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Disease Multiple Endocrine Neoplasia Type 2b

Name Multiple Endocrine Neoplasia Type 2b
Synonyms MEA 2b | MEA IIb | MEN2b | MEN 2b | MEN 3 | MEN IIb | MEN III | Mucosal Neuroma Syndrome | Mucosal Neuroma Syndromes | Multiple Endocrine Neoplasia, Type 2b | Multiple Endocrine Neoplasia, Type IIb | MULTIPLE ENDOCRINE NEOPLASIA, TYPE III, FORMERLY;MEN3, FORMERLY MUCOSAL NEUROMA SYNDROME, INCLUDED | Multiple Endocrine Neoplasms Type 2b | Neoplasia, Multiple Endocrine Type 2b | Neoplasms, Multiple Endocrine Type 2b | Neuroma Syndrome, Mucosal | Neuromata, Mucosal, With Endocrine Tumors | Syndrome, Wagenmann-Froboese | Wagenmann Froboese Syndrome | Wagenmann-Froboese Syndrome
Definition Similar to MEN2A, it is also caused by mutations of the MEN2 gene, also known as the RET proto-oncogene. Its clinical symptoms include medullary carcinoma (CARCINOMA, MEDULLARY) of THYROID GLAND and PHEOCHROMOCYTOMA of ADRENAL MEDULLA (50%). Unlike MEN2a, MEN2b does not involve PARATHYROID NEOPLASMS. It can be distinguished from MEN2A by its neural abnormalities such as mucosal NEUROMAS on EYELIDS; LIP; and TONGUE, and ganglioneuromatosis of GASTROINTESTINAL TRACT leading to MEGACOLON. It is an autosomal dominant inherited disease.
Categories Cancer | Endocrine system disease | Genetic disease (inborn)
MeSH® ID D018814
OMIM® ID 162300
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1. DiseasesNeoplasms Has associated chemicals Has associated genes Has associated exposure references Neoplasms by Site Has associated chemicals Has associated genes Has associated exposure references Endocrine Gland Neoplasms Has associated chemicals Has associated genes Has associated exposure references Multiple Endocrine Neoplasia Has associated chemicals Has associated genes Multiple Endocrine Neoplasia Type 2b Has associated chemicals Has associated genes
2. DiseasesNeoplasms Has associated chemicals Has associated genes Has associated exposure references Neoplasms, Multiple Primary Has associated chemicals Has associated genes Multiple Endocrine Neoplasia Has associated chemicals Has associated genes Multiple Endocrine Neoplasia Type 2b Has associated chemicals Has associated genes
3. DiseasesNeoplasms Has associated chemicals Has associated genes Has associated exposure references Neoplastic Syndromes, Hereditary Has associated chemicals Has associated genes Has associated exposure references Multiple Endocrine Neoplasia Has associated chemicals Has associated genes Multiple Endocrine Neoplasia Type 2b Has associated chemicals Has associated genes
4. DiseasesCongenital, Hereditary, and Neonatal Diseases and Abnormalities Has associated chemicals Has associated genes Has associated exposure references Genetic Diseases, Inborn Has associated chemicals Has associated genes Has associated exposure references Neoplastic Syndromes, Hereditary Has associated chemicals Has associated genes Has associated exposure references Multiple Endocrine Neoplasia Has associated chemicals Has associated genes Multiple Endocrine Neoplasia Type 2b Has associated chemicals Has associated genes
5. DiseasesEndocrine System Diseases Has associated chemicals Has associated genes Has associated exposure references Endocrine Gland Neoplasms Has associated chemicals Has associated genes Has associated exposure references Multiple Endocrine Neoplasia Has associated chemicals Has associated genes Multiple Endocrine Neoplasia Type 2b Has associated chemicals Has associated genes

Top ↑ Descendants

Multiple Endocrine Neoplasia Type 2b Has associated chemicals Has associated genes
  Ganglioneuromatosis of the Alimentary Tract