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Disease Motor Neuron Disease

Name Motor Neuron Disease
Synonyms Anterior Horn Cell Disease | Familial Motor Neuron Disease | Lateral Scleroses | Lateral Scleroses, Primary | Lateral Sclerosis | Lateral Sclerosis, Primary | Lower Motor Neuron Disease | Motor Neuron Disease, Familial | Motor Neuron Disease, Lower | Motor Neuron Diseases | Motor Neuron Disease, Secondary | Motor Neuron Disease, Upper | Motor System Disease | Motor System Diseases | Neuron Disease, Motor | Neuron Diseases, Motor | Primary Lateral Scleroses | Primary Lateral Sclerosis | Scleroses, Lateral | Scleroses, Primary Lateral | Sclerosis, Lateral | Sclerosis, Primary Lateral | Secondary Motor Neuron Disease | Upper Motor Neuron Disease
Definition Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
Categories Nervous system disease
MeSH® ID D016472
External Links
DO
DOID:230 | DOID:231 | DOID:4873

Top ↑ Ancestors

1. Diseases ← Nervous System Diseases Has associated chemicals Has associated genes Has associated exposure references ← Neurodegenerative Diseases Has associated chemicals Has associated genes Has associated exposure references ← Motor Neuron Disease Has associated chemicals Has associated genes Has associated exposure references
2. Diseases ← Nervous System Diseases Has associated chemicals Has associated genes Has associated exposure references ← Neuromuscular Diseases Has associated chemicals Has associated genes Has associated exposure references ← Motor Neuron Disease Has associated chemicals Has associated genes Has associated exposure references

Top ↑ Descendants

Motor Neuron Disease Has associated chemicals Has associated genes Has associated exposure references
View node Amyotrophic Lateral Sclerosis Has associated chemicals Has associated genes Has associated exposure references
View node Bulbar Palsy, Progressive Has associated chemicals Has associated genes
  Lethal Arthrogryposis With Anterior Horn Cell Disease Has associated chemicals Has associated genes
  Motor Neuron Disease with Dementia and Ophthalmoplegia
View node Muscular Atrophy, Spinal Has associated chemicals Has associated genes Has associated exposure references
  Neuropathy, Hereditary Sensorimotor, with Upper Motor Neuron, Visual Pathway and Autonomic Disturbance
  Primary Lateral Sclerosis, Adult, 1
  Primary lateral sclerosis juvenile Has associated chemicals Has associated genes