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GO Term cell death

Name cell death
Related Synonyms accidental cell death | necrosis
Definition Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as 'apoptotic bodies'); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo.
Comment This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term.
Ontology Biological Process
GO ID GO:0008219
External Links

Top ↑ Ancestors

1. ALLis a biological_process Has associated genes Has associated diseases is a single-organism process Has associated genes Has associated diseases is a death Has associated genes Has associated diseases is a cell death Has associated genes Has associated diseases
2. ALLis a biological_process Has associated genes Has associated diseases is a single-organism process Has associated genes Has associated diseases is a single-organism cellular process Has associated genes Has associated diseases is a cell death Has associated genes Has associated diseases
3. ALLis a biological_process Has associated genes Has associated diseases is a cellular process Has associated genes Has associated diseases is a single-organism cellular process Has associated genes Has associated diseases is a cell death Has associated genes Has associated diseases

Top ↑ Descendants

cell death Has associated genes Has associated diseases
View nodeis a cell death in response to oxidative stress Has associated genes Has associated diseases
View nodeis a necrotic cell death Has associated genes Has associated diseases
View nodenegatively regulates negative regulation of cell death Has associated genes Has associated diseases
View nodeis a neuron death Has associated genes Has associated diseases
View nodepositively regulates positive regulation of cell death Has associated genes Has associated diseases
View nodeis a programmed cell death Has associated genes Has associated diseases
View noderegulates regulation of cell death Has associated genes Has associated diseases