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Reference In Utero and Childhood Polybrominated Diphenyl Ether Exposures and Body Mass at Age 7 Years: The CHAMACOS Study.

Authors Erkin-Cakmak A, Harley KG, Chevrier J, Bradman A, Kogut K, Huen K, Eskenazi B.
Institution Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California at Berkeley, California, USA.
Citation Environ Health Perspect. 2015 Feb 27.
DOI ID 10.1289/ehp.1408417
PubMed® ID 25738596
Review Status Is curated Curated.
Abstract BACKGROUND AND OBJECTIVES: Polybrominated diphenyl ethers (PBDEs) are lipophilic flame retardants that bioaccumulate in humans. Child serum PBDE concentrations in California are among the highest worldwide. PBDEs may be associated with obesity by disrupting endocrine systems. In this study, we examined whether pre- and post-natal exposure to the components of penta-BDE mixture was associated with childhood obesity in a population of Latino children participating in a longitudinal birth cohort study in the Salinas Valley, California.

METHODS: We measured PBDEs in serum collected from 224 mothers during pregnancy and their children at 7 years of age, and examined associations with body mass index at age 7.

RESULTS: Maternal PBDE serum levels during pregnancy were associated with higher body mass index (BMI) z-scores in boys (BMI z-score ╬▓adjusted = 0.26; 95% CI: -0.19, 0.72) but lower scores in girls (BMI z-score ╬▓adjusted = -0.41; 95% CI: -0.87, -0.05) at 7 years of age (pinteraction= 0.04). In addition, child''s serum BDE-153 concentration (log10), but not other penta-BDE congeners, demonstrated inverse associations with body mass index at age 7 (BMI z-score ╬▓adjusted= -1.15, 95% CI -1.53, -0.77) but there was no interaction by sex.

CONCLUSIONS: We estimated sex-specific associations with maternal PBDE levels during pregnancy and body mass index at age 7 with positive associations in boys and negative associations in girls. Children''s serum BDE-153 concentrations were inversely associated with body mass index at age 7 with no difference by sex. Future studies should examine the longitudinal trends in obesity with PBDE exposure and changes in hormonal environment as children transition through puberty, as well as evaluate the potential for reverse causality.