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Disease Hemoglobinuria, Paroxysmal

Name Hemoglobinuria, Paroxysmal
Synonyms Cold Paroxysmal Hemoglobinuria | Hemoglobinuria, Cold Paroxysmal | Hemoglobinuria, Nocturnal Paroxysmal | Hemoglobinuria, Paroxysmal Cold | Hemoglobinuria, Paroxysmal Nocturnal | Marchiafava Micheli Syndrome | Marchiafava-Micheli Syndrome | Nocturnal Paroxysmal Hemoglobinuria | Paroxysmal Cold Hemoglobinuria | Paroxysmal Hemoglobinuria | Paroxysmal Hemoglobinuria, Cold | Paroxysmal Hemoglobinuria, Nocturnal | Paroxysmal Nocturnal Hemoglobinuria | PAROXYSMAL NOCTURNAL HEMOGLOBINURIA 1 | PNH1 | Syndrome, Marchiafava-Micheli
Definition A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.
Categories Blood disease
MeSH® ID D006457
OMIM® ID 300818
External Links

Top ↑ Ancestors

1. DiseasesHemic and Lymphatic Diseases Has associated chemicals Has associated genes Has associated exposure references Hematologic Diseases Has associated chemicals Has associated genes Has associated exposure references Anemia Has associated chemicals Has associated genes Has associated exposure references Anemia, Hemolytic Has associated chemicals Has associated genes Has associated exposure references Hemoglobinuria, Paroxysmal Has associated chemicals Has associated genes
2. DiseasesHemic and Lymphatic Diseases Has associated chemicals Has associated genes Has associated exposure references Hematologic Diseases Has associated chemicals Has associated genes Has associated exposure references Bone Marrow Diseases Has associated chemicals Has associated genes Myelodysplastic Syndromes Has associated chemicals Has associated genes Hemoglobinuria, Paroxysmal Has associated chemicals Has associated genes

Top ↑ Descendants

Hemoglobinuria, Paroxysmal Has associated chemicals Has associated genes
  Bone Marrow failure syndromes Has associated chemicals Has associated genes