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Disease Neurodegenerative Diseases

These are exposure studies associated with the disease and all of its children.

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1–29 of 29 results.
  Reference Associated Study Title Author's Summary Study Factors Stressor Receptors Country Medium Exposure Marker Measurements Outcome
1. Malek AM, et al. (2015). A potential association was found for exposure to ambient air concentrations of suspected neurotoxicant hazardous air pollutants, specifically aromatic solvents, among place of residence in 2002 and 1999 and risk of Amyotrophic Lateral Sclerosis. 1,1,1-trichloroethane | 1,1,2,2-tetrachloroethane | 2,4-dinitrotoluene | Acrylamide | allyl chloride | Arsenicals | Benzene | Cadmium Compounds | Carbon Disulfide | Carbon Tetrachloride | Chloroform | Cresols | Cyanides | ethylbenzene | Ethylene Dibromide | ethylene dichloride | Ethylene Oxide | Hexachlorobenzene | hexachloroethane | Hexanes | hydrazine | Lead | Manganese Compounds | Mercury Compounds | Methyl Chloride | Methylene Chloride | Nickel | Polychlorinated Biphenyls | Selenium Compounds | Styrene | Tetrachloroethylene | Toluene | Trichloroethylene | Vinyl Chloride | Xylenes Controls for disease:Amyotrophic Lateral Sclerosis | Subjects with disease:Amyotrophic Lateral Sclerosis United States 1,1,1-trichloroethane | 1,1,2,2-tetrachloroethane | 2,4-dinitrotoluene | Acrylamide | allyl chloride | Arsenicals | Benzene | Cadmium Compounds | Carbon Disulfide | Carbon Tetrachloride | Chloroform | Cresols | Cyanides | ethylbenzene | Ethylene Dibromide | ethylene dichloride | Ethylene Oxide | Hexachlorobenzene | hexachloroethane | Hexanes | hydrazine | Lead | Manganese Compounds | Mercury Compounds | Methyl Chloride | Methylene Chloride | Nickel | Polychlorinated Biphenyls | Selenium Compounds | Styrene | Tetrachloroethylene | Toluene | Trichloroethylene | Vinyl Chloride | Xylenes Details Amyotrophic Lateral Sclerosis
2. Kamel F, et al. (2007). Agricultural Health Study (AHS) This study suggests that exposure to certain pesticides may increase Parkinson's disease risk. 2,4,5-Trichlorophenoxyacetic Acid | Benomyl | butylate | Carbon Disulfide | Carbon Tetrachloride | cyanazine | Dicamba | Ethylene Dibromide | Lindane | mancozeb | Maneb | methyl bromide | Paraquat | pendimethalin | Pesticides | Phorate | tetrachloroisophthalonitrile Study subjects | Workers United States Details Agricultural Workers' Diseases | Parkinson Disease
3. Beard JD, et al. (2016). Genes and Environmental Exposures in Veterans with Amyotrophic Lateral Sclerosis (GENEVA) We evaluated associations between military-related factors and amyotrophic lateral sclerosis using data from a case-control study of US military veterans; among some of the positive associations (needing confirmation) were exposure to military herbicides, military nasopharyngeal radium, and Agent Orange. Agent Orange | Defoliants, Chemical | Radium Subjects with disease:Amyotrophic Lateral Sclerosis | Veterans United States Details Amyotrophic Lateral Sclerosis
4. Liu R, et al. (2016). Parkinson's Genes and Environment Study (PAGE) Overall, we found limited evidence for an association between exposures to ambient particulate matter PM10, PM2.5, or nitrogen dioxide and Parkinson disease risk; however, the suggestive evidence that exposures to PM2.5 and PM10 may increase disease risk among female never-smokers warrants further investigation. sex | tobacco Air Pollutants Controls for disease:Parkinson Disease | Subjects with disease:Parkinson Disease United States air, ambient Nitrogen Dioxide | Particulate Matter Details Parkinson Disease
5. Kamel F, et al. (2012). Agricultural Health Study (AHS) The meta-analysis suggests that amyotrophic lateral sclerosis risk is associated with use of pesticides as a group, and our analysis of Agricultural Health Study data points to organochlorine insecticide use in particular. Aldrin | DDT | Dieldrin | Herbicides | Hydrocarbons, Chlorinated | Pesticides | Pyrethrins | Toxaphene Study subjects | Workers United States Details Agricultural Workers' Diseases | Amyotrophic Lateral Sclerosis
6. Kamel F, et al. (2014). Agricultural Health Study (AHS) | Farming and Movement Evaluation Study (FAME) Polyunsaturated fatty acid intake was consistently associated with lower Parkinson's disease (PD) risk, and dietary fats modified the association of PD risk with pesticide exposure. alpha-Linolenic Acid | Fatty Acids | Fatty Acids, Unsaturated | Paraquat | Rotenone Controls for disease:Parkinson Disease | Subjects with disease:Parkinson Disease | Workers United States Details Agricultural Workers' Diseases | Parkinson Disease
7. Vinceti M, et al. (2010). Based on these results, coupled with other epidemiologic data and with findings from animal studies that show specific toxicity of the trace element on motor neurons, we hypothesize that dietary intake of inorganic selenium through drinking water increases the risk for amyotrophic lateral sclerosis. diet Aluminum | Arsenic | Cadmium | Chromium | Copper | Iron | Lead | Lithium | Manganese | Selenic Acid | Zinc Study subjects Italy water, well Aluminum | Arsenic | Cadmium | Chromium | Copper | Iron | Lead | Lithium | Manganese | Selenic Acid | Zinc Details Amyotrophic Lateral Sclerosis
8. Rondeau V, et al. (2009). Aluminum Maladie d'Alzheimer (ALMA+) | Personnes Agees Quid Study (PAQUID) We found that the cognitive decline and the risk of dementia were higher for high consumption of Aluminum from drinking water. age Aluminum | Silicon Dioxide Study subjects France water, drinking, bottled | water, tap Aluminum | Silicon Dioxide Details Alzheimer Disease | cognition
9. Min JY, et al. (2016). National Health and Nutrition Examination Survey (NHANES) We observed a significant association between blood cadmium levels and Alzheimer disease mortality among older adults in the US. age Cadmium Controls for disease:Diabetes Mellitus | Subjects with disease:Diabetes Mellitus | Controls for disease:Hypertension | Subjects with disease:Hypertension | Study subjects United States blood Cadmium Details Alzheimer Disease
10. Ritz B, et al. (2016). We found ambient air pollution from traffic sources to be associated with risk of Parkinson's Disease, with a 9% higher risk (95% CI: 3, 16.0%) per interquartile range increase (2.97 micrograms per cubic meter) in modeled nitrogen dioxide. Carbon Monoxide | Nitric Oxide | Nitrogen Dioxide Controls for disease:Parkinson Disease | Subjects with disease:Parkinson Disease Denmark Carbon Monoxide | Nitric Oxide | Nitrogen Dioxide Details Parkinson Disease
11. Manthripragada AD, et al. (2010). Parkinson's Environment and Genes Study (PEG) The increase in risk we observed among PON1-55 variant carriers for specific organophosphates metabolized by PON1 underscores the importance of considering susceptibility factors when studying environmental exposures in Parkinson disease. genetics Chlorpyrifos | Diazinon | Pesticides Subjects with gene influence:PON1 United States Chlorpyrifos | Diazinon | Pesticides Details Parkinson Disease
12. Yu Y, et al. (2014). Commercial pesticide (occupational exposure) and fertilizer (residential exposure) were both significantly associated with amyotrophic lateral sclerosis in a randomly selected set of patients; these results need to be interpreted cautiously given the small sample size and the lack of direct exposure measures, but they suggest that environmental, occupational, and residential factors warrant close attention in studies examining risk factors for this disease. Fertilizers | Pesticides Controls for disease:Amyotrophic Lateral Sclerosis | Subjects with disease:Amyotrophic Lateral Sclerosis United States Details Amyotrophic Lateral Sclerosis
13. Laidlaw MA, et al. (2015). Legacy petrol lead emissions are associated with increased motor neuron disease death trends in Australia; further examination of the 20 year lag between exposure to petrol lead and onset is warranted. Gasoline Australia air, ambient Lead Details Death | Motor Neuron Disease
14. Narayan S, et al. (2015). This study lends support to a previous report that commonly used pesticides, specifically organochlorines and organophosphorous compounds, and variant ABCB1 genotypes at two polymorphic sites jointly increase risk of Parkinson's Disease. genetics Hydrocarbons, Chlorinated | Organophosphorus Compounds | Pesticides Subjects with gene influence:ABCB1 | Workers United States Details Parkinson Disease
15. Weisskopf MG, et al. (2010). Normative Aging Study (NAS) These findings, using an objective biological marker of cumulative lead exposure among typical Parkinson Disease (PD) patients seen in our movement disorders clinics, strengthen the evidence that cumulative exposure to lead increases the risk of PD. Lead Study subjects United States patella | tibia Lead Details Parkinson Disease
16. Fang F, et al. (2010). Genes and Environmental Exposures in Veterans with Amyotrophic Lateral Sclerosis (GENEVA) | Veterans with ALS and Lead Exposure (VALE) In summary, we found that elevated blood lead level was associated with higher odds of Amyotrophic Lateral Sclerosis among US veterans, regardless of bone turnover or ALAD genotype. Lead Subjects with disease:Amyotrophic Lateral Sclerosis | Subjects with disease:Motor Neuron Disease | Subjects with disease:Muscular Atrophy, Spinal | Veterans United States blood Lead Details Amyotrophic Lateral Sclerosis
17. Costello S, et al. (2009). This study provides evidence that exposure to a combination of maneb and paraquat increases Parkinson's Disease risk, particularly in younger subjects and/or when exposure occurs at younger ages. age Maneb | Paraquat Study subjects United States Details Parkinson Disease
18. Ritz BR, et al. (2009). Our population-based case-control study of Parkinson's Disease (PD) conducted in a California population heavily exposed to pesticides replicates and extends evidence for an association between dopamine transporter (DAT) variants and PD and highlights possible interactions of disease-associated DAT susceptibility alleles and pesticide exposure. genetics Maneb | Paraquat Subjects with gene influence:SLC6A3 | Workers United States Details Parkinson Disease
19. Szabo ST, et al. (2016). We examined the relationship between metal levels in brain tissue and ventricular fluid from postmortem samples of Alzheimer disease cases and controls; we confirmed previous work suggesting an increase in iron in Alzheimer brain tissue and identified arsenic as a metal of interest for further evaluation. Metals Controls for disease:Alzheimer Disease | Subjects with disease:Alzheimer Disease United States frontal lobe | ventricular fluid Arsenic | Cadmium | Chromium | Copper | Iron | Lead | Manganese | Mercury | Nickel | Tin | Vanadium | Zinc Details Alzheimer Disease
20. Oudin A, et al. (2016). Betula Study We observed associations between dementia incidence and local traffic pollution that remained after adjusting for known risk factors. Nitrogen Oxides Study subjects Sweden Nitrogen Oxides Details Alzheimer Disease | Dementia, Vascular
21. Kirrane EF, et al. (2015). Agricultural Health Study (AHS) We observed positive associations of Parkinson disease with ozone and fine particulate matter in North Carolina but not in Iowa. Ozone | Particulate Matter Workers United States Details Parkinson Disease
22. Goldman SM, et al. (2012). Agricultural Health Study (AHS) | Farming and Movement Evaluation Study (FAME) The present study tested the hypothesis that the association between paraquat and Parkinson Disease risk is enhanced in those with homozygous deletions of GSTT1 or GSTM1. genetics Paraquat Subjects with gene influence:GSTM1 | Subjects with gene influence:GSTT1 | Workers United States Details Agricultural Workers' Diseases | Parkinson Disease
23. Furlong M, et al. (2015). Farming and Movement Evaluation Study (FAME) Although sample size was limited, protective glove use and hygiene practices appeared to be important modifiers of the association between pesticides and Parkinson disease and may reduce risk of Parkinson disease associated with certain pesticides. Paraquat | Permethrin | Rotenone | Trifluralin Workers United States Details Parkinson Disease
24. Tanner CM, et al. (2011). Agricultural Health Study (AHS) | Farming and Movement Evaluation Study (FAME) Parkinson's Disease (PD) was positively associated with two groups of pesticides defined by mechanisms implicated experimentally-those that impair mitochondrial function and those that increase oxidative stress-supporting a role for these mechanisms in PD pathophysiology. Paraquat | Rotenone Workers United States Details Agricultural Workers' Diseases | Parkinson Disease
25. Kioumourtzoglou MA, et al. (2016). We conducted a large-scale, multi-city study to estimate the impact of long-term particulate matter <=2.5 microns city-wide exposure on city-wide hospital admissions for neurological outcomes, using data from Medicare enrollees in the northeastern United States. Particulate Matter Study subjects United States air Particulate Matter Details Alzheimer Disease | Dementia | Parkinson Disease
26. Palacios N, et al. (2014). Nurses' Health Study (NHS) In summary, overall the results of this large cohort study of female nurses do not support an effect of air pollution on Parkinson Disease risk. Particulate Matter Workers United States air Particulate Matter Details Parkinson Disease
27. Paul KC, et al. (2015). We found that organophosphate pesticides were more strongly associated with Parkinson disease among participants with variant genotypes in NOS1, consistent with the importance of oxidative stress-inducing mechanisms. genetics Pesticides Subjects with gene influence:NOS1 | Controls for disease:Parkinson Disease | Subjects with disease:Parkinson Disease United States Details Parkinson Disease
28. Dick FD, et al. (2007). The association of pesticide exposure with Parkinson's disease suggests a causative role; repeated traumatic loss of consciousness is also associated with increased risk. Pesticides Controls for disease:Parkinson Disease | Subjects with disease:Parkinson Disease Italy|Malta|
Romania|Sweden|
United Kingdom
Details
29. Dick FD, et al. (2007). Geoparkinson Study GSTM1 null subjects heavily exposed to solvents appear to be at increased risk of Parkinson's disease. genetics Solvents Subjects with gene influence:GSTM1 United Kingdom Details Parkinson Disease
1–29 of 29 results.