Skip navigation

Disease Frontotemporal Lobar Degeneration

Name Frontotemporal Lobar Degeneration
Synonyms Degeneration, Frontotemporal Lobar | Degenerations, Frontotemporal Lobar | Frontotemporal Lobar Degenerations | FTLD | FTLDs | Lobar Degeneration, Frontotemporal | Lobar Degenerations, Frontotemporal
Definition Heterogeneous group of neurodegenerative disorders characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Multiple subtypes or forms are recognized based on presence or absence of TAU PROTEIN inclusions. FTLD includes three clinical syndromes: FRONTOTEMPORAL DEMENTIA, semantic dementia, and PRIMARY PROGRESSIVE NONFLUENT APHASIA.
Categories Mental disorder | Metabolic disease | Nervous system disease
MeSH® ID D057174

Top ↑ Ancestors

1. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Central Nervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Brain Diseases Has associated chemicals Has associated genes Has associated exposure references Dementia Has associated chemicals Has associated genes Has associated exposure references Frontotemporal Lobar Degeneration Has associated chemicals Has associated genes
2. DiseasesNervous System Diseases Has associated chemicals Has associated genes Has associated exposure references Neurodegenerative Diseases Has associated chemicals Has associated genes Has associated exposure references TDP-43 Proteinopathies Has associated chemicals Has associated genes Has associated exposure references Frontotemporal Lobar Degeneration Has associated chemicals Has associated genes
3. DiseasesNutritional and Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Metabolic Diseases Has associated chemicals Has associated genes Has associated exposure references Proteostasis Deficiencies Has associated chemicals Has associated genes Has associated exposure references TDP-43 Proteinopathies Has associated chemicals Has associated genes Has associated exposure references Frontotemporal Lobar Degeneration Has associated chemicals Has associated genes
4. DiseasesMental Disorders Has associated chemicals Has associated genes Has associated exposure references Neurocognitive Disorders Has associated chemicals Has associated genes Has associated exposure references Dementia Has associated chemicals Has associated genes Has associated exposure references Frontotemporal Lobar Degeneration Has associated chemicals Has associated genes

Top ↑ Descendants

Frontotemporal Lobar Degeneration Has associated chemicals Has associated genes
View node Frontotemporal Dementia Has associated chemicals Has associated genes
  FRONTOTEMPORAL LOBAR DEGENERATION WITH TDP43 INCLUSIONS, GRN-RELATED Has associated chemicals Has associated genes
  Pick Complex
  Primary Progressive Nonfluent Aphasia