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Disease Myasthenia Gravis, Neonatal

Name Myasthenia Gravis, Neonatal
Synonyms Antenatal Myasthenia Gravis | Myasthenia Gravis, Antenatal | Myasthenia Gravis, Neonatal, Persistent | Myasthenia Gravis, Neonatal, Transient | Myasthenia Gravis, Persistent, Neonatal | Myasthenia Gravis, Transient, Neonatal | Neonatal Myasthenia Gravis | Neonatal Myasthenia Gravis, Persistent | Neonatal Myasthenia Gravis, Transient | Persistent Neonatal Myasthenia Gravis | Transient Neonatal Myasthenia Gravis
Definition A disorder of neuromuscular transmission that occurs in a minority of newborns born to women with myasthenia gravis. Clinical features are usually present at birth or develop in the first 3 days of life and consist of hypotonia and impaired respiratory, suck, and swallowing abilities. This condition is associated with the passive transfer of acetylcholine receptor antibodies through the placenta. In the majority of infants the myasthenic weakness resolves (i.e., transient neonatal myasthenia gravis) although this disorder may rarely continue beyond the neonatal period (i.e., persistent neonatal myasthenia gravis). (From Menkes, Textbook of Child Neurology, 5th ed, p823; Neurology 1997 Jan;48(1):50-4)
Categories Immune system disease | Nervous system disease
MeSH® ID D020941
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1. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Autoimmune Diseases of the Nervous System Has associated chemicals Has associated genes Has associated exposure references Myasthenia Gravis Has associated chemicals Has associated genes Myasthenia Gravis, Neonatal
2. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Neuromuscular Diseases Has associated chemicals Has associated genes Has associated exposure references Neuromuscular Junction Diseases Has associated chemicals Has associated genes Myasthenia Gravis Has associated chemicals Has associated genes Myasthenia Gravis, Neonatal
3. DiseasesImmune System Diseases Has associated chemicals Has associated genes Has associated exposure references Autoimmune Diseases Has associated chemicals Has associated genes Has associated exposure references Autoimmune Diseases of the Nervous System Has associated chemicals Has associated genes Has associated exposure references Myasthenia Gravis Has associated chemicals Has associated genes Myasthenia Gravis, Neonatal

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