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Disease Neuritis, Autoimmune, Experimental

Name Neuritis, Autoimmune, Experimental
Synonyms Allergic Neuritis, Experimental | Autoimmune Neuritis, Experimental | Autoimmune Neuropathies, Experimental | Autoimmune Neuropathy, Experimental | EAN (Experimental Allergic Neuritis) | EAN (Experimental Autoimmune Neuritis) | Experimental Allergic Neuritis | Experimental Autoimmune Neuritis | Experimental Autoimmune Neuropathies | Experimental Autoimmune Neuropathy | Neuritis, Experimental Allergic | Neuritis, Experimental Autoimmune | Neuropathies, Experimental Autoimmune | Neuropathy, Experimental Autoimmune
Definition An experimental animal model for the demyelinating disease of GUILLAINE-BARRE SYNDROME. In the most frequently used protocol, animals are injected with a peripheral nerve tissue protein homogenate. After approximately 2 weeks the animals develop a neuropathy secondary to a T cell-mediated autoimmune response directed towards the MYELIN P2 PROTEIN in peripheral nerves. Pathologic findings include a perivascular accumulation of macrophages and T lymphocytes in the peripheral nervous system, similar to that seen in the Guillaine-Barre syndrome. (From Adams et al., Principles of Neurology, 6th ed, p1314; J Neuroimmunol 1998 Apr 1;84(1):40-52)
Categories Immune system disease | Nervous system disease
MeSH® ID D009444

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1. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Autoimmune Diseases of the Nervous System Has associated chemicals Has associated genes Has associated exposure references Nervous System Autoimmune Disease, Experimental Has associated chemicals Has associated genes Neuritis, Autoimmune, Experimental Has associated chemicals Has associated genes
2. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Neuromuscular Diseases Has associated chemicals Has associated genes Has associated exposure references Peripheral Nervous System Diseases Has associated chemicals Has associated genes Neuritis Has associated chemicals Has associated genes Neuritis, Autoimmune, Experimental Has associated chemicals Has associated genes
3. DiseasesImmune System Diseases Has associated chemicals Has associated genes Has associated exposure references Autoimmune Diseases Has associated chemicals Has associated genes Has associated exposure references Autoimmune Diseases of the Nervous System Has associated chemicals Has associated genes Has associated exposure references Nervous System Autoimmune Disease, Experimental Has associated chemicals Has associated genes Neuritis, Autoimmune, Experimental Has associated chemicals Has associated genes

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