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Disease Paralysis, Hyperkalemic Periodic

Name Paralysis, Hyperkalemic Periodic
Synonyms Adynamia Episodica Hereditaria | Adynamia Episodica Hereditaria with or without Myotonia | Disease, Gamstorp | Familial Hyperkalemic Periodic Paralysis | Gamstorp Disease | GAMSTORP DISEASE NORMOKALEMIC PERIODIC PARALYSIS, POTASSIUM-SENSITIVE, INCLUDED | Gamstorp Episodic Adynamy | Hyperkalemic Periodic Paralysis | Hyperkalemic Periodic Paralysis, Familial | Hyperkalemic Periodic Paralysis Type 2 | Hyperkaliemic Periodic Paralysis Type 2 | HyperKPP | HyperPP | HYPP | Myotonic Periodic Paralysis | Paralysis, Periodic, Hyperkalemic, Familial | Primary Hyperkalemic Periodic Paralysis | Sodium Channel Muscle Disease
Definition An autosomal dominant familial disorder which presents in infancy or childhood and is characterized by episodes of weakness associated with hyperkalemia. During attacks, muscles of the lower extremities are initially affected, followed by the lower trunk and arms. Episodes last from 15-60 minutes and typically occur after a period of rest following exercise. A defect in skeletal muscle sodium channels has been identified as the cause of this condition. Normokalemic periodic paralysis is a closely related disorder marked by a lack of alterations in potassium levels during attacks of weakness. (Adams et al., Principles of Neurology, 6th ed, p1481)
Categories Genetic disease (inborn) | Metabolic disease | Musculoskeletal disease | Nervous system disease
MeSH® ID D020513
OMIM® ID 170500
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1. DiseasesMusculoskeletal Diseases Has associated chemicals Has associated genes Has associated exposure references Muscular Diseases Has associated chemicals Has associated genes Paralyses, Familial Periodic Has associated chemicals Has associated genes Paralysis, Hyperkalemic Periodic Has associated chemicals Has associated genes
2. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Neuromuscular Diseases Has associated chemicals Has associated genes Has associated exposure references Muscular Diseases Has associated chemicals Has associated genes Paralyses, Familial Periodic Has associated chemicals Has associated genes Paralysis, Hyperkalemic Periodic Has associated chemicals Has associated genes
3. DiseasesCongenital, Hereditary, and Neonatal Diseases and Abnormalities Has associated chemicals Has associated genes Has associated exposure references Genetic Diseases, Inborn Has associated chemicals Has associated genes Has associated exposure references Metabolism, Inborn Errors Has associated chemicals Has associated genes Has associated exposure references Metal Metabolism, Inborn Errors Has associated chemicals Has associated genes Paralyses, Familial Periodic Has associated chemicals Has associated genes Paralysis, Hyperkalemic Periodic Has associated chemicals Has associated genes
4. DiseasesNutritional and Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Metabolism, Inborn Errors Has associated chemicals Has associated genes Has associated exposure references Metal Metabolism, Inborn Errors Has associated chemicals Has associated genes Paralyses, Familial Periodic Has associated chemicals Has associated genes Paralysis, Hyperkalemic Periodic Has associated chemicals Has associated genes

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