Skip navigation

Disease Protein S Deficiency

Name Protein S Deficiency
Synonyms Deficiencies, Protein S | Deficiency, Protein S | Hereditary Thrombophilia Due To Protein S Deficiency | Protein S Deficiencies
Definition An autosomal dominant disorder showing decreased levels of plasma protein S antigen or activity, associated with venous thrombosis and pulmonary embolism. PROTEIN S is a vitamin K-dependent plasma protein that inhibits blood clotting by serving as a cofactor for activated PROTEIN C (also a vitamin K-dependent protein), and the clinical manifestations of its deficiency are virtually identical to those of protein C deficiency. Treatment with heparin for acute thrombotic processes is usually followed by maintenance administration of coumarin drugs for the prevention of recurrent thrombosis. (From Harrison's Principles of Internal Medicine, 12th ed, p1511; Wintrobe's Clinical Hematology, 9th ed, p1523)
Categories Blood disease
MeSH® ID D018455
External Links

Top ↑ Ancestors

1. DiseasesHemic and Lymphatic Diseases Has associated chemicals Has associated genes Has associated exposure references Hematologic Diseases Has associated chemicals Has associated genes Has associated exposure references Blood Coagulation Disorders Has associated chemicals Has associated genes Protein S Deficiency Has associated chemicals Has associated genes
2. DiseasesHemic and Lymphatic Diseases Has associated chemicals Has associated genes Has associated exposure references Hematologic Diseases Has associated chemicals Has associated genes Has associated exposure references Blood Protein Disorders Has associated chemicals Has associated genes Has associated exposure references Protein S Deficiency Has associated chemicals Has associated genes
3. DiseasesHemic and Lymphatic Diseases Has associated chemicals Has associated genes Has associated exposure references Hematologic Diseases Has associated chemicals Has associated genes Has associated exposure references Thrombophilia Has associated chemicals Has associated genes Protein S Deficiency Has associated chemicals Has associated genes

Top ↑ Descendants

Protein S Deficiency Has associated chemicals Has associated genes
  Acquired Protein S Deficiency
  Thrombophilia, Hereditary, Due To Protein S Deficiency, Autosomal Dominant Has associated chemicals Has associated genes
  Thrombophilia, Hereditary, Due To Protein S Deficiency, Autosomal Recessive