Name | Motor Neuron Disease |
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Synonyms | Anterior Horn Cell Disease | Familial Motor Neuron Disease | Lateral Scleroses | Lateral Scleroses, Primary | Lateral Sclerosis | Lateral Sclerosis, Primary | Lower Motor Neuron Disease | Motor Neuron Disease, Familial | Motor Neuron Disease, Lower | Motor Neuron Diseases | Motor Neuron Disease, Secondary | Motor Neuron Disease, Upper | Motor System Disease | Motor System Diseases | Neuron Disease, Motor | Neuron Diseases, Motor | Primary Lateral Scleroses | Primary Lateral Sclerosis | Scleroses, Lateral | Scleroses, Primary Lateral | Sclerosis, Lateral | Sclerosis, Primary Lateral | Secondary Motor Neuron Disease | Upper Motor Neuron Disease |
Definition | Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089) |
Categories | Nervous system disease |
MeSH® ID | D016472 |
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