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Disease Keratoderma, Palmoplantar, Diffuse

Name Keratoderma, Palmoplantar, Diffuse
Synonyms Keratosis Palmaris et Plantaris Familiaris | Syndrome, Thost-Unna | Syndrome, Unna-Thost | Thost Unna Syndrome | Thost-Unna Syndrome | Tylosis | Unna Thost Syndrome | Unna-Thost Syndrome
Definition An autosomal dominant disorder characterized by a widely distributed, well-demarcated hyperkeratosis of the palms and soles. There is more than one genotypically distinct form, each of which is clinically similar but histologically distinguishable. Diffuse palmoplantar keratoderma is distinct from palmoplantar keratoderma (KERATODERMA, PALMOPLANTAR), as the former exhibits autosomal dominant inheritance and hyperhidrosis is frequently present.
Categories Genetic disease (inborn) | Skin disease
MeSH® ID D015776
External Links

Top ↑ Ancestors

1. DiseasesCongenital, Hereditary, and Neonatal Diseases and Abnormalities Has associated chemicals Has associated genes Has associated exposure references Genetic Diseases, Inborn Has associated chemicals Has associated genes Has associated exposure references Skin Diseases, Genetic Has associated chemicals Has associated genes Has associated exposure references Keratoderma, Palmoplantar Has associated chemicals Has associated genes Keratoderma, Palmoplantar, Diffuse Has associated chemicals Has associated genes
2. DiseasesSkin and Connective Tissue Diseases Has associated chemicals Has associated genes Has associated exposure references Skin Diseases Has associated chemicals Has associated genes Has associated exposure references Keratosis Has associated chemicals Has associated genes Has associated exposure references Keratoderma, Palmoplantar Has associated chemicals Has associated genes Keratoderma, Palmoplantar, Diffuse Has associated chemicals Has associated genes
3. DiseasesSkin and Connective Tissue Diseases Has associated chemicals Has associated genes Has associated exposure references Skin Diseases Has associated chemicals Has associated genes Has associated exposure references Skin Diseases, Genetic Has associated chemicals Has associated genes Has associated exposure references Keratoderma, Palmoplantar Has associated chemicals Has associated genes Keratoderma, Palmoplantar, Diffuse Has associated chemicals Has associated genes

Top ↑ Descendants

Keratoderma, Palmoplantar, Diffuse Has associated chemicals Has associated genes
  Beardwell syndrome
  Diffuse palmoplantar keratoderma, Bothnian type
  Hyperkeratosis of the palms and soles and esophageal papillomas
View node Keratoderma, Palmoplantar, Epidermolytic Has associated chemicals Has associated genes
View node Palmoplantar Keratoderma, Nonepidermolytic Has associated chemicals Has associated genes