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Disease Kernicterus

Name Kernicterus
Synonyms Bilirubin Encephalopathies | Bilirubin Encephalopathy | Encephalopathies, Bilirubin | Encephalopathies, Hyperbilirubinemic | Encephalopathy, Bilirubin | Encephalopathy, Hyperbilirubinemic | Hyperbilirubinemic Encephalopathies | Hyperbilirubinemic Encephalopathy
Definition A term used pathologically to describe BILIRUBIN staining of the BASAL GANGLIA; BRAIN STEM; and CEREBELLUM and clinically to describe a syndrome associated with HYPERBILIRUBINEMIA. Clinical features include athetosis, MUSCLE SPASTICITY or hypotonia, impaired vertical gaze, and DEAFNESS. Nonconjugated bilirubin enters the brain and acts as a neurotoxin, often in association with conditions that impair the BLOOD-BRAIN BARRIER (e.g., SEPSIS). This condition occurs primarily in neonates (INFANT, NEWBORN), but may rarely occur in adults. (Menkes, Textbook of Child Neurology, 5th ed, p613)
Categories Blood disease | Immune system disease | Infant-newborn disease | Metabolic disease | Nervous system disease | Pathology (process)
MeSH® ID D007647
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1. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Central Nervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Brain Diseases Has associated chemicals Has associated genes Has associated exposure references Brain Diseases, Metabolic Has associated chemicals Has associated genes Kernicterus Has associated chemicals Has associated genes
2. DiseasesHemic and Lymphatic Diseases Has associated chemicals Has associated genes Has associated exposure references Hematologic Diseases Has associated chemicals Has associated genes Has associated exposure references Erythroblastosis, Fetal Has associated chemicals Has associated genes Kernicterus Has associated chemicals Has associated genes
3. DiseasesCongenital, Hereditary, and Neonatal Diseases and Abnormalities Has associated chemicals Has associated genes Has associated exposure references Infant, Newborn, Diseases Has associated chemicals Has associated genes Has associated exposure references Erythroblastosis, Fetal Has associated chemicals Has associated genes Kernicterus Has associated chemicals Has associated genes
4. DiseasesNutritional and Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Brain Diseases, Metabolic Has associated chemicals Has associated genes Kernicterus Has associated chemicals Has associated genes
5. DiseasesImmune System Diseases Has associated chemicals Has associated genes Has associated exposure references Erythroblastosis, Fetal Has associated chemicals Has associated genes Kernicterus Has associated chemicals Has associated genes
6. DiseasesPathological Conditions, Signs and Symptoms Has associated chemicals Has associated genes Has associated exposure references Pathologic Processes Has associated chemicals Has associated genes Has associated exposure references Hyperbilirubinemia Has associated chemicals Has associated genes Has associated exposure references Kernicterus Has associated chemicals Has associated genes

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None.