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Disease Spastic Paraplegia, Hereditary

Name Spastic Paraplegia, Hereditary
Synonyms Autosomal Dominant Hereditary Spastic Paraplegia | Autosomal Dominant Spastic Paraplegia Hereditary | Autosomal Recessive Hereditary Spastic Paraplegia | Autosomal Recessive Spastic Paraplegia, Hereditary | Charcot Marie Tooth Disease with Pyramidal Features, Autosomal Dominant | Charcot-Marie-Tooth Disease with Pyramidal Features, Autosomal Dominant | CMT with Pyramidal Features | Hereditary Autosomal Dominant Spastic Paraplegia | Hereditary Autosomal Recessive Spastic Paraplegia | Hereditary Motor and Sensory Neuropathy 5 | Hereditary Motor And Sensory Neuropathy V | Hereditary Motor Sensory Neuropathy with Pyramidal Signs | Hereditary Motor-Sensory Neuropathy with Pyramidal Signs | Hereditary Spastic Paraplegia | Hereditary, Spastic Paraplegia, Autosomal Dominant | Hereditary Spastic Paraplegia, Autosomal Recessive | Hereditary Spastic Paraplegias | Hereditary, Spastic Paraplegia, X-Linked Recessive | Hereditary X Linked Recessive Spastic Paraplegia | Hereditary X-Linked Recessive Spastic Paraplegia | HMSN 5 | HMSN Type V | HMSN V | HMSN V (Hereditary Motor and Sensory Neuropathy Type V) | Hypertrophic Motor Sensory Neuropathy Spastic Paraplegia | Hypertrophic Motor-Sensory Neuropathy-Spastic Paraplegia | Paraplegia, Hereditary Spastic | Paraplegias, Hereditary Spastic | Paraplegia, Spastic, Hereditary | Peroneal Muscular Atrophy with Pyramidal Features, Autosomal Dominant | Spastic Paraplegia 2 | Spastic Paraplegia, Autosomal Dominant, Hereditary | Spastic Paraplegia, Autosomal Recessive, Hereditary | Spastic Paraplegia, Hereditary, Autosomal Dominant | Spastic Paraplegia, Hereditary, Autosomal Recessive | Spastic Paraplegia, Hereditary, X-Linked Recessive | Spastic Paraplegia Hypertrophic Motor Sensory Neuropathy | Spastic Paraplegia-Hypertrophic Motor-Sensory Neuropathy | Spastic Paraplegias, Hereditary | Spastic Paraplegia Type 2 | Spastic Paraplegia, X-Linked Recessive, Hereditary | Type V Hereditary Motor and Sensory Neuropathy | Type V, HMSN | X-linked Recessive Hereditary Spastic Paraplegia | X Linked Recessive Hereditary Spastic Paraplegia | X-Linked, Spastic Paraplegia, Hereditary
Definition A group of inherited diseases that share similar phenotypes but are genetically diverse. Different genetic loci for autosomal recessive, autosomal dominant, and x-linked forms of hereditary spastic paraplegia have been identified. Clinically, patients present with slowly progressive distal limb weakness and lower extremity spasticity. Peripheral sensory neurons may be affected in the later stages of the disease. (J Neurol Neurosurg Psychiatry 1998 Jan;64(1):61-6; Curr Opin Neurol 1997 Aug;10(4):313-8)
Categories Congenital abnormality | Genetic disease (inborn) | Nervous system disease
MeSH® ID D015419

Top ↑ Ancestors

1. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Nervous System Malformations Has associated chemicals Has associated genes Has associated exposure references Hereditary Sensory and Motor Neuropathy Has associated chemicals Has associated genes Spastic Paraplegia, Hereditary Has associated chemicals Has associated genes
2. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Neurodegenerative Diseases Has associated chemicals Has associated genes Has associated exposure references Heredodegenerative Disorders, Nervous System Has associated chemicals Has associated genes Hereditary Sensory and Motor Neuropathy Has associated chemicals Has associated genes Spastic Paraplegia, Hereditary Has associated chemicals Has associated genes
3. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Neuromuscular Diseases Has associated chemicals Has associated genes Has associated exposure references Peripheral Nervous System Diseases Has associated chemicals Has associated genes Polyneuropathies Has associated chemicals Has associated genes Hereditary Sensory and Motor Neuropathy Has associated chemicals Has associated genes Spastic Paraplegia, Hereditary Has associated chemicals Has associated genes
4. DiseasesCongenital, Hereditary, and Neonatal Diseases and Abnormalities Has associated chemicals Has associated genes Has associated exposure references Congenital Abnormalities Has associated chemicals Has associated genes Has associated exposure references Nervous System Malformations Has associated chemicals Has associated genes Has associated exposure references Hereditary Sensory and Motor Neuropathy Has associated chemicals Has associated genes Spastic Paraplegia, Hereditary Has associated chemicals Has associated genes
5. DiseasesCongenital, Hereditary, and Neonatal Diseases and Abnormalities Has associated chemicals Has associated genes Has associated exposure references Genetic Diseases, Inborn Has associated chemicals Has associated genes Has associated exposure references Heredodegenerative Disorders, Nervous System Has associated chemicals Has associated genes Hereditary Sensory and Motor Neuropathy Has associated chemicals Has associated genes Spastic Paraplegia, Hereditary Has associated chemicals Has associated genes

Top ↑ Descendants

Spastic Paraplegia, Hereditary Has associated chemicals Has associated genes
  Amyotrophic Dystonic Paraplegia
  Arena syndrome
  Ataxia, Spastic, 1, Autosomal Dominant Has associated chemicals Has associated genes
  Ataxia, Spastic, 2, Autosomal Recessive Has associated chemicals Has associated genes
  Ataxia, Spastic, 3, Autosomal Recessive Has associated chemicals Has associated genes
  Bahemuka Brown syndrome
  Costeff optic atrophy syndrome Has associated chemicals Has associated genes
  Fitzsimmons-Guilbert syndrome
  Fitzsimmons-McLachlan-Gilbert syndrome
  Fitzsimmons Walson Mellor syndrome
  Hereditary spastic paralysis, infantile onset ascending Has associated chemicals Has associated genes
  Leukodystrophy, Dysmyelinating, And Spastic Paraparesis With Or Without Dystonia
  Limb Defects, Distal Transverse, with Mental Retardation and Spasticity
  MASA (Mental Retardation, Aphasia, Shuffling Gait, Adducted Thumbs) Syndrome Has associated chemicals Has associated genes
  MAST Syndrome Has associated chemicals Has associated genes
  Mental retardation spasticity ectrodactyly
  Nakamura Osame syndrome
  Roy Maroteaux Kremp syndrome
  Spastic diplegia infantile type
  Spastic paraplegia 10, autosomal dominant Has associated chemicals Has associated genes
  Spastic paraplegia 11, autosomal recessive Has associated chemicals Has associated genes
  Spastic paraplegia 12, autosomal dominant Has associated chemicals Has associated genes
  Spastic paraplegia 13, autosomal dominant Has associated chemicals Has associated genes
  Spastic paraplegia 14, autosomal recessive
  Spastic paraplegia 15, autosomal recessive Has associated chemicals Has associated genes
  Spastic paraplegia 16, X-linked
  Spastic paraplegia 17 Has associated chemicals Has associated genes
  Spastic Paraplegia 18, Autosomal Recessive Has associated chemicals Has associated genes
  Spastic paraplegia 19, autosomal dominant
  Spastic paraplegia 20, autosomal recessive Has associated chemicals Has associated genes
  Spastic paraplegia 23 Has associated chemicals Has associated genes
  Spastic paraplegia 24
  Spastic paraplegia 25, autosomal recessive
  Spastic paraplegia 26, autosomal recessive
  Spastic Paraplegia 27, Autosomal Recessive
  Spastic paraplegia 29, autosomal dominant
  Spastic paraplegia 2, X-linked Has associated chemicals Has associated genes
  Spastic Paraplegia 31, Autosomal Dominant Has associated chemicals Has associated genes
  Spastic Paraplegia 32, Autosomal Recessive
  Spastic Paraplegia 33, Autosomal Dominant Has associated chemicals Has associated genes
  Spastic Paraplegia 34, X-Linked
  SPASTIC PARAPLEGIA 35, AUTOSOMAL RECESSIVE Has associated chemicals Has associated genes
  Spastic Paraplegia 36, Autosomal Dominant
  Spastic Paraplegia 37, Autosomal Dominant
  Spastic Paraplegia 38, Autosomal Dominant
  Spastic Paraplegia 39, Autosomal Recessive Has associated chemicals Has associated genes
  Spastic paraplegia 3, autosomal dominant Has associated chemicals Has associated genes
  SPASTIC PARAPLEGIA 41, AUTOSOMAL DOMINANT
  Spastic Paraplegia 42, Autosomal Dominant Has associated chemicals Has associated genes
  Spastic Paraplegia 44, Autosomal Recessive Has associated chemicals Has associated genes
  SPASTIC PARAPLEGIA 45, AUTOSOMAL RECESSIVE Has associated chemicals Has associated genes
  SPASTIC PARAPLEGIA 48, AUTOSOMAL RECESSIVE Has associated chemicals Has associated genes
  SPASTIC PARAPLEGIA 49, AUTOSOMAL RECESSIVE Has associated chemicals Has associated genes
  Spastic paraplegia 4, autosomal dominant Has associated chemicals Has associated genes
  Spastic Paraplegia-50, Autosomal Recessive Has associated chemicals Has associated genes
  Spastic Paraplegia 5a, Autosomal Recessive
  Spastic paraplegia 6, autosomal dominant Has associated chemicals Has associated genes
  Spastic Paraplegia 7, Autosomal Recessive Has associated chemicals Has associated genes
  Spastic paraplegia 9, autosomal dominant Has associated chemicals Has associated genes
  Spastic Paraplegia And Evans Syndrome
  Spastic paraplegia epilepsy mental retardation
  Spastic paraplegia neuropathy poikiloderma
  Spastic Paraplegia, Optic Atrophy, And Dementia
  Spastic Paraplegia, Optic Atrophy, Microcephaly, And Xy Sex Reversal
  Spastic Paraplegia, Sensorineural Deafness, Mental Retardation, And Progressive Nephropathy
  Spastic Paraplegia Type 4
  Spastic paraplegia type 5A, recessive Has associated chemicals Has associated genes
  Spastic paraplegia type 5B, recessive
  Spastic Paraplegia Type 7
  Spastic Paraplegia Type 8 Has associated chemicals Has associated genes
  Spastic Paraplegia With Associated Extrapyramidal Signs
  Spastic paraplegia with Kallmann syndrome
  Spastic Paraplegia With Myoclonic Epilepsy
  Spastic paraplegia with precocious puberty
  Volcke Soekarman syndrome