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Disease Leukodystrophy, Globoid Cell

Name Leukodystrophy, Globoid Cell
Synonyms beta-Galactosidase Deficiencies, Galactosylceramide | beta-Galactosidase Deficiency, Galactosylceramide | Cell Leukodystrophies, Globoid | Cell Leukodystrophy, Globoid | Cell Leukoencephalopathies, Globoid | Cell Leukoencephalopathy, Globoid | Classic Globoid Cell Leukodystrophy | Deficiencies, Galactocerebrosidase | Deficiencies, Galactosylceramide beta-Galactosidase | Deficiencies, GALC | Deficiency Disease, Galactosylceramidase | Deficiency Disease, Galactosylceramide-beta-Galactosidase | Deficiency Diseases, Galactosylceramidase | Deficiency Diseases, Galactosylceramide-beta-Galactosidase | Deficiency, Galactocerebrosidase | Deficiency, Galactosylceramide beta-Galactosidase | Deficiency, GALC | Diffuse Globoid Body Sclerosis | Disease, Galactosylceramidase Deficiency | Disease, Galactosylceramide-beta-Galactosidase Deficiency | Diseases, Galactosylceramidase Deficiency | Diseases, Galactosylceramide-beta-Galactosidase Deficiency | Early Onset Globoid Cell Leukodystrophy | Early-Onset Globoid Cell Leukodystrophy | Galactocerebrosidase Deficiencies | Galactocerebrosidase Deficiency | Galactosylceramidase Deficiency Disease | Galactosylceramidase Deficiency Diseases | Galactosylceramide beta-Galactosidase Deficiencies | Galactosylceramide beta Galactosidase Deficiency | Galactosylceramide beta-Galactosidase Deficiency | Galactosylceramide beta Galactosidase Deficiency Disease | Galactosylceramide-beta-Galactosidase Deficiency Disease | Galactosylceramide-beta-Galactosidase Deficiency Diseases | Galactosylceramide Lipidosis | Galactosylcerebrosidase Deficiency | Galactosylsphingosine Lipidosis | GALC Deficiencies | GALC Deficiency | GCL | GLD | Globoid Body Sclerosis, Diffuse | Globoid Cell Leukodystrophies | Globoid Cell Leukodystrophy | Globoid Cell Leukoencephalopathies | Globoid Cell Leukoencephalopathy | Globoid Leukodystrophies | Globoid Leukodystrophy | Infantile Globoid Cell Leukodystrophy | Krabbe Disease | Krabbe Leukodystrophy | Krabbe's Disease | Krabbes Disease | Krabbe's Leukodystrophy | Krabbes Leukodystrophy | Late Onset Globoid Cell Leukodystrophy | Late-Onset Globoid Cell Leukodystrophy | Leukodystrophies, Globoid | Leukodystrophies, Globoid Cell | Leukodystrophy, Globoid | Leukodystrophy, Globoid Cell, Classic | Leukodystrophy, Globoid Cell, Early-Onset | Leukodystrophy, Globoid Cell, Infantile | Leukodystrophy, Globoid Cell, Late-Onset | Leukodystrophy, Krabbe | Leukodystrophy, Krabbe's | Leukoencephalopathies, Globoid Cell | Leukoencephalopathy, Globoid Cell | Psychosine Lipidosis
Definition An autosomal recessive metabolic disorder caused by a deficiency of GALACTOSYLCERAMIDASE leading to intralysosomal accumulation of galactolipids such as GALACTOSYLCERAMIDES and PSYCHOSINE. It is characterized by demyelination associated with large multinucleated globoid cells, predominantly involving the white matter of the central nervous system. The loss of MYELIN disrupts normal conduction of nerve impulses.
Categories Genetic disease (inborn) | Metabolic disease | Nervous system disease
MeSH® ID D007965
OMIM® ID 245200
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1. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Central Nervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Brain Diseases Has associated chemicals Has associated genes Has associated exposure references Brain Diseases, Metabolic Has associated chemicals Has associated genes Brain Diseases, Metabolic, Inborn Has associated chemicals Has associated genes Hereditary Central Nervous System Demyelinating Diseases Has associated chemicals Has associated genes Leukodystrophy, Globoid Cell Has associated chemicals Has associated genes
2. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Central Nervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Brain Diseases Has associated chemicals Has associated genes Has associated exposure references Brain Diseases, Metabolic Has associated chemicals Has associated genes Brain Diseases, Metabolic, Inborn Has associated chemicals Has associated genes Lysosomal Storage Diseases, Nervous System Has associated chemicals Has associated genes Sphingolipidoses Has associated chemicals Has associated genes Leukodystrophy, Globoid Cell Has associated chemicals Has associated genes
3. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Central Nervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Brain Diseases Has associated chemicals Has associated genes Has associated exposure references Leukoencephalopathies Has associated chemicals Has associated genes Has associated exposure references Hereditary Central Nervous System Demyelinating Diseases Has associated chemicals Has associated genes Leukodystrophy, Globoid Cell Has associated chemicals Has associated genes
4. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Demyelinating Diseases Has associated chemicals Has associated genes Has associated exposure references Hereditary Central Nervous System Demyelinating Diseases Has associated chemicals Has associated genes Leukodystrophy, Globoid Cell Has associated chemicals Has associated genes
5. DiseasesCongenital, Hereditary, and Neonatal Diseases and Abnormalities Has associated chemicals Has associated genes Has associated exposure references Genetic Diseases, Inborn Has associated chemicals Has associated genes Has associated exposure references Metabolism, Inborn Errors Has associated chemicals Has associated genes Has associated exposure references Brain Diseases, Metabolic, Inborn Has associated chemicals Has associated genes Hereditary Central Nervous System Demyelinating Diseases Has associated chemicals Has associated genes Leukodystrophy, Globoid Cell Has associated chemicals Has associated genes
6. DiseasesCongenital, Hereditary, and Neonatal Diseases and Abnormalities Has associated chemicals Has associated genes Has associated exposure references Genetic Diseases, Inborn Has associated chemicals Has associated genes Has associated exposure references Metabolism, Inborn Errors Has associated chemicals Has associated genes Has associated exposure references Brain Diseases, Metabolic, Inborn Has associated chemicals Has associated genes Lysosomal Storage Diseases, Nervous System Has associated chemicals Has associated genes Sphingolipidoses Has associated chemicals Has associated genes Leukodystrophy, Globoid Cell Has associated chemicals Has associated genes
7. DiseasesCongenital, Hereditary, and Neonatal Diseases and Abnormalities Has associated chemicals Has associated genes Has associated exposure references Genetic Diseases, Inborn Has associated chemicals Has associated genes Has associated exposure references Metabolism, Inborn Errors Has associated chemicals Has associated genes Has associated exposure references Lipid Metabolism, Inborn Errors Has associated chemicals Has associated genes Lipidoses Has associated chemicals Has associated genes Sphingolipidoses Has associated chemicals Has associated genes Leukodystrophy, Globoid Cell Has associated chemicals Has associated genes
8. DiseasesCongenital, Hereditary, and Neonatal Diseases and Abnormalities Has associated chemicals Has associated genes Has associated exposure references Genetic Diseases, Inborn Has associated chemicals Has associated genes Has associated exposure references Metabolism, Inborn Errors Has associated chemicals Has associated genes Has associated exposure references Lysosomal Storage Diseases Has associated chemicals Has associated genes Lysosomal Storage Diseases, Nervous System Has associated chemicals Has associated genes Sphingolipidoses Has associated chemicals Has associated genes Leukodystrophy, Globoid Cell Has associated chemicals Has associated genes
9. DiseasesNutritional and Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Brain Diseases, Metabolic Has associated chemicals Has associated genes Brain Diseases, Metabolic, Inborn Has associated chemicals Has associated genes Hereditary Central Nervous System Demyelinating Diseases Has associated chemicals Has associated genes Leukodystrophy, Globoid Cell Has associated chemicals Has associated genes
10. DiseasesNutritional and Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Brain Diseases, Metabolic Has associated chemicals Has associated genes Brain Diseases, Metabolic, Inborn Has associated chemicals Has associated genes Lysosomal Storage Diseases, Nervous System Has associated chemicals Has associated genes Sphingolipidoses Has associated chemicals Has associated genes Leukodystrophy, Globoid Cell Has associated chemicals Has associated genes
11. DiseasesNutritional and Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Lipid Metabolism Disorders Has associated chemicals Has associated genes Has associated exposure references Lipidoses Has associated chemicals Has associated genes Sphingolipidoses Has associated chemicals Has associated genes Leukodystrophy, Globoid Cell Has associated chemicals Has associated genes
12. DiseasesNutritional and Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Metabolism, Inborn Errors Has associated chemicals Has associated genes Has associated exposure references Brain Diseases, Metabolic, Inborn Has associated chemicals Has associated genes Hereditary Central Nervous System Demyelinating Diseases Has associated chemicals Has associated genes Leukodystrophy, Globoid Cell Has associated chemicals Has associated genes
13. DiseasesNutritional and Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Metabolism, Inborn Errors Has associated chemicals Has associated genes Has associated exposure references Brain Diseases, Metabolic, Inborn Has associated chemicals Has associated genes Lysosomal Storage Diseases, Nervous System Has associated chemicals Has associated genes Sphingolipidoses Has associated chemicals Has associated genes Leukodystrophy, Globoid Cell Has associated chemicals Has associated genes
14. DiseasesNutritional and Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Metabolism, Inborn Errors Has associated chemicals Has associated genes Has associated exposure references Lipid Metabolism, Inborn Errors Has associated chemicals Has associated genes Lipidoses Has associated chemicals Has associated genes Sphingolipidoses Has associated chemicals Has associated genes Leukodystrophy, Globoid Cell Has associated chemicals Has associated genes
15. DiseasesNutritional and Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Metabolism, Inborn Errors Has associated chemicals Has associated genes Has associated exposure references Lysosomal Storage Diseases Has associated chemicals Has associated genes Lysosomal Storage Diseases, Nervous System Has associated chemicals Has associated genes Sphingolipidoses Has associated chemicals Has associated genes Leukodystrophy, Globoid Cell Has associated chemicals Has associated genes

Top ↑ Descendants

Leukodystrophy, Globoid Cell Has associated chemicals Has associated genes
  Krabbe Disease, Atypical, due to Saposin A Deficiency Has associated chemicals Has associated genes