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Disease Progeria

Name Progeria
Synonyms HGPS | Hutchinson Gilford Progeria Syndrome | Hutchinson-Gilford Progeria Syndrome | Hutchinson-Gilford Progeria Syndromes | Hutchinson Gilford Syndrome | Hutchinson-Gilford Syndrome | PROGERIA PROGERIA SYNDROME, CHILDHOOD-ONSET, INCLUDED | Progeria Syndrome, Hutchinson-Gilford | Progeria Syndromes, Hutchinson-Gilford
Definition An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature greying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.
Categories Genetic disease (inborn) | Metabolic disease
MeSH® ID D011371
OMIM® ID 176670
External Links

Top ↑ Ancestors

1. DiseasesCongenital, Hereditary, and Neonatal Diseases and Abnormalities Has associated chemicals Has associated genes Has associated exposure references Genetic Diseases, Inborn Has associated chemicals Has associated genes Has associated exposure references Metabolism, Inborn Errors Has associated chemicals Has associated genes Has associated exposure references Progeria Has associated chemicals Has associated genes
2. DiseasesNutritional and Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Metabolism, Inborn Errors Has associated chemicals Has associated genes Has associated exposure references Progeria Has associated chemicals Has associated genes

Top ↑ Descendants

Progeria Has associated chemicals Has associated genes
  Acrogeria, gottron type
  Bird headed dwarfism Montreal type
  Penttinen-Aula syndrome Has associated chemicals Has associated genes
  Petty Laxova Wiedemann syndrome
  Premature Aging Syndrome, Okamoto Type
  Progeria short stature pigmented nevi
View node Progeria Syndrome, Childhood-Onset Has associated chemicals Has associated genes
  Progeroid Facial Appearance with Hand Anomalies
  Progeroid Syndrome, Congenital, Petty Type
  Progeroid syndrome, neonatal
  Ruvalcaba Churesigaew Myhre syndrome