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Disease Retinoblastoma

Name Retinoblastoma
Synonyms Eye Cancer, Retinoblastoma | Familial Retinoblastoma | Familial Retinoblastomas | Glioblastoma, Retinal | Glioblastomas, Retinal | Glioma, Retinal | Gliomas, Retinal | Hereditary Retinoblastoma | Hereditary Retinoblastomas | Neuroblastoma, Retinal | Neuroblastomas, Retinal | RB | RB1 | Retinal Glioblastoma | Retinal Glioblastomas | Retinal Glioma | Retinal Gliomas | Retinal Neuroblastoma | Retinal Neuroblastomas | Retinoblastoma, Familial | Retinoblastoma, Hereditary | Retinoblastomas | Retinoblastomas, Familial | Retinoblastomas, Hereditary | Retinoblastoma, Sporadic | Retinoblastomas, Sporadic | Sporadic Retinoblastoma | Sporadic Retinoblastomas
Definition A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)
Categories Cancer | Eye disease
MeSH® ID D012175
OMIM® ID 180200
External Links

Top ↑ Ancestors

1. DiseasesNeoplasms Has associated chemicals Has associated genes Has associated exposure references Neoplasms by Histologic Type Has associated chemicals Has associated genes Has associated exposure references Neoplasms, Germ Cell and Embryonal Has associated chemicals Has associated genes Has associated exposure references Neuroectodermal Tumors Has associated chemicals Has associated genes Has associated exposure references Neoplasms, Neuroepithelial Has associated chemicals Has associated genes Has associated exposure references Retinoblastoma Has associated chemicals Has associated genes
2. DiseasesNeoplasms Has associated chemicals Has associated genes Has associated exposure references Neoplasms by Histologic Type Has associated chemicals Has associated genes Has associated exposure references Neoplasms, Glandular and Epithelial Has associated chemicals Has associated genes Has associated exposure references Neoplasms, Neuroepithelial Has associated chemicals Has associated genes Has associated exposure references Retinoblastoma Has associated chemicals Has associated genes
3. DiseasesNeoplasms Has associated chemicals Has associated genes Has associated exposure references Neoplasms by Histologic Type Has associated chemicals Has associated genes Has associated exposure references Neoplasms, Nerve Tissue Has associated chemicals Has associated genes Has associated exposure references Neuroectodermal Tumors Has associated chemicals Has associated genes Has associated exposure references Neoplasms, Neuroepithelial Has associated chemicals Has associated genes Has associated exposure references Retinoblastoma Has associated chemicals Has associated genes
4. DiseasesNeoplasms Has associated chemicals Has associated genes Has associated exposure references Neoplasms by Site Has associated chemicals Has associated genes Has associated exposure references Eye Neoplasms Has associated chemicals Has associated genes Retinal Neoplasms Has associated chemicals Has associated genes Retinoblastoma Has associated chemicals Has associated genes
5. DiseasesEye Diseases Has associated chemicals Has associated genes Has associated exposure references Eye Neoplasms Has associated chemicals Has associated genes Retinal Neoplasms Has associated chemicals Has associated genes Retinoblastoma Has associated chemicals Has associated genes
6. DiseasesEye Diseases Has associated chemicals Has associated genes Has associated exposure references Retinal Diseases Has associated chemicals Has associated genes Has associated exposure references Retinal Neoplasms Has associated chemicals Has associated genes Retinoblastoma Has associated chemicals Has associated genes

Top ↑ Descendants

Retinoblastoma Has associated chemicals Has associated genes
  CHROMOSOME 13q14 DELETION SYNDROME
  Osteosarcoma, Retinoblastoma-Related