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Disease MPTP Poisoning

Name MPTP Poisoning
Synonyms MPTP Induced Degeneration of the Striatum | MPTP-Induced Degeneration of the Striatum | MPTP Induced Parkinsonism | MPTP-Induced Parkinsonism | MPTP Neurotoxicity Syndrome | MPTP Neurotoxicity Syndromes | Neurotoxicity Syndrome, MPTP | Neurotoxicity Syndromes, MPTP | Parkinsonism, MPTP-Induced | Poisoning, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine | Poisoning, MPTP
Definition A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)
Categories Nervous system disease
MeSH® ID D020267

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1. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Central Nervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Brain Diseases Has associated chemicals Has associated genes Has associated exposure references Basal Ganglia Diseases Has associated chemicals Has associated genes Has associated exposure references Parkinsonian Disorders Has associated chemicals Has associated genes Has associated exposure references Parkinson Disease, Secondary Has associated chemicals Has associated genes Has associated exposure references MPTP Poisoning Has associated chemicals Has associated genes
2. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Central Nervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Movement Disorders Has associated chemicals Has associated genes Has associated exposure references Parkinsonian Disorders Has associated chemicals Has associated genes Has associated exposure references Parkinson Disease, Secondary Has associated chemicals Has associated genes Has associated exposure references MPTP Poisoning Has associated chemicals Has associated genes
3. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Neurotoxicity Syndromes Has associated chemicals Has associated genes Has associated exposure references MPTP Poisoning Has associated chemicals Has associated genes
4. DiseasesChemically-Induced Disorders Has associated chemicals Has associated genes Has associated exposure references Poisoning Has associated chemicals Has associated genes Has associated exposure references Neurotoxicity Syndromes Has associated chemicals Has associated genes Has associated exposure references MPTP Poisoning Has associated chemicals Has associated genes

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