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Disease Male Urogenital Diseases

These are exposure studies associated with the disease and all of its children.

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1–50 of 82 results.
  Reference Associated Study Title Author's Summary Study Factors Stressor Receptors Country Medium Exposure Marker Measurements Outcome
1. Ji G, et al. (2010). Nanjing Medical University Infertile Study These findings provided the first evidence that polymorphisms of XRCC1 may modify sperm Polycyclic Aromatic Hydrocarbons-DNA adduct levels and may be useful biomarkers to identify individuals susceptible to DNA damage resulting from PAHs exposure. genetics 1-hydroxypyrene Subjects with disease:Infertility, Male China urine 1-hydroxypyrene Details Infertility, Male
2. Meeker JD, et al. (2004). In the present study we found associations between urinary metabolites of contemporary-use insecticides and decreased sperm concentration and motility in humans. 1-naphthol | 3,5,6-trichloro-2-pyridinol | Insecticides Subjects with disease:Infertility, Male United States semen | urine 1-naphthol | 3,5,6-trichloro-2-pyridinol Details Infertility, Male | spermatogenesis | sperm motility
3. Main KM, et al. (2007). Two different proxies were used for prenatal polybrominated diphenyl ethers exposure, and levels in breast milk, but not in placenta, showed an association with congenital cryptorchidism. 2,2',3,4,4',5',6-heptabromodiphenyl ether | 2,2',4,4',5,5'-hexabrominated diphenyl ether | 2,2',4,4'-tetrabromodiphenyl ether | Halogenated Diphenyl Ethers | hexabromodiphenyl ether 154 | pentabromodiphenyl ether | tribromodiphenyl ether 28 Infants or newborns | Mothers Denmark|Finland milk, human | placenta 2,2',3,4,4',5',6-heptabromodiphenyl ether | 2,2',4,4',5,5'-hexabrominated diphenyl ether | 2,2',4,4'-tetrabromodiphenyl ether | Halogenated Diphenyl Ethers | hexabromodiphenyl ether 154 | pentabromodiphenyl ether | tribromodiphenyl ether 28 Details Cryptorchidism
4. Koutros S, et al. (2011). Agricultural Health Study (AHS) We evaluated pesticide-single nucleotide polymorphism (SNP) interactions between 45 pesticides and 1913 xenobiotic metabolic enzyme SNPs with respect to prostrate cancer among 776 cases and 1444 controls in the Agricultural Health Study. genetics 2,4,5-Trichlorophenoxyacetic Acid | Carbaryl | Diazinon | Dieldrin | Fonofos | Lindane | methyl bromide | Petroleum | Phorate | terbufos Subjects with gene influence:GCLC | Workers United States Details Agricultural Workers' Diseases | Prostatic Neoplasms
5. Godduhn A, et al. (2013). Northway Health Study (NHS) The NHS found complex patterns of association between reported resource uses and cancer and thyroid-, reproductive-, metabolic-, and cardiac problems. 2,4,5-Trichlorophenoxyacetic Acid | Chlorine | Pesticides | Petroleum | Vehicle Emissions Study subjects United States Details Cardiovascular Diseases | Neoplasms | Thyroid Diseases | Urologic Diseases
6. Swan SH, et al. (2003). Study for Future Families (SFF) This is the first population-based study to demonstrate links between specific biomarkers of environmental exposures and biomarkers of male reproduction in humans. 2,4-Dichlorophenoxyacetic Acid | acetochlor | alachlor | Atrazine | DEET | Diazinon | Malathion | metolachlor Controls for disease:Infertility, Male | Subjects with disease:Infertility, Male United States semen 2,4-Dichlorophenoxyacetic Acid | acetochlor | alachlor | Atrazine | DEET | Diazinon | Malathion | metolachlor Details Infertility, Male
7. Zafar MB, et al. (2001). Agent Orange may have a role in the causation of some types of cancer but we identified no significant relationship of prostate cancer with Agent Orange exposure in patients referred for prostate biopsy. Agent Orange | Defoliants, Chemical Veterans United States Details Prostatic Neoplasms
8. Chamie K, et al. (2008). Individuals who were exposed to Agent Orange had an increased incidence of prostate cancer, developed the disease at a younger age, and had a more aggressive variant than their unexposed counterparts. Agent Orange | Defoliants, Chemical Veterans United States Details Prostatic Neoplasms
9. Lebov JF, et al. (2016). Agricultural Health Study (AHS) In this study of male pesticide applicators, risk of end-stage renal disease increased with increasing cumulative exposure to several pesticides, including the herbicides alachlor, metolachlor, paraquat and pendimethalin, and the insecticide permethrin. alachlor | Aldicarb | Atrazine | Chlordan | Coumaphos | imazethapyr | metalaxyl | metolachlor | Paraquat | Parathion | pendimethalin | Permethrin | Petroleum | Phorate Workers United States Details Kidney Failure, Chronic
10. Christensen CH, et al. (2016). Agricultural Health Study (AHS) In this case-control study nested within the Agricultural Health Study cohort, we evaluated evidence of statistical interaction between pesticide exposure and single nucleotide polymorphisms in genes involved in steroid hormone signaling, metabolism, or regulation with the risk of prostate cancer. genetics alachlor | butylate | Carbaryl | Dicamba | Fonofos | Malathion | terbufos Subjects with gene influence:ESR1 | Subjects with gene influence:HSD17B4 | Subjects with gene influence:SHBG | Subjects with gene influence:SRD5A1 | Subjects with gene influence:SULT2A1 | Workers United States Details Prostatic Neoplasms
11. Koutros S, et al. (2013). Agricultural Health Study (AHS) In this analysis, we observed significant increases in the risk of aggressive prostate cancer associated with 4 insecticides: fonofos (organophosphate), malathion (organophosphate), terbufos (organophosphate), and aldrin (organochlorine). Aldrin | Fonofos | Malathion | terbufos Workers United States Details Agricultural Workers' Diseases | Prostatic Neoplasms
12. Koutros S, et al. (2013). Agricultural Health Study (AHS) We observed four quantitative interactions between genome-wide association studies loci and select pesticide use and risk of prostate cancer. genetics Aldrin | Malathion Subjects with gene influence:EHBP1 | Subjects with gene influence:TET2 | Workers United States Details Prostatic Neoplasms
13. Fénichel P, et al. (2012). The presence of unconjugated bisphenol A in all cord blood samples suggests placental transfer and fetal exposure. Androstenedione | bisphenol A | Estradiol | Estriol | Estrone | Testosterone Controls for disease:Cryptorchidism | Subjects with disease:Cryptorchidism | Infants or newborns France blood, cord Androstenedione | bisphenol A | Estradiol | Estriol | Estrone | Testosterone Details
14. Jelaković B, et al. (2012). In summary, we provide molecular epidemiologic evidence that supports strongly the hypothesis that, in genetically susceptible individuals, dietary exposure to aristolochic acid is causally related to endemic (Balkan) nephropathy and to the carcinomas of the upper urinary tract associated with this disease. diet aristolochic acid I Subjects with disease:Balkan Nephropathy | Subjects with disease:Urologic Neoplasms Bosnia and Herzegovina|Croatia|
Serbia
TP53 Details Balkan Nephropathy | Urologic Neoplasms
15. Wang YH, et al. (2013). Ever smokers with high arsenic exposure had significantly increased risks for bladder cancer and upper urinary tract urothelial carcinoma, and our findings suggest that arsenic exposure, cigarette smoking, and risk genotypes of VEGFA contribute to a higher risk of upper urinary tract urothelial carcinoma than of bladder cancer. genetics | tobacco Arsenic Subjects with disease:Urologic Neoplasms | Subjects with gene influence:VEGFA Taiwan, Province of China Details Urinary Bladder Neoplasms
16. Bates MN, et al. (2004). This study suggests lower bladder cancer risks for arsenic than predicted from other studies but adds to evidence that the latency for arsenic-induced bladder cancers may be longer than previously thought. tobacco Arsenic Controls for disease:Urinary Bladder Neoplasms | Subjects with disease:Urinary Bladder Neoplasms Argentina water Arsenic Details Urinary Bladder Neoplasms
17. Michaud DS, et al. (2004). Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC) In summary, we observed no association between low-level arsenic exposure and bladder cancer risk in a Finnish population followed up for as long as 14 years. Arsenic Controls for disease:Urinary Bladder Neoplasms | Subjects with disease:Urinary Bladder Neoplasms Finland nail Arsenic Details Urinary Bladder Neoplasms
18. Yuan Y, et al. (2007). We conclude that the major impact of arsenic in drinking water on circulatory disease involves acute myocardial infarction and that, in the initial years, it is the main cause of death from arsenic in drinking water, superseded in later years by excess mortality from lung and bladder cancer. Arsenic Study subjects Chile water Arsenic Details Lung Neoplasms | Myocardial Infarction | Urinary Bladder Neoplasms
19. Hsieh FI, et al. (2008). Results suggested that chronic arsenic exposure has a negative impact on erectile function. age Arsenic Study subjects Taiwan, Province of China Details Erectile Dysfunction | regulation of hormone metabolic process
20. Beebe-Dimmer JL, et al. (2012). Genetic variations in AS3MT are associated with bladder cancer among those exposed to relatively low concentrations of inorganic arsenic from drinking water. diet | genetics Arsenic Subjects with gene influence:AS3MT | Controls for disease:Urinary Bladder Neoplasms | Subjects with disease:Urinary Bladder Neoplasms United States water, drinking Arsenic Details Urinary Bladder Neoplasms
21. Li P, et al. (2012). Third National Death Cause Survey (NDCS) Occupational agents represent an important cause of cancer, but indoor radon plays a relatively limited role in cancer causes in China. Arsenic | Asbestos | Benzene | benzidine | Chromates | Coke | Radon | Silicon Dioxide Study subjects China Details Leukemia | Lung Neoplasms | Mesothelioma | Urinary Bladder Neoplasms
22. Karmaus W, et al. (2008). The findings of this 2-year follow-up study indicate that metals and metalloids do not play a role in the etiology of Balkan Endemic Nephropathy. Against the assumption in the literature, selenium was not protective but a risk factor. Arsenic | Cadmium | Creatinine | Lead | Selenium Study subjects Bulgaria blood | serum | urine Arsenic | Cadmium | Creatinine | Lead | Selenium Details Balkan Nephropathy | creatinine homeostasis | gene expression
23. Nachman KE, et al. (2016). National Health and Nutrition Examination Survey (NHANES) Our study provides evidence that use of nitarsone in turkey production can contribute to inorganic arsenic and methylated arsenic species exposure among turkey consumers. Arsenic | nitarsone Children | Study subjects United States turkey Arsenic | Cacodylic Acid | monomethylarsonic acid | nitarsone Details Lung Neoplasms | Urinary Bladder Neoplasms
24. Loeb S, et al. (2015). Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Trial This study suggests that selenium supplements may reduce genetic risk of advanced prostate cancer, whereas aspirin, ibuprofen, and vegetables may reduce genetic risk of nonadvanced prostate cancer. genetics Aspirin | Ibuprofen | Selenium Controls for disease:Prostatic Neoplasms | Subjects with disease:Prostatic Neoplasms United States Details Prostatic Neoplasms
25. Freeman LE, et al. (2011). Agricultural Health Study (AHS) In this report, we extend a previous Agricultural Health Study analysis of cancer risk associated with self-reported atrazine use with six additional years of follow-up and more than twice as many cancer cases. Atrazine Workers United States Details Breast Neoplasms | Leukemia | Lymphoma, Non-Hodgkin | Neoplasms | Ovarian Neoplasms | Prostatic Neoplasms | Thyroid Neoplasms
26. Andreotti G, et al. (2012). Agricultural Health Study (AHS) In this nested case-control study, we evaluated the interaction between pesticide use and single nucleotide polymorphisms in genes related to lipid metabolism. genetics Atrazine | Carbofuran | EPTC | Fonofos | glyphosate | Petroleum | terbufos Subjects with gene influence:A4GALT | Subjects with gene influence:ABCG8 | Subjects with gene influence:ACSL5 | Subjects with gene influence:ADIPOR1 | Subjects with gene influence:ALOX15 | Subjects with gene influence:ALOX5AP | Subjects with gene influence:ALOX5 | Subjects with gene influence:ALOXE3 | Subjects with gene influence:LDLR | Subjects with gene influence:LRP1 | Subjects with gene influence:SEC14L2 | Workers United States Details Prostatic Neoplasms
27. Karami S, et al. (2013). Agricultural Health Study (AHS) In this study, genetic variations in vitamin D pathway genes, particularly GC rs7041, a single nucleotide polymorphism previously linked to lower circulating vitamin D levels, modified pesticide associations with prostate cancer risk. genetics Atrazine | metribuzin | Parathion | Petroleum | terbufos Subjects with gene influence:GC | Subjects with gene influence:RXRA | Subjects with gene influence:RXRB | Subjects with gene influence:VDR | Workers United States Details Agricultural Workers' Diseases | Prostatic Neoplasms
28. Pierik FH, et al. (2007). Collaborative Perinatal Project (CPP) These results provide little support for an association of cryptorchidism with exposure to low levels of heptachlor epoxide or hexachlorobenzene. For beta-hexachlorocyclohexane the findings were somewhat suggestive of an association but were inconclusive. beta-hexachlorocyclohexane | Dichlorodiphenyl Dichloroethylene | Heptachlor Epoxide | Hexachlorobenzene Pregnant females United States serum beta-hexachlorocyclohexane | Dichlorodiphenyl Dichloroethylene | Heptachlor Epoxide | Hexachlorobenzene Details Cryptorchidism
29. Meeker JD, et al. (2010). We found that urinary bisphenol A concentrations measured in spot urine samples collected on the same day as a semen sample were associated with suggestive declines in semen quality parameters and with increased sperm DNA damage (measured as Tail%). bisphenol A Subjects with disease:Infertility, Male | Study subjects United States urine bisphenol A Details Infertility, Male | spermatogenesis | sperm motility
30. Li DK, et al. (2010). Our results reveal a correlation between a biological measure of urine bisphenol A level and declining male sexual function. bisphenol A Workers China urine bisphenol A Details Erectile Dysfunction | penile erection
31. Lynch SM, et al. (2009). Agricultural Health Study (AHS) We examined butylate use and cancer risk more broadly in the Agricultural Health Study, a cohort of licensed pesticide applicators in Iowa and North Carolina. butylate Workers United States Details Agricultural Workers' Diseases | Hematologic Neoplasms | Lymphoma, Non-Hodgkin | Prostatic Neoplasms
32. Alavanja MC, et al. (2003). Agricultural Health Study (AHS) Use of chlorinated pesticides among applicators over 50 years of age and methyl bromide use were significantly associated with prostate cancer risk. age butylate | Chlorpyrifos | Coumaphos | Fonofos | methyl bromide | Permethrin | Phorate Workers United States Details Agricultural Workers' Diseases | Prostatic Neoplasms
33. Satarug S, et al. (2017). National Health and Nutrition Examination Survey (NHANES) Using a Cadmium-toxicokinetic simulation model, we have found that current tolerable dietary intake guidelines do not contain a safety margin, given that the modeled dietary intake levels exceed the levels associated with kidney damage and many other adverse health outcomes seen in cohorts and cross-sectional studies. Cadmium Controls for disease:Breast Neoplasms | Subjects with disease:Breast Neoplasms | Study subjects Japan|United States urine Details Breast Neoplasms | Kidney Diseases | Vascular Diseases
34. Nishijo M, et al. (2006). Renal tubular dysfunction induced by Cd affected the causes of death, and mortality for heart failure, cerebral infarction, and nephritis and nephrosis was increased among inhabitants living in a Cd polluted area in Japan. Cadmium Study subjects Japan urine B2M Details Death | Kidney Diseases
35. Arora M, et al. (2009). National Health and Nutrition Examination Survey (NHANES) In the present study, we found that environmental Cadmium (Cd) exposure, as measured by creatinine-corrected urine Cd concentration, was associated with increased odds of prevalent periodontal disease in U.S. adults. tobacco Cadmium Controls for disease:Diabetes Mellitus | Subjects with disease:Diabetes Mellitus | Controls for disease:Periodontal Diseases | Subjects with disease:Periodontal Diseases | Controls for disease:Renal Insufficiency | Subjects with disease:Renal Insufficiency | Study subjects United States urine Cadmium Details Periodontal Diseases
36. Ferraro PM, et al. (2010). National Health and Nutrition Examination Survey (NHANES) Moderately high levels of urinary and blood Cadmium are associated with a higher proportion of chronic kidney disease and albuminuria in the United States population. Cadmium Controls for disease:Albuminuria | Subjects with disease:Albuminuria | Controls for disease:Renal Insufficiency, Chronic | Subjects with disease:Renal Insufficiency, Chronic | Study subjects United States blood | urine Cadmium Details Albuminuria | Renal Insufficiency, Chronic
37. Pennemans V, et al. (2011). Urinary kidney injury molecule 1 levels are positively correlated with urinary cadmium concentration in an elderly population after long-term, low-dose exposure to cadmium, while other classical markers do not show an association; therefore, urinary kidney injury molecule 1 might be considered as a biomarker for early-stage metal-induced kidney injury by cadmium. Cadmium Study subjects Belgium urine Cadmium | HAVCR1 Details Kidney Diseases
38. Liang Y, et al. (2012). Results suggest that a Cadmium-mediated increase in urinary albumin excretion is reversible upon substantial reduction of exposure. Cadmium Study subjects China blood | urine Cadmium Details Albuminuria | Kidney Diseases | renal system process
39. Navas-Acien A, et al. (2009). National Health and Nutrition Examination Survey (NHANES) In this large, representative sample of US adults, increased blood cadmium and lead levels were strong, independent risk factors for the prevalence of albuminuria, reduced estimated glomerular filtration rate, and both outcomes together. Cadmium | Lead Controls for disease:Albuminuria | Subjects with disease:Albuminuria | Study subjects United States blood Cadmium | Lead Details Albuminuria | Kidney Diseases | glomerular filtration
40. Buser MC, et al. (2016). National Health and Nutrition Examination Survey (NHANES) The inverse association between estimated glomerular filtration rate (eGFR) and blood Cadmium (B-Cd), in conjunction with positive associations between eGFR and albumin with urinary Cadmium (U-Cd), suggest that U-Cd measurement at low levels of exposure may result from changes in renal excretion of Cd due to kidney function and protein excretion. Cadmium | Lead Study subjects United States blood | urine Details Albuminuria | glomerular filtration
41. Barry KH, et al. (2012). Agricultural Health Study (AHS) Although we did not observe highly significant nucleotide excision repair (NER) single-nucleotide polymorphism (SNP) main effects, our interaction findings between SNPs tagging ERCC1 and CDK7 and fonofos and carbofuran, respectively, suggest the importance of the NER pathway in prostate cancer risk in the presence of certain pesticide exposures. genetics Carbofuran | Dichlorvos | Fonofos | Parathion | Petroleum Subjects with gene influence:CDK7 | Subjects with gene influence:DDB2 | Subjects with gene influence:ERCC1 | Subjects with gene influence:ERCC4 | Workers | Subjects with gene influence:XAB2 United States Details Agricultural Workers' Diseases | Prostatic Neoplasms
42. Multigner L, et al. (2016). We review the findings of various, previous epidemiological studies conducted in the French West Indies to assess the impact of environmental exposure to chlordecone on the health of the population. Chlordecone Infants or newborns | Mothers | Pregnant females | Subjects with disease:Prostatic Neoplasms | Workers Guadeloupe blood | blood, cord | colostrum | milk, human | plasma | subcutaneous fat, abdominal Chlordecone Details Infertility, Male | Prostatic Neoplasms
43. Christensen CH, et al. (2010). Agricultural Health Study (AHS) We observed an increased risk of prostate cancer in association with coumaphos exposure among men with a family history of prostate cancer but not among men without a family history in both early (1993-1999) and later periods in cohort follow-up (2000-2005), although the interaction rate ratio in the early period is stronger than in the later period. genetics Coumaphos Workers United States Details Prostatic Neoplasms
44. Koutros S, et al. (2010). Agricultural Health Study (AHS) In this study we evaluated the interaction between pesticide use, genetic variation on chromosome 8q24, and risk of prostate cancer in 2,220 Agricultural Health Study subjects. genetics Coumaphos | Fonofos | Permethrin | Phorate | terbufos Workers United States Details Prostatic Neoplasms
45. Lynch SM, et al. (2006). Agricultural Health Study (AHS) We did not find any clear, consistent associations between cyanazine exposure and any cancer analyzed. cyanazine Workers United States Details Colonic Neoplasms | Hematologic Neoplasms | Lung Neoplasms | Lymphoma, Non-Hodgkin | Neoplasms | Prostatic Neoplasms
46. Jones RR, et al. (2015). Agricultural Health Study (AHS) Our updated evaluation of diazinon provides additional evidence of an association with lung cancer risk; newly identified links to kidney cancer and associations with aggressive prostate cancer require further evaluation. Diazinon Workers United States Details Agricultural Workers' Diseases | Kidney Neoplasms | Lung Neoplasms | Prostatic Neoplasms
47. Mínguez-Alarcón L, et al. (2016). Russian Children's Study Our prospective cohort study showed that higher peripubertal serum 2,3,7,8-tetrachlorodibenzo-p-dioxin and polychlorinated dibenzo-p-dioxins toxic equivalents were associated with lower sperm concentration, total sperm count, and total motile sperm count measured 10 years later in healthy young men. Dibenzofurans, Polychlorinated | Dioxins | Furans | Polychlorinated Biphenyls | Polychlorinated Dibenzodioxins | Tetrachlorodibenzodioxin Children | Study subjects Russian Federation serum Dibenzofurans, Polychlorinated | Polychlorinated Biphenyls | Polychlorinated Dibenzodioxins | Tetrachlorodibenzodioxin Details Infertility, Male | spermatogenesis | sperm motility
48. Perry MJ, et al. (2011). We investigated whether there was an association between urinary organophosphorous insecticide metabolites and sperm concentration and motility in newly married men from a rural area of eastern People's Republic of China. diethyl phosphate | dimethyl phosphate | O,O-diethyl dithiophosphate | O,O-dimethyl phosphorodithioate | O,O-dimethyl phosphorothionate | thiophosphoric acid Controls for disease:Infertility, Male | Subjects with disease:Infertility, Male China urine diethyl phosphate | dimethyl phosphate | O,O-diethyl dithiophosphate | O,O-dimethyl phosphorodithioate | O,O-dimethyl phosphorothionate | thiophosphoric acid Details spermatid development | sperm motility
49. Hodgson S, et al. (2004). There is a significant excess of kidney disease and kidney disease mortality in people living near to several polluting sources in Runcorn. Environmental Pollutants Study subjects United Kingdom Details Death | Nephritis | Nephrosis | Nephrotic Syndrome
50. Barry KH, et al. (2011). Agricultural Health Study (AHS) In this nested case-control study of white male pesticide applicators within the Agricultural Health Study cohort, we observed notable interactions between several pesticides and base excision repair gene variants with respect to prostate cancer. genetics Fonofos Subjects with gene influence:NEIL3 | Workers United States Details Agricultural Workers' Diseases | Prostatic Neoplasms
1–50 of 82 results.