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Disease Multiple Endocrine Neoplasia Type 2a

Name Multiple Endocrine Neoplasia Type 2a
Synonyms MEA 2a | MEA II | MEA IIa | MEN 2 | MEN2a | MEN 2a | MEN 2A Syndrome | MEN-2A Syndrome | MEN-2A Syndromes | MEN II | MEN IIa | Multiple Endocrine Neoplasia Type 2 | Multiple Endocrine Neoplasia, Type IIa | Multiple Endocrine Neoplasms Type 2a | Neoplasia, Multiple Endocrine Type 2a | Neoplasms, Multiple Endocrine Type 2a | Pheochromocytoma And Amyloid Producing Medullary Thyroid Carcinoma | Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma | PTC SYNDROME | Sipple Syndrome | SIPPLE SYNDROME THYROID CARCINOMA, FAMILIAL MEDULLARY, INCLUDED
Definition A form of multiple endocrine neoplasia characterized by the presence of medullary carcinoma (CARCINOMA, MEDULLARY) of the THYROID GLAND, and usually with the co-occurrence of PHEOCHROMOCYTOMA, producing CALCITONIN and ADRENALINE, respectively. Less frequently, it can occur with hyperplasia or adenoma of the PARATHYROID GLANDS. This disease is due to gain-of-function mutations of the MEN2 gene on CHROMOSOME 10 (Locus: 10q11.2), also known as the RET proto-oncogene that encodes a RECEPTOR PROTEIN-TYROSINE KINASE. It is an autosomal dominant inherited disease.
Categories Cancer | Endocrine system disease | Genetic disease (inborn)
MeSH® ID D018813
OMIM® ID 171400
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Top ↑ Ancestors

1. DiseasesNeoplasms Has associated chemicals Has associated genes Has associated exposure references Neoplasms by Site Has associated chemicals Has associated genes Has associated exposure references Endocrine Gland Neoplasms Has associated chemicals Has associated genes Has associated exposure references Multiple Endocrine Neoplasia Has associated chemicals Has associated genes Multiple Endocrine Neoplasia Type 2a Has associated chemicals Has associated genes
2. DiseasesNeoplasms Has associated chemicals Has associated genes Has associated exposure references Neoplasms, Multiple Primary Has associated chemicals Has associated genes Multiple Endocrine Neoplasia Has associated chemicals Has associated genes Multiple Endocrine Neoplasia Type 2a Has associated chemicals Has associated genes
3. DiseasesNeoplasms Has associated chemicals Has associated genes Has associated exposure references Neoplastic Syndromes, Hereditary Has associated chemicals Has associated genes Has associated exposure references Multiple Endocrine Neoplasia Has associated chemicals Has associated genes Multiple Endocrine Neoplasia Type 2a Has associated chemicals Has associated genes
4. DiseasesCongenital, Hereditary, and Neonatal Diseases and Abnormalities Has associated chemicals Has associated genes Has associated exposure references Genetic Diseases, Inborn Has associated chemicals Has associated genes Has associated exposure references Neoplastic Syndromes, Hereditary Has associated chemicals Has associated genes Has associated exposure references Multiple Endocrine Neoplasia Has associated chemicals Has associated genes Multiple Endocrine Neoplasia Type 2a Has associated chemicals Has associated genes
5. DiseasesEndocrine System Diseases Has associated chemicals Has associated genes Has associated exposure references Endocrine Gland Neoplasms Has associated chemicals Has associated genes Has associated exposure references Multiple Endocrine Neoplasia Has associated chemicals Has associated genes Multiple Endocrine Neoplasia Type 2a Has associated chemicals Has associated genes

Top ↑ Descendants

Multiple Endocrine Neoplasia Type 2a Has associated chemicals Has associated genes
  Familial medullary thyroid carcinoma Has associated chemicals Has associated genes