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Disease Heavy Chain Disease

Name Heavy Chain Disease
Synonyms Franklin Disease | Franklin's Disease | Franklins Disease | gamma Chain Disease | gamma-Chain Disease | gamma-Chain Diseases | Heavy Chain Diseases | mu Chain Disease | mu-Chain Disease | mu-Chain Diseases
Definition A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N-(amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes.
Categories Blood disease | Immune system disease | Lymphatic disease
MeSH® ID D006362
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Top ↑ Ancestors

1. DiseasesHemic and Lymphatic Diseases Has associated chemicals Has associated genes Has associated exposure references Hematologic Diseases Has associated chemicals Has associated genes Has associated exposure references Blood Protein Disorders Has associated chemicals Has associated genes Has associated exposure references Paraproteinemias Has associated chemicals Has associated genes Has associated exposure references Heavy Chain Disease
2. DiseasesHemic and Lymphatic Diseases Has associated chemicals Has associated genes Has associated exposure references Lymphatic Diseases Has associated chemicals Has associated genes Has associated exposure references Lymphoproliferative Disorders Has associated chemicals Has associated genes Has associated exposure references Heavy Chain Disease
3. DiseasesImmune System Diseases Has associated chemicals Has associated genes Has associated exposure references Immunoproliferative Disorders Has associated chemicals Has associated genes Has associated exposure references Paraproteinemias Has associated chemicals Has associated genes Has associated exposure references Heavy Chain Disease

Top ↑ Descendants

Heavy Chain Disease
  CHA heavy chain disease protein, human
  FOR heavy chain disease protein, human
  heavy chain disease proteins, human
  IGHM protein, human
  Immunoproliferative Small Intestinal Disease
  RIV immunoglobulin variant protein, human
  Wis heavy-chain disease protein, human