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Ophthalmoplegia, Chronic Progressive External| Name | Ophthalmoplegia, Chronic Progressive External |
|---|---|
| Synonyms | Chronic Progressive External Ophthalmoplegia | CPEO | Disease, Graefe | Dystrophy, Ocular Muscular | External Ophthalmoplegia, Progressive | Graefe Disease | Graefe's Disease | Mitochondrial Ocular Myopathy | Muscular Dystrophies, Ocular | Muscular Dystrophy, Ocular | Myopathy, Mitochondrial Ocular | Ocular Muscular Dystrophies | Ocular Muscular Dystrophy | Ocular Myopathy, Mitochondrial | Ocular Myopathy of Von Graefe Fuchs | Ocular Myopathy of Von Graefe-Fuchs | Ophthalmoplegia, Progressive External | Progressive External Ophthalmoplegia |
| Definition | A mitochondrial myopathy characterized by slowly progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. Ragged-red fibers and atrophy are found on muscle biopsy. Familial and sporadic forms may occur. Disease onset is usually in the first or second decade of life, and the illness slowly progresses until usually all ocular motility is lost. (From Adams et al., Principles of Neurology, 6th ed, p1422) |
| Categories | Eye disease | Metabolic disease | Musculoskeletal disease | Nervous system disease | Signs and symptoms |
| MeSH® ID | D017246 |
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