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Disease Neuroleptic Malignant Syndrome

Name Neuroleptic Malignant Syndrome
Synonyms Neuroleptic Induced Neuroleptic Malignant Syndrome | Neuroleptic-Induced Neuroleptic Malignant Syndrome | Neuroleptic Malignant Syndrome, Neuroleptic Induced | Neuroleptic-Malignant Syndrome, Neuroleptic Induced | Neuroleptic Malignant Syndromes | NMS (Neuroleptic Malignant Syndrome) | NMSs (Neuroleptic Malignant Syndrome) | Syndrome, Neuroleptic Malignant | Syndromes, Neuroleptic Malignant
Definition A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
Categories Nervous system disease
MeSH® ID D009459
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Top ↑ Ancestors

1. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Central Nervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Brain Diseases Has associated chemicals Has associated genes Has associated exposure references Basal Ganglia Diseases Has associated chemicals Has associated genes Has associated exposure references Neuroleptic Malignant Syndrome Has associated chemicals Has associated genes
2. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Neurotoxicity Syndromes Has associated chemicals Has associated genes Has associated exposure references Neuroleptic Malignant Syndrome Has associated chemicals Has associated genes
3. DiseasesChemically-Induced Disorders Has associated chemicals Has associated genes Has associated exposure references Poisoning Has associated chemicals Has associated genes Has associated exposure references Neurotoxicity Syndromes Has associated chemicals Has associated genes Has associated exposure references Neuroleptic Malignant Syndrome Has associated chemicals Has associated genes

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