjects with disease:Coronary Artery Disease United States air, outdoor | plasma Alkanes | Chromium | Copper | hopane | IL6 | Iron | Manganese | Nickel | Particulate Matter | Polycyclic Aromatic Hydrocarbons | TNFRSF1B | Vanadium | Zinc Details
10. Sørensen M, et al. (2017). Danish Diet, Cancer, and Health cohort Study Long-term exposure to Nitrogen Dioxide and road traffic noise was associated with higher risk of heart failure, mainly among men, in both single- and two-pollutant models. genetics Air Pollutants | Nitrogen Dioxide Subjects with disease:Heart Failure | Study subjects Denmark air Nitrogen Dioxide Details Heart Failure
11. Levinsson A, et al. (2014). INTERGENE/ADONIX Air pollution exposure entails an increased risk of acute myocardial infarction, and this risk differed over genotype strata for variants in the GSTP1, GSTT1 and GSTCD genes, albeit not statistically-significantly. genetics Air Pollutants | Nitrogen Dioxide Subjects with gene influence:GSTP1 | Controls for disease:Myocardial Infarction | Subjects with disease:Myocardial Infarction Sweden Nitrogen Dioxide Details Hypertension | Myocardial Infarction
12. Hankey S, et al. (2012). Between-neighborhood differences in estimated ischemic heart disease mortality from air pollution were comparable in magnitude, suggesting that population health benefits from increased physical activity in high-walkability neighborhoods may be offset by adverse effects of air pollution exposure. physical activity Air Pollutants | Nitrogen Oxides | Ozone | Particulate Matter Study subjects United States air Nitrogen Dioxide | Nitrogen Oxides | Ozone | Particulate Matter Details Myocardial Ischemia
13. Liu CB, et al. (2016). Our findings suggest some positive associations between maternal exposure to ambient particulate matter (PM10) during the first two months of pregnancy and fetal cardiovascular malformations. Air Pollutants | Particulate Matter Infants or newborns | Pregnant females China air, ambient Particulate Matter Details Cardiovascular Abnormalities | Ductus Arteriosus, Patent | Heart Septal Defects, Atrial | Heart Septal Defects, Ventricular | Tetralogy of Fallot
14. Monrad M, et al. (2017). Danish Diet, Cancer, and Health cohort Study We found long-term residential traffic-related air pollution to be associated with higher risk of atrial fibrillation. Air Pollutants | Vehicle Emissions Study subjects Denmark air, ambient Nitrogen Dioxide | Nitrogen Oxides Details Atrial Fibrillation
15. Zhang W, et al. (1994). We report early health effects and biological monitoring in persons occupationally exposed to tetraethyl lead in China for the years 1990-1992, including for gasoline depot workers and traffic police officers. Air Pollutants, Occupational | Tetraethyl Lead Workers China air, ambient | urine diethyllead | Lead | triethyllead Details Bradycardia | Tremor
16. Chen CJ, et al. (1996). In this study, we observed a significantly increased ischemic heart disease (ISHD) mortality among residents in the blackfoot disease (BFD)-endemic area, a significantly higher ISHD mortality for BFD patients than for age-, sex-, and residence-matched control subjects, and a dose-response relation between ISHD mortality and long-term exposure to ingested inorganic arsenic. age | disease Arsenic Controls for disease:Peripheral Vascular Diseases | Subjects with disease:Peripheral Vascular Diseases Taiwan, Province of China water, drinking Arsenic Details Death | Myocardial Ischemia
17. Zierold KM, et al. (2004). Respondents with arsenic levels of 2 microg/L or greater were statistically more likely to report a history of depression, high blood pressure, circulatory problems, and bypass surgery than were respondents with arsenic concentrations less than 2 microg/L. Arsenic Study subjects United States water Arsenic Details Depressive Disorder | Heart Diseases | Hypertension
18. Yuan Y, et al. (2007). We conclude that the major impact of arsenic in drinking water on circulatory disease involves acute myocardial infarction and that, in the initial years, it is the main cause of death from arsenic in drinking water, superseded in later years by excess mortality from lung and bladder cancer. Arsenic Study subjects Chile water Arsenic Details Lung Neoplasms | Myocardial Infarction | Urinary Bladder Neoplasms
19. Wade TJ, et al. (2009). This is the first study to document increased arsenic-associated mortality in the Bayingnormen Inner Mongolia region of China. Arsenic Study subjects China water Arsenic Details Coronary Disease | Death | Neoplasms
20. Wang CH, et al. (2010). QT dispersion may be indicated as an early biomarker for atherosclerotic diseases and a significant and strong predictor of cardiovascular mortality in populations with chronic arsenic exposure. Arsenic Study subjects Taiwan, Province of China Details Carotid Artery Diseases | Coronary Artery Disease | regulation of ventricular cardiac muscle cell membrane repolarization
21. Chen Y, et al. (2011). Exposure to arsenic in drinking water is adversely associated with mortality from heart disease, especially among smokers. tobacco Arsenic Study subjects Bangladesh urine | water, drinking Details Cardiovascular Diseases | Death | Myocardial Ischemia
22. Moon KA, et al. (2013). Strong Heart Study (SHS) Low to moderate chronic arsenic exposure, as measured in urine, was prospectively associated with cardiovascular disease incidence and mortality. Arsenic Study subjects United States urine Arsenic Details Cardiovascular Diseases | Coronary Disease | Death | Stroke
23. James KA, et al. (2015). San Luis Valley Diabetes Study (SLVDS) We observed an association between coronary heart disease risk and inorganic arsenic exposure in a chronic low-level arsenic area in the southwestern United States. sex Arsenic Controls for disease:Coronary Disease | Subjects with disease:Coronary Disease | Study subjects United States urine | water, drinking Arsenic Details Coronary Disease
24. D'Ippoliti D, et al. (2015). Results provide new evidence for risk assessment of low-medium concentrations of arsenic and contribute to the ongoing debate about the threshold-dose of effect, suggesting that even concentrations below 10 micrograms per liter carry a mortality risk. sex Arsenic Study subjects Italy Arsenic Details Death | Diabetes Mellitus | Lung Neoplasms | Myocardial Infarction | Peripheral Arterial Disease | Pulmonary Disease, Chronic Obstructive
25. Cui N, et al. (2016). Long-term exposure to arsenic is associated with upregulated mRNA expression for genes AHR and CYP1A1 in the blood, and blood CYP1A1 mRNA (but not AHR mRNA) is associated with prolonged corrected QT interval. diet Arsenic Study subjects China blood | water, drinking AHR | Arsenic | CYP1A1 Details Long QT Syndrome | regulation of heart rate
26. Tseng CH, et al. (2003). It is concluded that ischemic heart disease in the arseniasis-hyperendemic villages in Taiwan was associated with long-term arsenic exposure. Arsenic Study subjects Taiwan, Province of China Arsenic Details Myocardial Ischemia
27. Sanders AP, et al. (2014). In the present study we examined private well water levels of arsenic, cadmium, manganese, and lead across North Carolina, and used a semi-ecologic study design to estimate the association between metal levels and specific birth defect phenotypes. Arsenic | Cadmium | Lead | Manganese Infants or newborns United States Arsenic | Cadmium | Lead | Manganese Details Cleft Lip | Congenital Microtia | Conotruncal cardiac defects | Hypoplastic Left Heart Syndrome | Pyloric Stenosis
28. Thurston GD, et al. (2016). American Cancer Society Cancer Prevention Study II (ACS CPS-II) Long-term fine particulate matter (PM2.5) exposures from fossil fuel combustion, especially coal burning but also from diesel traffic, were associated with increases in ischemic heart disease mortality in this nationwide population. Arsenic | Carbon | Chlorine | Iron | Lead | Manganese | Particulate Matter | Potassium | Selenium | Silicon | Soot | Sulfur Study subjects United States air, ambient | soil Arsenic | Calcium | Carbon | Chlorine | Iron | Lead | Manganese | Nickel | Particulate Matter | Potassium | Selenium | Silicon | Sodium | Soot | Sulfur | Vanadium | Zinc Details Death | Myocardial Ischemia
29. Keil AP, et al. (2017). Lee-Fraumeni Cohort Our analyses suggest that the excess deaths from causes other than respiratory cancers comprise the majority of the excess deaths caused by inhaled arsenic exposure. arsenic trioxide Workers United States air arsenic trioxide Details Death | Heart Diseases | Respiratory Tract Neoplasms
30. LaKind JS, et al. (2012). National Health and Nutrition Examination Survey (NHANES) With scientifically and clinically supportable exclusion criteria and outcome definitions, we consistently found no associations between urinary bisphenol A and heart disease or diabetes across four NHANES datasets. bisphenol A Study subjects United States urine Details Diabetes Mellitus | Heart Diseases
31. Melzer D, et al. (2010). National Health and Nutrition Examination Survey (NHANES) Higher Bisphenol A (BPA) exposure, reflected in higher urinary concentrations of BPA, is consistently associated with reported heart disease in the general adult population of the USA. bisphenol A Study subjects United States urine bisphenol A Details Angina Pectoris | Coronary Disease | Diabetes Mellitus | Myocardial Infarction | alkaline phosphatase activity | lactate dehydrogenase activity
32. Melzer D, et al. (2012). European Prospective Investigation into Cancer and Nutrition (EPIC) Study Associations between higher bisphenol A exposure (reflected in higher urinary concentrations) and incident coronary artery disease during >10 years of follow-up showed trends similar to previously reported cross-sectional findings in the more highly exposed NHANES respondents. bisphenol A Controls for disease:Coronary Artery Disease | Subjects with disease:Coronary Artery Disease United Kingdom urine bisphenol A Details Coronary Artery Disease
33. Wright JM, et al. (2017). This is the first epidemiological study of birth defects and disinfection by-products (DBPs) to examine several individual cardiovascular defects, different exposure surrogate mixtures (sum of chloroform, bromoform, bromodichloromethane, and dibromochloromethane (THM4), brominated trihalomethanes, sum of monochloroacetic acid, dichloroacetic acid, trichloroacetic acid, monobromoacetic acid, and dibromoacetic acid (HAA5), sum of THM4 and HAA5, and various individual DBP species. sex bromoacetate | bromodichloromethane | bromoform | chloroacetic acid | chlorodibromomethane | Chloroform | dibromoacetic acid | Dichloroacetic Acid | Trichloroacetic Acid Fetuses | Pregnant females United States water, drinking Acetates | bromoacetate | bromodichloromethane | bromoform | chloroacetic acid | chlorodibromomethane | Chloroform | dibromoacetic acid | Dichloroacetic Acid | Trichloroacetic Acid | Trihalomethanes Details Cardiovascular Abnormalities | Heart Septal Defects, Atrial | Heart Septal Defects, Ventricular | Pulmonary Valve Stenosis | Tetralogy of Fallot | Transposition of Great Vessels
34. Peters JL, et al. (2010). National Health and Nutrition Examination Survey (NHANES) Environmental exposure to cadmium was associated with significantly increased stroke and heart failure prevalence. sex | tobacco Cadmium Study subjects United States blood | urine Cadmium Details Heart Failure | Stroke
35. Hecht EM, et al. (2016). National Health and Nutrition Examination Survey (NHANES) These descriptive data from a nationally representative sample suggest that cadmium is related to cardiovascular outcomes even after adjustment for smoking status. Cadmium Study subjects United States blood | urine Cadmium Details Myocardial Infarction | Stroke
36. Barregard L, et al. (2016). Malmo Diet and Cancer Study Blood cadmium in the highest quartile was associated with incident cardiovascular disease and mortality in our population-based samples of Swedish adults. tobacco Cadmium Study subjects Sweden blood Cadmium Details Cardiovascular Diseases | Myocardial Ischemia | Stroke
37. Everett CJ, et al. (2008). National Health and Nutrition Examination Survey (NHANES) Our results indicate a possible role for cadmium in coronary heart disease. sex Cadmium Study subjects United States urine Cadmium Details Myocardial Infarction
38. Asgary S, et al. (2017). The present results showed that serum levels of heavy metals are associated with the presence of coronary artery disease. Long-term exposure to trace levels of Lead, Cadmium and Mercury may play a role in the development of coronary atherosclerotic plaques. Cadmium | Lead | Mercury Controls for disease:Coronary Artery Disease | Subjects with disease:Coronary Artery Disease Iran, Islamic Republic of serum Cadmium | Lead | Mercury Details Coronary Artery Disease
39. Dayton SB, et al. (2010). Agricultural Health Study (AHS) We investigated the relationship between agricultural pesticide use and the incidence of myocardial infarction among women in the Agricultural Health Study. Carbofuran | Chlorpyrifos | Coumaphos | metalaxyl | pendimethalin | Trifluralin Study subjects | Workers United States Details Agricultural Workers' Diseases | Myocardial Infarction
40. Wittkopp S, et al. (2013). Our results suggest that, in a small cohort of elderly adults with coronary artery disease, mitochondrial haplogroup U may have lower susceptibility to adverse effects of traffic-related air pollution compared to haplogroup H. genetics Carbon | Carbon Monoxide | hopane | Nitrogen Oxides | Organic Chemicals | Ozone | Particulate Matter | Polycyclic Aromatic Hydrocarbons | Soot Subjects with disease:Coronary Artery Disease United States air Carbon | Carbon Monoxide | hopane | Nitrogen Oxides | Organic Chemicals | Ozone | Particulate Matter | Polycyclic Aromatic Hydrocarbons | Soot Details inflammatory response
41. Kim SY, et al. (2015). Denver Aerosol Sources and Health (DASH) Study Particulate Matter (2.5) components possibly from combustion-related sources are more strongly associated with daily mortality than are secondary inorganic aerosols. Carbon | Carbon Monoxide | Nitrates | Nitrogen Dioxide | Ozone | Particulate Matter | Soot | Sulfates | Sulfur Dioxide Study subjects United States air Carbon | Carbon Monoxide | Nitrates | Nitrogen Dioxide | Ozone | Particulate Matter | Soot | Sulfates | Sulfur Dioxide Details Death | Myocardial Ischemia | Neoplasms
42. Ostro B, et al. (2015). California Teachers Study Our analysis of long-term exposure to the mass and constituents of Particulate Matter (2.5) and ultrafine particles revealed several statistically significant associations with all-cause, cardiovascular, and ischemic heart disease mortality. Carbon | Copper | Iron | Manganese | Nitrates | Organic Chemicals | Particulate Matter Study subjects United States air Carbon | Copper | Iron | Manganese | Nitrates | Organic Chemicals | Particulate Matter Details Cardiovascular Diseases | Death | Myocardial Ischemia
43. Suh HH, et al. (2010). Results indicate decreased vagal tone in response to traffic pollutants, which can best be detected with precise personal exposure measures. Carbon | Nitrogen Dioxide | Ozone | Particulate Matter | Sulfates Subjects with disease:Myocardial Infarction | Subjects with disease:Pulmonary Disease, Chronic Obstructive | Study subjects United States air Carbon | Nitrogen Dioxide | Ozone | Particulate Matter | Sulfates Details heart contraction
44. Ghosh R, et al. (2016). We investigated the coronary heart disease burden from near-roadway air pollution and compared it with the particulate matter <= 2.5 microns burden in the California South Coast Air Basin for 2008 and under a compact urban growth greenhouse gas reduction scenario for 2035. Carbon | Particulate Matter Study subjects United States Carbon | Particulate Matter Details Coronary Disease | Death
45. Berglind N, et al. (2010). Swedish Onset study This study provides no support that moderately elevated air pollution levels trigger first-time myocardial infarction. Carbon Monoxide | Nitrogen Dioxide | Ozone | Particulate Matter Subjects with disease:Myocardial Infarction Sweden air Carbon Monoxide | Nitrogen Dioxide | Ozone | Particulate Matter Details Myocardial Infarction
46. Milojevic A, et al. (2014). This study found no clear evidence for pollution effects on ST-elevation myocardial infarctions and stroke, which ultimately represent thrombogenic processes, though it did for pulmonary embolism. age | sex Carbon Monoxide | Nitrogen Dioxide | Ozone | Particulate Matter | Sulfur Dioxide Study subjects United Kingdom air, ambient Carbon Monoxide | Nitrogen Dioxide | Ozone | Particulate Matter | Sulfur Dioxide Details Arrhythmias, Cardiac | Atrial Fibrillation | Cardiovascular Diseases | Death | Stroke
47. Koken PJ, et al. (2003). In summary, the results of this study in Denver suggest that ozone increases the risk of hospitalization for acute myocardial infarction, coronary atherosclerosis, and pulmonary heart disease. Sulfur dioxide appears to be related to increased hospital stays for cardiac dysrhythmias, and carbon monoxide is significantly associated with congestive heart failure hospitalization. sex Carbon Monoxide | Nitrogen Dioxide | Ozone | Particulate Matter | Sulfur Dioxide Study subjects United States air Carbon Monoxide | Nitrogen Dioxide | Ozone | Sulfur Dioxide Details Arrhythmias, Cardiac | Atherosclerosis | Heart Failure | Myocardial Infarction | Pulmonary Heart Disease
48. Gilboa SM, et al. (2005). A population-based case-control study investigated the association between maternal exposure to air pollutants, carbon monoxide, nitrogen dioxide, ozone, sulfur dioxide, and particulate matter <10 microns in aerodynamic diameter during weeks 3-8 of pregnancy and the risk of selected cardiac birth defects and oral clefts in livebirths and fetal deaths between 1997 and 2000 in seven Texas counties. sex Carbon Monoxide | Nitrogen Dioxide | Ozone | Particulate Matter | Sulfur Dioxide Children United States Details Cleft Lip | Cleft Palate | Conotruncal cardiac defects | Endocardial Cushion Defects | Heart Septal Defects, Atrial | Heart Septal Defects, Ventricular | Tetralogy of Fallot
49. Kim C, et al. (2016). Shanghai Women's Health Study (SWHS) Evidence from this study suggests that past use of coal among women in Shanghai is associated with excess all-cause mortality and from cardiovascular diseases in particular. Coal Study subjects China Details Cardiovascular Diseases | Death | Myocardial Infarction | Neoplasms
50. Lagat DK, et al. (2014). In this pilot study among women of western Kenya, lower kitchen ventilation, airflow limitation, HIV, and occupational dust exposure were associated with isolated right heart failure, overall or in participant subgroups; direct or indirect causality requires further study. Dust Controls for disease:Heart Failure | Subjects with disease:Heart Failure Kenya Details Heart Failure
1–50 of 73 results.